Edgewise Therapeutics, Inc. - Common Stock, $0.0001 par value per share (EWTX) Institutional Ownership

13F Institutional Holders and Ownership History from Q1 2021 to Q4 2025

Type / Class
Equity / Common Stock, $0.0001 par value per share
Symbol
EWTX on Nasdaq
Shares outstanding
105,503,387
Price per share
$28.78
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
121,818,963
Total reported value
$3,022,436,429
% of total 13F portfolios
0.01%
Share change
+10,276,133
Value change
+$263,704,102
Number of holders
194
Price from insider filings
$28.78
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Edgewise Therapeutics, Inc. - Common Stock, $0.0001 par value per share (EWTX) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
ORBIMED ADVISORS LLC 14% $234,894,152 15,252,867 ORBIMED ADVISORS LLC 09 May 2025
RA CAPITAL MANAGEMENT, L.P. 9.9% $169,149,248 10,428,437 RA Capital Management, L.P. 30 Sep 2025
BAKER BROS. ADVISORS LP 6.9% $95,196,398 7,305,940 Baker Bros. Advisors LP 30 Jun 2025
Paradigm Biocapital Advisors LP 6.2% +24% $161,371,651 +$44,462,272 6,541,210 +38% Paradigm BioCapital Advisors LP 31 Dec 2025
BlackRock, Inc. 5.5% $76,363,411 5,824,866 BlackRock, Inc. 30 Jun 2025
JANUS HENDERSON GROUP PLC 4.7% -10% $80,764,749 -$8,499,572 4,979,331 -9.5% JANUS HENDERSON GROUP PLC 30 Sep 2025
PERCEPTIVE ADVISORS LLC 4.4% -28% $60,458,535 -$22,875,429 4,639,949 -27% Perceptive Advisors LLC 30 Jun 2025

As of 31 Dec 2025, 194 institutional investors reported holding 121,818,963 shares of Edgewise Therapeutics, Inc. - Common Stock, $0.0001 par value per share (EWTX). This represents 115% of the company’s total 105,503,387 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of Edgewise Therapeutics, Inc. - Common Stock, $0.0001 par value per share (EWTX) together control 97% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
ORBIMED ADVISORS LLC 15% 15,518,492 0% 8.2% $385,091,379
RA CAPITAL MANAGEMENT, L.P. 9.9% 10,428,437 0% 2.7% $258,781,664
BlackRock, Inc. 6.3% 6,630,576 +4.4% 0% $164,537,741
BAKER BROS. ADVISORS LP 6.2% 6,575,940 -10% 0.96% $163,181,951
Paradigm Biocapital Advisors LP 6.2% 6,541,210 +6% 4.3% $162,320,126
NOVO HOLDINGS A/S 5.1% 5,350,000 0% 10% $132,760,250
BRAIDWELL LP 4.9% 5,210,831 0% 4.1% $129,306,771
VANGUARD GROUP INC 4.6% 4,871,624 +1.4% 0% $120,889,349
JANUS HENDERSON GROUP PLC 4.3% 4,566,850 -8.3% 0.05% $113,326,384
Siren, L.L.C. 4.3% 4,529,990 +16% 3.4% $112,411,702
PERCEPTIVE ADVISORS LLC 4.2% 4,457,974 +17% 2% $110,624,625
Driehaus Capital Management LLC 4% 4,191,193 +88% 0.71% $104,004,458
Cormorant Asset Management, LP 3.1% 3,285,000 -18% 4.6% $81,517,275
MORGAN STANLEY 2.8% 2,910,881 +235% 0% $72,233,511
UBS Group AG 2% 2,117,073 +1755% 0.01% $52,535,166
GEODE CAPITAL MANAGEMENT, LLC 1.7% 1,746,222 +1.7% 0% $43,340,399
STATE STREET CORP 1.6% 1,717,343 +1% 0% $42,615,867
MPM BIOIMPACT LLC 1.6% 1,655,256 -3.8% 4.7% $41,075,178
First Light Asset Management, LLC 1.5% 1,573,701 +11% 3% $39,051,392
Bellevue Group AG 1.4% 1,528,518 -45% 0.72% $37,930,174
Integral Health Asset Management, LLC 1.4% 1,500,000 0% 1.9% $37,222,500
BANK OF AMERICA CORP /DE/ 1.4% 1,474,797 +359% 0% $36,597,088
DIMENSIONAL FUND ADVISORS LP 1.2% 1,213,657 +2.6% 0.01% $30,114,975
AMERICAN CENTURY COMPANIES INC 1.1% 1,186,467 +8.3% 0.01% $29,442,210
ALLIANCEBERNSTEIN L.P. 0.98% 1,036,170 +1241% 0.01% $25,712,559

Institutional Holders of Edgewise Therapeutics, Inc. - Common Stock, $0.0001 par value per share (EWTX) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 121,818,963 $3,022,436,429 +$263,704,102 $24.82 194
2025 Q3 111,964,035 $1,816,272,411 -$102,065,465 $16.22 172
2025 Q2 118,737,861 $1,557,153,070 +$135,315,946 $13.11 177
2025 Q1 105,289,941 $2,320,227,206 +$130,326,516 $22.00 190
2024 Q4 98,918,436 $2,640,722,866 -$78,891,260 $26.70 197
2024 Q3 101,289,495 $2,703,865,523 -$12,073,061 $26.69 174
2024 Q2 101,617,706 $1,830,101,707 +$179,027,088 $18.01 138
2024 Q1 91,602,360 $1,670,777,013 +$311,144,088 $18.24 126
2023 Q4 79,647,397 $871,350,413 +$122,344,417 $10.94 115
2023 Q3 68,438,296 $392,172,292 -$8,215,044 $5.73 84
2023 Q2 69,494,963 $538,802,876 +$23,832,932 $7.75 94
2023 Q1 66,455,672 $443,090,314 -$748,812 $6.67 85
2022 Q4 66,466,915 $594,208,237 +$17,736,112 $8.94 90
2022 Q3 64,390,889 $633,608,275 +$132,537,303 $9.84 92
2022 Q2 50,965,041 $405,682,841 -$30,249,561 $7.96 76
2022 Q1 53,964,373 $523,513,727 +$33,997,944 $9.70 71
2021 Q4 50,239,434 $767,640,710 +$33,441,771 $15.28 56
2021 Q3 48,038,152 $795,758,000 +$3,108,242 $16.60 47
2021 Q2 46,323,514 $984,550,000 +$40,348,386 $21.33 45
2021 Q1 45,681,359 $1,477,378,000 +$1,477,377,994 $32.50 31