| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 16% | $43,800,272 | 11,934,679 | Perceptive Advisors LLC | 19 Feb 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | $43,346,504 | 7,997,510 | RA Capital Management, L.P. | 12 Aug 2025 | |||
| Invus Global Management, LLC | 9.6% | +2.2% | $27,216,371 | +$13,457,391 | 7,415,905 | +98% | Raymond Debbane | 31 Mar 2025 |
| BlackRock, Inc. | 6.1% | $22,954,472 | 4,712,573 | BlackRock, Inc. | 30 Jun 2025 | |||
| Adage Capital Management, L.P. | 5.1% | -39% | $24,680,000 | -$16,840,916 | 4,000,000 | -41% | Adage Capital Management, L.P. | 30 Sep 2025 |
| Vestal Point Capital, LP | 2.3% | $6,435,558 | 1,753,558 | Vestal Point Capital, LP | 31 Mar 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 15% | 11,833,539 | -0.61% | 2.1% | $73,012,936 |
| Bain Capital Life Sciences Investors, LLC | 10% | 7,911,669 | 0% | 3.2% | $48,814,998 |
| Siren, L.L.C. | 9.5% | 7,415,905 | 0% | 1.8% | $45,756,134 |
| RA CAPITAL MANAGEMENT, L.P. | 7.5% | 5,811,423 | +0% | 0.44% | $35,856,480 |
| BlackRock, Inc. | 6.1% | 4,725,118 | -4% | 0% | $29,153,978 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5.1% | 4,000,000 | -41% | 0.04% | $24,680,000 |
| VANGUARD GROUP INC | 4% | 3,083,850 | -8.4% | 0% | $19,027,355 |
| Vestal Point Capital, LP | 3.8% | 2,975,000 | +98% | 0.83% | $18,355,750 |
| FMR LLC | 3.7% | 2,914,127 | -8.3% | 0% | $17,980,164 |
| CITADEL ADVISORS LLC | 3.3% | 2,592,697 | +2.8% | 0.01% | $15,996,940 |
| Redmile Group, LLC | 2.4% | 1,899,342 | -0.87% | 1.1% | $11,718,940 |
| Nantahala Capital Management, LLC | 2.2% | 1,699,258 | -0.24% | 0.65% | $10,484,422 |
| Alyeska Investment Group, L.P. | 2.2% | 1,682,805 | +2.6% | 0.03% | $10,382,906 |
| MPM BIOIMPACT LLC | 2.1% | 1,634,569 | 0% | 1.7% | $10,085,291 |
| FRANKLIN RESOURCES INC | 2.1% | 1,599,232 | +0% | 0% | $9,867,261 |
| Point72 Asset Management, L.P. | 1.7% | 1,333,005 | +5.3% | 0.02% | $8,224,641 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.7% | 1,287,243 | -15% | 0% | $7,943,954 |
| STATE STREET CORP | 1.4% | 1,093,299 | +15% | 0% | $6,745,655 |
| Finepoint Capital LP | 1.2% | 961,251 | 0% | 1.1% | $5,930,919 |
| ARMISTICE CAPITAL, LLC | 1.2% | 936,000 | +134% | 0.18% | $5,775,120 |
| MILLENNIUM MANAGEMENT LLC | 1.2% | 909,701 | -17% | 0% | $5,612,855 |
| BANK OF AMERICA CORP /DE/ | 1% | 789,996 | -4.2% | 0% | $4,874,275 |
| Balyasny Asset Management L.P. | 0.94% | 732,608 | +50% | 0.01% | $4,520,191 |
| UBS Group AG | 0.93% | 724,145 | -6.2% | 0% | $4,467,975 |
| GOLDMAN SACHS GROUP INC | 0.87% | 676,627 | +77% | 0% | $4,174,788 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 824 | $4,648 | +$926 | $5.64 | 2 |
| 2025 Q3 | 81,357,989 | $501,971,248 | -$1,773,265 | $6.17 | 122 |
| 2025 Q2 | 82,208,819 | $400,360,815 | +$32,116,218 | $4.87 | 110 |
| 2025 Q1 | 78,846,500 | $291,701,746 | +$157,692,840 | $3.70 | 121 |
| 2024 Q4 | 36,331,707 | $145,326,212 | -$2,638,776 | $4.00 | 86 |
| 2024 Q3 | 35,844,916 | $249,839,838 | -$25,277,188 | $6.97 | 90 |
| 2024 Q2 | 37,594,933 | $213,228,886 | +$13,669,240 | $5.67 | 78 |
| 2024 Q1 | 34,987,922 | $465,886,559 | +$255,393,890 | $13.32 | 52 |
| 2023 Q4 | 16,633,699 | $102,223,957 | +$4,578,230 | $6.14 | 38 |
| 2023 Q3 | 16,169,847 | $40,746,223 | -$462,509 | $2.52 | 34 |
| 2023 Q2 | 16,340,241 | $85,622,446 | +$3,108,792 | $5.24 | 34 |
| 2023 Q1 | 15,773,407 | $74,764,734 | +$2,205,404 | $4.74 | 35 |
| 2022 Q4 | 15,014,401 | $80,763,090 | +$80,763,090 | $5.38 | 30 |
| 2020 Q4 | 0 | $0 | -$623,259 | 0 | |
| 2020 Q3 | 307,024 | $623,259 | +$623,259 | $2.03 | 1 |