Adagio Medical Holdings, Inc. - Common Stock, par value $0.0001 per share (ADGM) Institutional Ownership

13F Institutional Holders and Ownership History from Q3 2024 to Q4 2025

Type / Class
Equity / Common Stock, par value $0.0001 per share
Symbol
ADGM on Nasdaq
Shares outstanding
21,148,193
Price per share
$1.00
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
16,645,650
Total reported value
$17,311,113
% of total 13F portfolios
0%
Share change
+5,007,110
Value change
+$4,994,220
Number of holders
21
Price from insider filings
$1.00
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Adagio Medical Holdings, Inc. - Common Stock, par value $0.0001 per share (ADGM) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
PERCEPTIVE ADVISORS LLC 58% -22% $14,555,572 15,321,655 0% Perceptive Advisors LLC 31 Dec 2025
Alyeska Investment Group, L.P. 9.9% $1,991,945 2,096,784 Alyeska Investment Group, L.P. 31 Dec 2025
Sio Capital Management, LLC 6.1% $1,224,038 1,288,461 Sio Capital Management, LLC 31 Dec 2025
ADAR1 Capital Management, LLC 5.7% $1,205,447 1,205,447 ADAR1 Capital Management, LLC 31 Dec 2025
RA CAPITAL MANAGEMENT, L.P. 7.2% 0% $1,656,000 1,200,000 0% RA Capital Management, L.P. 30 Jun 2025
Adage Capital Management, L.P. 6.9% +31% $2,085,247 +$467,363 1,058,501 +29% Adage Capital Management, L.P. 30 Sep 2025

As of 31 Dec 2025, 21 institutional investors reported holding 16,645,650 shares of Adagio Medical Holdings, Inc. - Common Stock, par value $0.0001 per share (ADGM). This represents 79% of the company’s total 21,148,193 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of Adagio Medical Holdings, Inc. - Common Stock, par value $0.0001 per share (ADGM) together control 79% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
PERCEPTIVE ADVISORS LLC 47% 9,876,576 0% 0.19% $10,271,639
Sio Capital Management, LLC 6.1% 1,288,461 0.22% $1,339,999
ADAGE CAPITAL PARTNERS GP, L.L.C. 6% 1,258,501 +19% 0% $1,308,841
Alyeska Investment Group, L.P. 5.5% 1,159,615 0% $1,206,000
ADAR1 Capital Management, LLC 5.5% 1,159,614 0.09% $1,205,999
SILVERARC CAPITAL MANAGEMENT, LLC 2.4% 515,384 0.08% $535,999
ARMISTICE CAPITAL, LLC 2.3% 478,000 0.01% $497,120
Hudson Bay Capital Management LP 1.4% 296,369 0% $308,224
Shaolin Capital Management LLC 0.81% 171,170 -4.9% 0.01% $178,017
Opaleye Management Inc. 0.52% 110,571 0% 0.02% $114,994
Affinity Asset Advisors, LLC 0.38% 80,000 0% 0.01% $83,200
VANGUARD GROUP INC 0.38% 79,451 +140% 0% $82,629
GEODE CAPITAL MANAGEMENT, LLC 0.32% 68,342 +89% 0% $71,075
TORONTO DOMINION BANK 0.12% 25,000 0% 0% $26,000
NORTHERN TRUST CORP 0.1% 21,598 0% $22,462
HRT FINANCIAL LP 0.09% 18,618 0% $19,000
XTX Topco Ltd 0.09% 18,103 0% $18,827
BANK OF AMERICA CORP /DE/ 0.05% 11,494 +39534% 0% $11,954
Tower Research Capital LLC (TRC) 0.04% 8,146 +291% 0% $8,472
Crewe Advisors LLC 0% 500 0% $520
MORGAN STANLEY 0% 137 0% $142
CITIGROUP INC 0% 0 -100% $0
RENAISSANCE TECHNOLOGIES LLC 0% 0 -100% $0
BARCLAYS PLC 0% 0 -100% $0
UBS Group AG 0% 0 -100% $0

Institutional Holders of Adagio Medical Holdings, Inc. - Common Stock, par value $0.0001 per share (ADGM) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 16,645,650 $17,311,113 +$4,994,220 $1.04 21
2025 Q3 11,638,540 $22,578,784 -$378,507 $1.94 15
2025 Q2 11,882,184 $14,927,921 +$160,006 $1.30 13
2025 Q1 11,593,031 $9,331,190 +$632,839 $0.80 14
2024 Q4 10,801,797 $11,342,157 -$3,360,595 $1.05 15
2024 Q3 12,019,550 $31,010,438 +$31,010,438 $2.58 12