| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 14.5% | $235M | 15.3M | ORBIMED ADVISORS LLC | 09 May 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | $169M | 10.4M | RA Capital Management, L.P. | 30 Sep 2025 | |||
| BAKER BROS. ADVISORS LP | 6.9% | $95.2M | 7.31M | Baker Bros. Advisors LP | 30 Jun 2025 | |||
| BlackRock, Inc. | 5.5% | $76.4M | 5.82M | BlackRock, Inc. | 30 Jun 2025 | |||
| JANUS HENDERSON GROUP PLC | 4.7% | -10% | $80.8M | -$8.5M | 4.98M | -9.52% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
| Paradigm Biocapital Advisors LP | 5% | $73M | 4.74M | Paradigm BioCapital Advisors LP | 27 Jan 2025 | |||
| PERCEPTIVE ADVISORS LLC | 4.4% | -28.3% | $60.5M | -$22.9M | 4.64M | -27.5% | Perceptive Advisors LLC | 30 Jun 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 112M | $1.82B | -$102M | $16.22 | 171 |
| 2025 Q2 | 119M | $1.56B | +$135M | $13.11 | 177 |
| 2025 Q1 | 105M | $2.32B | +$130M | $22.00 | 190 |
| 2024 Q4 | 98.9M | $2.64B | -$78.9M | $26.70 | 197 |
| 2024 Q3 | 101M | $2.7B | -$12.1M | $26.69 | 174 |
| 2024 Q2 | 102M | $1.83B | +$179M | $18.01 | 138 |
| 2024 Q1 | 91.6M | $1.67B | +$311M | $18.24 | 126 |
| 2023 Q4 | 79.6M | $871M | +$122M | $10.94 | 115 |
| 2023 Q3 | 68.4M | $392M | -$8.22M | $5.73 | 84 |
| 2023 Q2 | 69.5M | $539M | +$23.8M | $7.75 | 94 |
| 2023 Q1 | 66.5M | $443M | -$749K | $6.67 | 85 |
| 2022 Q4 | 66.5M | $594M | +$17.7M | $8.94 | 90 |
| 2022 Q3 | 64.4M | $634M | +$133M | $9.84 | 92 |
| 2022 Q2 | 51M | $406M | -$30.2M | $7.96 | 76 |
| 2022 Q1 | 54M | $524M | +$34M | $9.70 | 71 |
| 2021 Q4 | 50.2M | $768M | +$33.4M | $15.28 | 56 |
| 2021 Q3 | 48M | $796M | +$3.11M | $16.60 | 47 |
| 2021 Q2 | 46.3M | $985M | +$40.3M | $21.33 | 45 |
| 2021 Q1 | 45.7M | $1.48B | +$1.48B | $32.50 | 31 |