Significant Ownership of RA CAPITAL MANAGEMENT, L.P.

Signature - Title
/s/ Peter Kolchinsky - By Peter Kolchinsky, Authorized Signatory
Location
Boston, MA
Summary
This page shows a list of all the recent SCHEDULE 13D/G filings made by RA CAPITAL MANAGEMENT, L.P..

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Significant Ownership of RA CAPITAL MANAGEMENT, L.P.

Sym Company Class Ownership Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
CLYM CLIMB BIO, INC. Common Stock, par value $0.0001 per share 33% $36,086,101 17,953,284 RA Capital Management, L.P. 11 Dec 2025
VOR VOR BIOPHARMA INC. Common Stock, par value $0.0001 per share 32% $7,947,970 +$6,000 39,739,850 +0.08% RA Capital Management, L.P. 25 Jun 2025
PEPG PEPGEN INC. Common stock, par value $0.0001 per share 29% $26,531,674 20,099,753 RA Capital Management, L.P. 26 Sep 2025
ABOS Acumen Pharmaceuticals, Inc. Common Stock, $0.0001 par value per share 25% $16,517,669 15,016,063 RA Capital Management, L.P. 27 Mar 2025
SPYGLASS PHARMA, INC. Common Stock, $0.00001 par value per share 24% 8,022,639 RA Capital Management, L.P. 09 Feb 2026
SION SIONNA THERAPEUTICS, INC. Common Stock, $0.001 par value per share 23% $296,218,114 -$10,988,206 10,071,712 -3.6% RA Capital Management, L.P. 05 Nov 2025
TYRA TYRA BIOSCIENCES, INC. Common Stock, $0.0001 par value per share 21% $380,263,825 +$11,370,397 12,266,575 +3.1% RA Capital Management, L.P. 04 Mar 2026
JANX JANUX THERAPEUTICS, INC. Common Stock, par value $0.001 per share 20% $383,922,060 11,971,377 RA Capital Management, L.P. 06 Mar 2025
VOR VOR BIOPHARMA INC. Common Stock, par value $0.0001 per share 14% $43,075,707 +$24,407,302 5,411,521 +131% RA Capital Management, L.P. 18 Dec 2025
HOWL WEREWOLF THERAPEUTICS, INC. Common Stock, $0.0001 par value per share 14% $13,162,175 -$129,035 6,681,307 -0.97% RA Capital Management, L.P. 04 Nov 2025
LENZ LENZ THERAPEUTICS, INC. Common Stock, $0.00001 par value per share 14% $198,668,637 +$209,610 4,265,106 +0.11% RA Capital Management, L.P. 05 Nov 2025
WVE WAVE LIFE SCIENCES LTD. Common Stock, $0.00001 par value per share 13% $169,771,577 25,453,010 0% RA Capital Management, L.P. 11 Dec 2025
GHRS GH Research PLC Ordinary Shares, Nominal value of $0.025 per share 12% $123,210,987 +$11,749,386 7,676,697 +11% RA Capital Management, L.P. 30 Jun 2025
BCAX BICARA THERAPEUTICS INC. Common Stock, par value $0.0001 per share 12% $123,100,386 7,279,739 RA Capital Management, L.P. 26 Feb 2026
SPRY ARS PHARMACEUTICALS, INC. Common Stock, par value $0.0001 per share 11% $111,050,917 10,940,977 RA Capital Management, L.P. 29 Sep 2025
RYTM RHYTHM PHARMACEUTICALS, INC. Common Stock, $0.001 par value per share 9.9% $662,816,935 +$109,906,623 6,666,837 +20% RA Capital Management, L.P. 31 Dec 2025
PCVX VAXCYTE, INC. Common Stock, $0.001 par value per share 9.9% $426,531,754 12,964,491 RA Capital Management, L.P. 31 Mar 2025
NAMS NEWAMSTERDAM PHARMA COMPANY N.V. Ordinary Shares, nominal value EUR0.12 per share 9.9% $205,220,969 +$3,481,297 11,063,125 +1.7% RA Capital Management, L.P. 31 Mar 2025
EWTX Edgewise Therapeutics, Inc. Common Stock, par value $0.0001 per share 9.9% $169,149,248 10,428,437 RA Capital Management, L.P. 30 Sep 2025
RZLT Rezolute, Inc. Common Stock, par value $0.001 per share 9.9% $146,288,898 15,302,186 RA Capital Healthcare Fund, L.P. 11 Dec 2025
MLYS MINERALYS THERAPEUTICS, INC. Common Stock, par value $0.0001 per share 9.9% $104,939,988 +$20,308,933 7,796,433 +24% RA Capital Management, L.P. 04 Sep 2025
TSHA TAYSHA GENE THERAPIES, INC. Common Stock, $0.00001 par value per share 9.9% $90,456,313 +$7,574,932 27,662,481 +9.1% RA Capital Management, L.P. 30 Sep 2025
GERN GERON CORPORATION Common Stock, $0.001 par value per share 9.9% $88,303,586 63,988,106 RA Capital Management, L.P. 31 Mar 2025
IVVD Invivyd, Inc. Common Stock, $0.0001 par value per share 9.9% $72,720,164 +$18,947,678 28,857,208 +35% RA Capital Management, L.P. 31 Dec 2025
FULC FULCRUM THERAPEUTICS, INC. Common Stock, $0.001 par value per share 9.9% $67,231,227 +$6,025,691 6,649,973 +9.8% RA Capital Management, L.P. 31 Dec 2025
SLDB SOLID BIOSCIENCES INC. Common Stock, $0.001 par value per share 9.9% $66,971,007 +$11,548,263 9,663,926 +21% RA Capital Management, L.P. 06 Mar 2026
FDMT 4D MOLECULAR THERAPEUTICS, INC. Common Stock, $0.0001 par value per share 9.9% $44,910,877 +$9,031,022 5,713,852 +25% RA Capital Management, L.P. 31 Dec 2025
MNPR Monopar Therapeutics Inc. Common Stock, par value $0.001 per share 9.9% $43,402,756 -$4,890,637 667,632 -10% RA Capital Management, L.P. 31 Dec 2025
AVTX Avalo Therapeutics, Inc. Common Stock, $0.001 par value per share 9.9% $32,867,152 +$9,371,621 1,939,065 +40% RA Capital Management, L.P. 31 Dec 2025
PALI PALISADE BIO, INC. Common Stock, par value $0.01 per share 9.9% $30,233,912 +$11,157,251 15,746,829 +58% RA Capital Management, L.P. 31 Dec 2025
SABS SAB Biotherapeutics, Inc. Common Stock, $0.0001 par value per share 9.9% $21,285,667 +$3,151,487 5,166,424 +17% RA Capital Management, L.P. 09 Mar 2026
CCCC C4 Therapeutics, Inc. Common Stock, $0.0001 par value per share 9.9% $20,959,588 +$20,959,588 9,441,256 RA Capital Management, L.P. 17 Oct 2025
OVID OVID THERAPEUTICS INC. Common Stock par value $0.001 per share 9.9% $19,889,602 13,259,735 RA Capital Management, L.P. 11 Dec 2025
IPSC Century Therapeutics, Inc. Common Stock, par value $0.0001 per share 9.9% $16,997,172 17,944,649 RA Capital Management, L.P. 09 Jan 2026
ALXO ALX Oncology Holdings Inc. Common Stock, par value $0.001 per share 9.9% $16,265,211 13,117,106 RA Capital Management, L.P. 02 Feb 2026
UNCY Unicycive Therapeutics, Inc. Common Stock, $0.001 par value per share 9.9% $14,001,588 +$2,495,038 2,385,279 +22% RA Capital Management, L.P. 31 Dec 2025
CRVO CervoMed Inc. Common Stock, $0.001 par value 9.9% $8,646,810 +$933,559 1,026,937 +12% RA Capital Management, L.P. 30 Jun 2025
UNCY Unicycive Therapeutics, Inc. Common Stock, $0.001 par value per share 9.9% $8,370,042 +$1,112,366 13,285,781 +15% RA Capital Management, L.P. 31 Mar 2025
ACET Adicet Bio, Inc. Common Stock, par value $0.0001 per share 9.9% $7,960,365 960,237 RA Capital Management, L.P. 31 Dec 2025
RANI RANI THERAPEUTICS HOLDINGS, INC. Class A Common Stock, $0.0001 par value per share 9.9% $4,939,262 9,882,477 RA Capital Management, L.P. 23 Oct 2025
SLDB SOLID BIOSCIENCES INC. Common Stock, $0.001 par value per share 9.9% $3,595,419 7,989,820 RA Capital Management, L.P. 19 Feb 2025
EVMN EVOMMUNE, INC. Common Stock, $0.0001 par value per share 9.7% $70,347,063 +$722,023 3,494,638 +1% RA Capital Management, L.P. 12 Feb 2026
ASMB Assembly Biosciences, Inc. Common Stock, par value $0.001 per share 9.5% $28,392,908 1,530,615 RA Capital Management, L.P. 11 Aug 2025
SRZN Surrozen, Inc. Common Stock, $0.0001 par value per share 9.2% $18,001,245 +$89,063 871,731 +0.5% RA Capital Management, L.P. 31 Dec 2025
LBRX LB PHARMACEUTICALS INC Common Stock, $0.0001 par value per share 8.7% $42,029,734 +$10,154,484 2,208,604 +32% RA Capital Management, L.P. 31 Dec 2025
PCSC Perceptive Capital Solutions Corp Class A Ordinary Shares, par value $0.0001 per share 8.4% $7,950,000 750,000 RA Capital Management, L.P. 05 Dec 2025
BCRX BioCryst Pharmaceuticals, Inc. Common Stock, $0.01 par value per share 7.3% $116,143,592 15,302,186 RA Capital Management, L.P. 04 Nov 2025
CTNM Contineum Therapeutics, Inc. Class A Common Stock, $0.001 par value per share 7.2% $24,914,097 +$659,637 2,179,711 +2.7% RA Capital Management, L.P. 31 Dec 2025
ADGM Adagio Medical Holdings, Inc. Common Stock, par value $0.0001 per share 7.2% $1,656,000 1,200,000 0% RA Capital Management, L.P. 30 Jun 2025
JBIO JADE BIOSCIENCES, INC. Common Stock, $0.0001 par value per share 7% $27,758,364 +$16,318,579 3,214,969 +143% RA Capital Management, L.P. 08 Oct 2025
Helix Acquisition Corp. III Class A Ordinary Shares, par value $0.0001 per share 7% 1,250,000 RA Capital Management, L.P. 26 Jan 2026
LXEO Lexeo Therapeutics, Inc. Common Stock, $0.0001 par value per share 6.9% $33,200,000 5,000,000 RA Capital Management, L.P. 20 Oct 2025
DNTH Dianthus Therapeutics, Inc. Common Stock, $0.001 par value per share 6% $94,544,735 -$45,431,000 2,611,733 -32% RA Capital Management, L.P. 31 Dec 2025
RNA Avidity Biosciences, Inc. Common Stock, par value $0.0001 per share 5.9% $376,489,721 8,641,031 RA Capital Management, L.P. 30 Sep 2025
IRON DISC MEDICINE, INC. Common Stock, $0.0001 par value per share 5.9% $177,001,530 2,228,924 RA Capital Management, L.P. 30 Dec 2025
BNTC Benitec Biopharma Inc. Common Stock, par value $0.0001 per share 5.5% $24,327,500 1,850,000 RA Capital Management, L.P. 07 Nov 2025
KURA Kura Oncology, Inc. Common Stock, par value $0.0001 per share 4.9% $26,070,011 4,004,610 RA Capital Management, L.P. 31 Mar 2025
ITOS ITEOS THERAPEUTICS, INC. Common Stock, $0.001 par value per share 4.9% $15,690,824 -$14,909,254 2,134,806 -49% RA Capital Management, L.P. 15 May 2025
TARA Protara Therapeutics, Inc. Common Stock, par value $0.001 per share 4.9% $5,974,448 -$4,423,642 1,971,765 -43% RA Capital Management, L.P. 30 Jun 2025
ZURA ZURA BIO LIMITED Class A Ordinary Shares, par value $0.0001 per share 4.9% $4,633,204 3,217,503 RA Capital Management, L.P. 31 Dec 2024
EYPT EyePoint Pharmaceuticals, Inc. Common Stock, par value $0.001 per share 4.7% $20,809,090 3,181,818 RA Capital Management, L.P. 31 Dec 2024
BIOA BIOAGE LABS, INC. Common Stock, par value $0.00001 per share 3.7% $5,740,380 1,310,589 RA Capital Management, L.P. 31 Dec 2024
EVH Evolent Health, Inc. Class A Common Stock, par value $0.01 per share 3.1% $35,199,618 3,577,197 RA Capital Management, L.P. 31 Dec 2024
DRUG Bright Minds Biosciences Inc. Common Shares 2.9% $6,376,530 206,427 RA Capital Management, L.P. 31 Mar 2025
ACLX Arcellx, Inc. Common Stock, $0.001 par value per share 2.2% $83,974,428 1,267,156 RA Capital Management, L.P. 31 Dec 2025
RXRX Recursion Pharmaceuticals, Inc. Class A Common Stock, par value $0.00001 per share 2% $44,187,549 7,725,096 RA Capital Management, L.P. 31 Dec 2024
VRNA Verona Pharma plc Ordinary Shares, nominal value GBP0.05 per share 0.7% $62,198,806 -$567,585,398 593,670 -90% RA Capital Management, L.P. 30 Jun 2025
ETNB 89BIO, INC. Common Stock, par value $0.001 per share 0% $0 -$294,201,875 0 -100% RA Capital Management, L.P. 30 Oct 2025
RXST RxSight, Inc. Common Stock, par value $0.001 per share 0% $0 0 RA Capital Management, L.P. 30 Sep 2025
ENSC Ensysce Biosciences, Inc. Common Stock, par value $0.0001 per share 0% $0 0 RA Capital Management, L.P. 31 Dec 2024
TRML TOURMALINE BIO, INC. Common stock, par value $0.0001 per share 0% $0 0 RA Capital Management, L.P. 30 Sep 2025
LBPH LONGBOARD PHARMACEUTICALS, INC. Common Stock, par value $0.0001 per share 0% $0 0 RA Capital Management, L.P. 31 Dec 2024
TNYA Tenaya Therapeutics, Inc. Common Stock, $0.0001 par value per share 0% $0 0 RA Capital Management, L.P. 31 Dec 2024
DYN DYNE THERAPEUTICS, INC. Common Stock, $0.0001 par value per share 0% $0 -$122,887,059 0 -100% RA Capital Management, L.P. 30 Sep 2025
ALEC Alector, Inc. Common Stock, par value $0.0001 per share 0% $0 0 RA Capital Management, L.P. 30 Jun 2025
ANTX AN2 THERAPEUTICS, INC. Common Stock, $0.00001 par value per share 0% $0 0 RA Capital Management, L.P. 31 Dec 2024
ANRO Alto Neuroscience, Inc. Common Stock, par value $0.0001 per share 0% $0 0 RA Capital Management, L.P. 31 Dec 2024
MGNX Macrogenics, Inc. Common Stock, par value $0.01 per share 0% $0 0 RA Capital Management, L.P. 31 Dec 2024
GLYC GlycoMimetics, Inc. Common Stock, par value $0.001 per share 0% $0 0 RA Capital Management, L.P. 31 Dec 2024
LRMR Larimar Therapeutics, Inc. Common Stock, par value $0.001 per share 0% $0 0 RA Capital Management, L.P. 31 Dec 2025
ELDN Eledon Pharmaceuticals, Inc. Common Stock, $0.001 par value 0% $0 0 RA Capital Management, L.P. 31 Dec 2025
ATXS Astria Therapeutics, Inc. Common Stock, par value $0.001 per share 0% $0 0 RA Capital Management, L.P. 30 Jun 2025
CDTX CIDARA THERAPEUTICS, INC. Common Stock, $0.0001 par value per share 0% $0 -$745,048,672 0 -100% RA Capital Management, L.P. 07 Jan 2026
BOLD BOUNDLESS BIO, INC. Common Stock, par value $0.0001 per share 0% $0 0 RA Capital Management, L.P. 30 Jun 2025
SERA Sera Prognostics, Inc. Class A Common Stock, $0.0001 par value per share 0% $0 0 RA Capital Management, L.P. 30 Jun 2025
CYBN Cybin Inc. Common Shares, no par value 0% $0 0 RA Capital Management, L.P. 31 Dec 2024
STRO Sutro Biopharma, Inc. Common Stock, $0.001 par value per share 0% $0 -$3,165,887 0 -100% RA Capital Management, L.P. 30 Jun 2025
DAWN DAY ONE BIOPHARMACEUTICALS, INC. Common Stock, par value $0.0001 per share 0% $0 -$38,044,364 0 -100% RA Capital Management, L.P. 30 Jun 2025
CMRX CHIMERIX INC Common Stock, par value $0.001 per share 0% $0 0 RA Capital Management, L.P. 31 Mar 2025
URGN UROGEN PHARMA LTD. Ordinary Shares, par value NIS 0.01 per share 0% $0 -$45,657,299 0 -100% RA Capital Management, L.P. 30 Jun 2025
CTKB CYTEK BIOSCIENCES, INC. Common Stock, par value $0.001 per share 0% $0 0 RA Capital Management, L.P. 31 Dec 2024

Schedules 13D/G Reported by RA CAPITAL MANAGEMENT, L.P.:

Sym Target Class Ownership Change Current Shares Change Value Reporting name Form Report Period Filing Date
* An asterisk sign (*) next to the price indicates that the price is likely invalid.