Security Snapshot

Edgewise Therapeutics, Inc. - Common Stock, $0.0001 par value per share (EWTX) Institutional Ownership

CUSIP: 28036F105

13F Institutional Holders and Ownership History from Q1 2021 to Q2 2026

Latest Period

Q2 2026

Institutions Reporting

226

Shares (Excl. Options)

119,194,438

Price

$40.63

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Latest holder snapshot 5 signals
Portfolio coverage rank
0.01%
Share change
+498,622
Value change
+$51,387,100
Number of holders
226
Issuer context Names, identifiers, and filing context for this profile. 3 identity fields
Shares outstanding
107,531,105
SEC-reported price per share
$44.31
Insider filing price
$44.31
13F Shares, Excluding Options vs Price
13F Value, Excluding Options
Total Investors

Key facts

  • EWTX - Edgewise Therapeutics, Inc. - Common Stock, $0.0001 par value per share is tracked under CUSIP 28036F105.
  • 226 institutions reported positions in Q2 2026.
  • 9 significant owners is listed from Schedule 13D/13G reporting.

Change

  • Holder count moved from 212 to 226 between Q1 2026 and Q2 2026.
  • SEC-reported value moved from $3,721,351,792 to $4,822,487,808.

Research use

  • You can quickly see who holds this security, then open quarter and manager detail pages for full evidence.
  • 13F and Schedule 13D/13G sections are kept together so you can cross-check institutional and beneficial ownership context.

Evidence

Source: SEC Form 13F

Latest holder context comes from 226 institutions filings for Q2 2026.

Open SEC evidence

Security key

28036F105

Latest holder period

Q2 2026

13F holders

226

13D/G owners

9

CIK / CUSIP context first

13D/G owners

Significant owners

Large-stake holder rows connected to Schedule 13D/G evidence.

Rows
9
Security
EWTX
Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
ORBIMED ADVISORS LLC 14% $234,894,152 15,252,867 ORBIMED ADVISORS LLC 09 May 2025
Paradigm Biocapital Advisors LP 9.5% +55% $493,917,249 +$177,649,746 10,215,455 +56% Paradigm BioCapital Advisors LP 30 Jun 2026
RA CAPITAL MANAGEMENT, L.P. 7.8% -21% $405,788,496 -$98,426,433 8,392,730 -20% RA Capital Management, L.P. 30 Jun 2026
JANUS HENDERSON GROUP PLC 5.5% +16% $197,165,481 +$31,204,379 5,915,556 +19% JANUS HENDERSON GROUP PLC 31 Mar 2026
BlackRock, Inc. 5.5% $76,363,411 5,824,866 BlackRock, Inc. 30 Jun 2025
FMR LLC 5.1% $265,399,677 5,489,135 FMR LLC 30 Jun 2026
Novo Holdings A/S 4.9% $168,525,535 5,350,000 Novo Holdings A/S 23 Apr 2026
PERCEPTIVE ADVISORS LLC 4.4% -28% $60,458,535 -$22,875,429 4,639,949 -27% Perceptive Advisors LLC 30 Jun 2025
BAKER BROS. ADVISORS LP 3.4% -50% $178,978,114 -$174,264,085 3,701,719 -49% Baker Bros. Advisors LP 30 Jun 2026

As of 30 Jun 2026, 226 institutional investors reported holding 119,194,438 shares of Edgewise Therapeutics, Inc. - Common Stock, $0.0001 par value per share (EWTX). This represents 111% of the company’s total 107,531,105 outstanding shares.

13F concentration

Top 25 institutional shareholders

Largest 13F positions for this security by reported shares and value.

Top holder share
93%
Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
ORBIMED ADVISORS LLC 14% 15,518,492 0% 12% $630,516,330
Paradigm Biocapital Advisors LP 9.5% 10,215,455 +39% 7.8% $415,053,937
RA CAPITAL MANAGEMENT, L.P. 7.8% 8,392,730 -20% 3% $340,996,620
BlackRock, Inc. 6.1% 6,606,336 +2.1% 0% $268,415,431
Jupiter Topco LLC 5.6% 6,075,331 0% 0.1% $246,945,299
FMR LLC 5.1% 5,489,135 +440% 0.01% $223,023,556
NOVO HOLDINGS A/S 5% 5,350,000 0% 13% $217,370,500
Driehaus Capital Management LLC 4.4% 4,728,623 +5.6% 1.1% $192,123,952
PERCEPTIVE ADVISORS LLC 4.1% 4,373,974 -1.1% 2.8% $177,714,564
VANGUARD CAPITAL MANAGEMENT LLC 3.6% 3,860,670 +1.9% 0% $156,859,022
BAKER BROS. ADVISORS LP 3.4% 3,701,719 -44% 0.75% $150,400,843
Siren, L.L.C. 3% 3,184,629 -28% 2.6% $129,391,476
Cormorant Asset Management, LP 2.3% 2,510,000 -23% 5.2% $101,981,300
GEODE CAPITAL MANAGEMENT, LLC 2% 2,174,051 +21% 0% $88,348,054
ALLIANCEBERNSTEIN L.P. 2% 2,119,024 +23% 0.02% $66,749,256
Integral Health Asset Management, LLC 1.9% 2,000,000 +25% 3.3% $81,260,000
BRAIDWELL LP 1.9% 1,996,965 -15% 3% $81,136,688
MORGAN STANLEY 1.8% 1,948,597 -13% 0% $79,171,495
STATE STREET CORP 1.7% 1,827,927 +6.5% 0% $74,268,674
MPM BIOIMPACT LLC 1.5% 1,620,780 -2.4% 4% $65,852,291
BANK OF AMERICA CORP /DE/ 1.4% 1,558,260 +17% 0% $63,312,105
Qube Research & Technologies Ltd 1.2% 1,252,507 +52% 0.06% $50,889,359
DIMENSIONAL FUND ADVISORS LP 1.1% 1,139,726 -6.6% 0.01% $46,309,097
AMERICAN CENTURY COMPANIES INC 1% 1,127,078 -1.8% 0.02% $45,793,233
First Light Asset Management, LLC 1% 1,095,171 +9.3% 2.7% $44,496,798

Quarter history

Institutional holders across reporting periods

Holder count, reported shares/value, and median price by quarter.

Periods
22
Latest
Q2 2026
Rows shown
1-22 of 22
Period 13F Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2026 Q2 119,194,438 $4,822,487,808 +$51,387,100 $40.63 226
2026 Q1 118,515,156 $3,721,351,792 -$100,536,601 $31.50 212
2025 Q4 121,825,813 $3,022,606,371 +$263,739,414 $24.82 199
2025 Q3 111,964,035 $1,816,272,411 -$102,066,033 $16.22 172
2025 Q2 118,737,861 $1,557,153,070 +$135,315,946 $13.11 177
2025 Q1 105,289,941 $2,320,227,206 +$130,326,516 $22.00 190
2024 Q4 98,918,436 $2,640,722,866 -$78,891,260 $26.70 197
2024 Q3 101,289,495 $2,703,865,523 -$12,073,061 $26.69 174
2024 Q2 101,617,706 $1,830,101,707 +$179,027,088 $18.01 138
2024 Q1 91,602,360 $1,670,777,013 +$311,144,088 $18.24 126
2023 Q4 79,647,397 $871,350,413 +$122,344,417 $10.94 115
2023 Q3 68,438,296 $392,172,292 -$8,215,044 $5.73 84
2023 Q2 69,494,963 $538,802,876 +$23,832,932 $7.75 94
2023 Q1 66,455,672 $443,090,314 -$748,812 $6.67 85
2022 Q4 66,466,915 $594,208,237 +$17,736,112 $8.94 90
2022 Q3 64,390,889 $633,608,275 +$132,537,303 $9.84 92
2022 Q2 50,965,041 $405,682,841 -$30,249,561 $7.96 76
2022 Q1 53,964,373 $523,513,727 +$33,997,944 $9.70 71
2021 Q4 50,239,434 $767,640,710 +$33,441,771 $15.28 56
2021 Q3 48,038,152 $795,758,000 +$3,108,242 $16.60 47
2021 Q2 46,323,514 $984,550,000 +$40,348,386 $21.33 45
2021 Q1 45,681,359 $1,477,378,000 +$1,477,377,994 $32.50 31
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