Latest Period
Q1 2026
Security Snapshot
Taysha Gene Therapies, Inc. - Common Stock, par value $0.00001 per share (TSHA) Institutional Ownership
CUSIP: 877619106
13F Institutional Holders and Ownership History from Q3 2020 to Q1 2026
Institutions Reporting
187
Shares (Excl. Options)
264,720,110
Price
$4.47
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- Security type / class
- Equity / Common Stock, par value $0.00001 per share
- Symbol
- TSHA on Nasdaq
- All holders as of 31 Mar 2026
- Q1 2026
- Total 13F shares
- 264,720,110
- Total 13F value
- $1,182,044,534
- Portfolio coverage rank
- 0%
- Share change
- -3,254,112
- Value change
- -$21,468,733
- Number of holders
- 187
- Shares outstanding
- 285,714,286
- SEC-reported price per share
- $6.85
- Insider filing price
- $6.85
Latest holder snapshot
5 signals
Issuer context
Names, identifiers, and filing context for this profile.
3 identity fields
13F Shares, Excluding Options vs Price
13F Value, Excluding Options
Total Investors
Key facts
- TSHA - Taysha Gene Therapies, Inc. - Common Stock, par value $0.00001 per share is tracked under CUSIP 877619106.
- 187 institutions reported positions in Q1 2026.
- 9 significant owners is listed from Schedule 13D/13G reporting.
Change
- Holder count moved from 195 to 187 between Q4 2025 and Q1 2026.
- SEC-reported value moved from $1,479,387,583 to $1,182,044,534.
Research use
- You can quickly see who holds this security, then open quarter and manager detail pages for full evidence.
- 13F and Schedule 13D/13G sections are kept together so you can cross-check institutional and beneficial ownership context.
Evidence
Source: SEC Form 13F
Open SEC evidence
Latest holder context comes from 187 institutions filings for Q1 2026.
Security key
877619106
Latest holder period
Q1 2026
13F holders
187
13D/G owners
9
CIK / CUSIP context first
Open Q1 2026 holders
TSHA full holder history
Taysha Gene Therapies, Inc. SEC filings
Taysha Gene Therapies, Inc. company facts
Taysha Gene Therapies, Inc. insider transactions
Broader feeds
Recent Quarterly Holder Reports
Open recent reporting periods for CUSIP 877619106:
13D/G owners
Significant owners
Large-stake holder rows connected to Schedule 13D/G evidence.
Rows
9
Security
TSHA
| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | 0% | $90,456,313 | +$7,574,932 | 27,662,481 | +9.1% | RA Capital Management, L.P. | 30 Sep 2025 |
| Manning Paul B | 9.8% | $59,394,578 | 25,601,111 | Paul B Manning | 30 May 2025 | |||
| RTW INVESTMENTS, LP | 7% | -16% | $92,480,205 | -$12,149,679 | 20,689,084 | -12% | RTW Investments, LP | 31 Mar 2026 |
| Vestal Point Capital, LP | 6.3% | +26% | $80,460,000 | +$18,997,500 | 18,000,000 | +31% | Vestal Point Capital, LP | 31 Mar 2026 |
| BlackRock, Inc. | 6.5% | +26% | $98,187,600 | +$25,844,308 | 17,852,291 | +36% | BlackRock, Inc. | 31 Dec 2025 |
| MORGAN STANLEY | 6.7% | -21% | $44,506,820 | -$2,034,437 | 16,858,644 | -4.4% | Morgan Stanley | 30 Jun 2025 |
| FMR LLC | 4.9% | -22% | $74,406,012 | -$11,547,008 | 13,528,366 | -13% | FMR LLC | 31 Dec 2025 |
| GOLDMAN SACHS GROUP INC | 5.1% | $33,274,806 | 12,748,968 | THE GOLDMAN SACHS GROUP, INC. | 26 Jun 2025 | |||
| Octagon Capital Advisors LP | 3.3% | -36% | $29,650,725 | -$4,520,775 | 9,067,500 | -13% | Octagon Capital Advisors LP | 30 Sep 2025 |
As of 31 Mar 2026, 187 institutional investors reported holding 264,720,110 shares of Taysha Gene Therapies, Inc. - Common Stock, par value $0.00001 per share (TSHA). This represents 93% of the company’s total 285,714,286 outstanding shares.
13F concentration
Top 25 institutional shareholders
Largest 13F positions for this security by reported shares and value.
Top holder share
81%
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 8.2% | 23,555,648 | 0% | 1.1% | $105,293,747 |
| GOLDMAN SACHS GROUP INC | 7.8% | 22,369,645 | +63% | 0.01% | $99,992,313 |
| Avoro Capital Advisors LLC | 7.6% | 21,700,000 | 0% | 0.96% | $96,999,000 |
| BlackRock, Inc. | 6.4% | 18,365,608 | -1.5% | 0% | $82,094,268 |
| Vestal Point Capital, LP | 6.3% | 18,000,000 | +31% | 2.2% | $80,460,000 |
| MORGAN STANLEY | 6.3% | 17,965,371 | -0.63% | 0% | $80,305,209 |
| FMR LLC | 5% | 14,321,255 | +5.9% | 0% | $64,016,010 |
| RTW INVESTMENTS, LP | 4.8% | 13,680,248 | -17% | 0.61% | $61,150,709 |
| STATE STREET CORP | 3.9% | 11,209,078 | +3.9% | 0% | $50,104,579 |
| VANGUARD CAPITAL MANAGEMENT LLC | 3.6% | 10,231,502 | 0% | 0% | $45,734,814 |
| Octagon Capital Advisors LP | 3.1% | 8,859,911 | 0% | 4.4% | $39,603,802 |
| Siren, L.L.C. | 3.1% | 8,829,913 | -13% | 1.1% | $39,469,711 |
| Polar Capital Holdings Plc | 2% | 5,654,340 | -29% | 0.11% | $25,274,900 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.9% | 5,531,955 | +2.7% | 0% | $24,732,183 |
| D. E. Shaw & Co., Inc. | 1.5% | 4,427,301 | +10% | 0.02% | $19,790,035 |
| BAKER BROS. ADVISORS LP | 1.4% | 4,004,756 | 0% | 0.1% | $17,901,259 |
| MILLENNIUM MANAGEMENT LLC | 1.1% | 3,281,820 | +3.2% | 0.01% | $14,669,735 |
| Casdin Capital, LLC | 1.1% | 3,250,000 | +117% | 1.1% | $14,527,500 |
| ADAR1 Capital Management, LLC | 1% | 2,979,429 | +19% | 0.81% | $13,318,048 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 1% | 2,883,301 | -23% | 0.02% | $12,888,355 |
| BARCLAYS PLC | 0.98% | 2,812,010 | -49% | 0% | $11,444,881 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0.95% | 2,722,165 | 0% | 0.14% | $12,168,078 |
| SG Americas Securities, LLC | 0.76% | 2,176,742 | +179% | 0.01% | $9,730,000 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 0.71% | 2,022,498 | 0% | 0% | $9,040,566 |
| RICE HALL JAMES & ASSOCIATES, LLC | 0.68% | 1,944,671 | +53% | 0.48% | $8,692,679 |
Quarter history
Institutional holders across reporting periods
Holder count, reported shares/value, and median price by quarter.
Periods
23
Latest
Q1 2026
Rows shown
1-23 of 23
| Period | 13F Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2026 Q1 | 264,720,110 | $1,182,044,534 | -$21,468,733 | $4.47 | 187 |
| 2025 Q4 | 269,009,134 | $1,479,387,583 | +$50,473,906 | $5.50 | 195 |
| 2025 Q3 | 264,455,712 | $864,768,038 | +$29,349,082 | $3.27 | 152 |
| 2025 Q2 | 257,684,976 | $595,324,582 | +$211,768,578 | $2.31 | 147 |
| 2025 Q1 | 166,761,354 | $231,855,383 | -$5,171,826 | $1.39 | 124 |
| 2024 Q4 | 167,381,791 | $289,604,775 | +$18,983,312 | $1.73 | 126 |
| 2024 Q3 | 156,893,147 | $315,365,141 | -$17,620,277 | $2.01 | 114 |
| 2024 Q2 | 158,086,076 | $354,139,573 | +$33,881,138 | $2.24 | 102 |
| 2024 Q1 | 140,148,555 | $402,080,424 | +$33,453,660 | $2.87 | 106 |
| 2023 Q4 | 130,129,882 | $230,288,972 | -$12,329,934 | $1.77 | 85 |
| 2023 Q3 | 129,862,060 | $410,364,849 | +$376,246,041 | $3.16 | 59 |
| 2023 Q2 | 13,698,356 | $9,051,371 | -$2,014,707 | $0.66 | 37 |
| 2023 Q1 | 16,687,605 | $13,286,354 | -$3,025,814 | $0.80 | 42 |
| 2022 Q4 | 19,375,255 | $43,785,515 | +$12,385,904 | $2.26 | 51 |
| 2022 Q3 | 13,927,007 | $27,020,000 | -$1,811,564 | $1.93 | 48 |
| 2022 Q2 | 14,700,530 | $54,695,000 | -$11,594,670 | $3.72 | 55 |
| 2022 Q1 | 17,015,055 | $110,894,239 | -$16,224,000 | $6.52 | 70 |
| 2021 Q4 | 18,503,286 | $215,562,592 | -$15,412,583 | $11.65 | 64 |
| 2021 Q3 | 19,436,846 | $361,910,267 | +$4,396,852 | $18.62 | 48 |
| 2021 Q2 | 18,320,557 | $388,394,891 | +$15,022,269 | $21.20 | 48 |
| 2021 Q1 | 17,661,042 | $358,518,075 | -$11,587,017 | $20.30 | 46 |
| 2020 Q4 | 17,998,551 | $475,216,635 | +$32,037,839 | $26.54 | 51 |
| 2020 Q3 | 16,580,732 | $366,712,000 | +$366,712,000 | $22.40 | 46 |