| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 14.5% | $234,894,152 | 15,252,867 | ORBIMED ADVISORS LLC | 09 May 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | $169,149,248 | 10,428,437 | RA Capital Management, L.P. | 30 Sep 2025 | |||
| BAKER BROS. ADVISORS LP | 6.9% | $95,196,398 | 7,305,940 | Baker Bros. Advisors LP | 30 Jun 2025 | |||
| BlackRock, Inc. | 5.5% | $76,363,411 | 5,824,866 | BlackRock, Inc. | 30 Jun 2025 | |||
| JANUS HENDERSON GROUP PLC | 4.7% | -10% | $80,764,749 | -$8,499,572 | 4,979,331 | -9.52% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
| Paradigm Biocapital Advisors LP | 5% | $72,979,507 | 4,738,929 | Paradigm BioCapital Advisors LP | 27 Jan 2025 | |||
| PERCEPTIVE ADVISORS LLC | 4.4% | -28.3% | $60,458,535 | -$22,875,429 | 4,639,949 | -27.5% | Perceptive Advisors LLC | 30 Jun 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 111,964,031 | $1,816,272,346 | -$102,065,530 | $16.22 | 171 |
| 2025 Q2 | 118,737,861 | $1,557,153,070 | +$135,315,946 | $13.11 | 177 |
| 2025 Q1 | 105,289,941 | $2,320,227,206 | +$130,326,516 | $22.00 | 190 |
| 2024 Q4 | 98,918,436 | $2,640,722,866 | -$78,891,260 | $26.70 | 197 |
| 2024 Q3 | 101,289,495 | $2,703,865,523 | -$12,073,061 | $26.69 | 174 |
| 2024 Q2 | 101,617,706 | $1,830,101,707 | +$179,027,088 | $18.01 | 138 |
| 2024 Q1 | 91,602,360 | $1,670,777,013 | +$311,144,088 | $18.24 | 126 |
| 2023 Q4 | 79,647,397 | $871,350,413 | +$122,344,417 | $10.94 | 115 |
| 2023 Q3 | 68,438,296 | $392,172,292 | -$8,215,044 | $5.73 | 84 |
| 2023 Q2 | 69,494,963 | $538,802,876 | +$23,832,932 | $7.75 | 94 |
| 2023 Q1 | 66,455,672 | $443,090,314 | -$748,812 | $6.67 | 85 |
| 2022 Q4 | 66,466,915 | $594,208,237 | +$17,736,112 | $8.94 | 90 |
| 2022 Q3 | 64,390,889 | $633,608,275 | +$132,537,303 | $9.84 | 92 |
| 2022 Q2 | 50,965,041 | $405,682,841 | -$30,249,561 | $7.96 | 76 |
| 2022 Q1 | 53,964,373 | $523,513,727 | +$33,997,944 | $9.70 | 71 |
| 2021 Q4 | 50,239,434 | $767,640,710 | +$33,441,771 | $15.28 | 56 |
| 2021 Q3 | 48,038,152 | $795,758,000 | +$3,108,242 | $16.60 | 47 |
| 2021 Q2 | 46,323,514 | $984,550,000 | +$40,348,386 | $21.33 | 45 |
| 2021 Q1 | 45,681,359 | $1,477,378,000 | +$1,477,377,994 | $32.50 | 31 |