| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BIOTECHNOLOGY VALUE FUND L P | 10% | +31% | $76,791,609 | +$24,465,506 | 8,677,018 | +47% | BVF PARTNERS L P/IL | 30 Sep 2025 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 9.4% | +39% | $49,222,110 | +$15,381,900 | 7,561,000 | +45% | SUVRETTA CAPITAL MANAGEMENT, LLC | 31 Mar 2025 |
| BlackRock, Inc. | 7.8% | -24% | $41,202,116 | -$10,448,902 | 6,329,050 | -20% | BlackRock, Inc. | 31 Mar 2025 |
| ARMISTICE CAPITAL, LLC | 5.4% | -28% | $41,347,200 | -$16,815,000 | 4,672,000 | -29% | Armistice Capital, LLC | 30 Sep 2025 |
| EcoR1 Capital, LLC | 4.8% | $23,520,000 | 4,200,000 | EcoR1 Capital, LLC | 30 Jun 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 4.9% | $26,070,011 | 4,004,610 | RA Capital Management, L.P. | 31 Mar 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| BlackRock, Inc. | 11% | 9,515,135 | +0.47% | 0% | $84,208,945 |
| BVF INC/IL | 9.9% | 8,617,162 | +11% | 3.1% | $76,261,884 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 9.3% | 8,116,000 | 0% | 2.2% | $71,826,600 |
| VANGUARD GROUP INC | 6.3% | 5,468,522 | +2.2% | 0% | $48,396,420 |
| ARMISTICE CAPITAL, LLC | 5.4% | 4,672,000 | -25% | 1.3% | $41,347,200 |
| STATE STREET CORP | 3.8% | 3,343,131 | +10% | 0% | $29,586,709 |
| Prosight Management, LP | 3.2% | 2,758,516 | -13% | 5.9% | $24,412,867 |
| GOLDMAN SACHS GROUP INC | 3% | 2,614,726 | +180% | 0% | $23,140,325 |
| AQR CAPITAL MANAGEMENT LLC | 2.6% | 2,242,192 | +138% | 0.01% | $19,843,399 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 2.6% | 2,224,590 | +102% | 0.08% | $19,687,622 |
| MILLENNIUM MANAGEMENT LLC | 2.4% | 2,093,702 | -20% | 0.01% | $18,529,263 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.4% | 2,047,926 | +1.7% | 0% | $18,127,511 |
| MORGAN STANLEY | 2.1% | 1,813,064 | -8.6% | 0% | $16,045,621 |
| Qube Research & Technologies Ltd | 2% | 1,712,716 | -10% | 0.02% | $15,157,537 |
| ALETHEA CAPITAL MANAGEMENT, LLC | 1.6% | 1,388,794 | +46% | 7.9% | $12,290,827 |
| Assenagon Asset Management S.A. | 1.5% | 1,265,030 | +38% | 0.02% | $11,195,516 |
| DIMENSIONAL FUND ADVISORS LP | 1.3% | 1,139,365 | -8.3% | 0% | $10,083,861 |
| ACADIAN ASSET MANAGEMENT LLC | 1.2% | 1,060,829 | +22% | 0.02% | $9,387,000 |
| ALGERT GLOBAL LLC | 1.2% | 1,011,945 | -5.4% | 0.15% | $8,956,000 |
| EcoR1 Capital, LLC | 1% | 872,500 | -79% | 0.37% | $7,721,625 |
| RENAISSANCE TECHNOLOGIES LLC | 0.99% | 865,310 | -18% | 0.01% | $7,657,994 |
| CITADEL ADVISORS LLC | 0.93% | 808,818 | +122% | 0.01% | $7,158,040 |
| NORTHERN TRUST CORP | 0.87% | 753,600 | +8.6% | 0% | $6,669,361 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.82% | 711,896 | +1.8% | 0% | $6,300,280 |
| AMERICAN CENTURY COMPANIES INC | 0.77% | 669,046 | +187% | 0% | $5,921,057 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 1,437,394 | $14,817,611 | -$30,746 | $10.39 | 8 |
| 2025 Q3 | 83,953,188 | $743,091,012 | +$26,560,575 | $8.85 | 198 |
| 2025 Q2 | 82,161,271 | $474,076,451 | +$3,886,077 | $5.77 | 180 |
| 2025 Q1 | 80,481,583 | $531,240,145 | -$1,742,391 | $6.60 | 183 |
| 2024 Q4 | 78,800,102 | $686,302,860 | -$217,671,932 | $8.71 | 184 |
| 2024 Q3 | 82,360,607 | $1,606,956,703 | +$4,044,498 | $19.54 | 178 |
| 2024 Q2 | 80,489,635 | $1,657,260,003 | -$4,649,743 | $20.59 | 173 |
| 2024 Q1 | 80,704,151 | $1,721,386,349 | +$47,334,824 | $21.33 | 162 |
| 2023 Q4 | 78,750,714 | $1,132,429,796 | +$48,405,539 | $14.38 | 138 |
| 2023 Q3 | 75,320,060 | $686,894,075 | -$2,210,555 | $9.12 | 131 |
| 2023 Q2 | 75,143,461 | $795,074,726 | +$20,118,060 | $10.58 | 147 |
| 2023 Q1 | 72,452,228 | $885,285,317 | +$27,367,401 | $12.23 | 140 |
| 2022 Q4 | 70,164,281 | $870,596,716 | -$25,367,145 | $12.41 | 139 |
| 2022 Q3 | 71,584,721 | $977,803,865 | -$10,119,008 | $13.66 | 144 |
| 2022 Q2 | 68,658,415 | $1,258,498,156 | +$54,233,601 | $18.33 | 142 |
| 2022 Q1 | 65,777,551 | $1,057,605,942 | +$39,092,796 | $16.08 | 142 |
| 2021 Q4 | 64,108,565 | $897,784,334 | -$107,625,141 | $14.00 | 143 |
| 2021 Q3 | 66,738,474 | $1,250,027,023 | -$22,664,956 | $18.73 | 149 |
| 2021 Q2 | 67,619,494 | $1,409,907,095 | -$33,759,405 | $20.85 | 163 |
| 2021 Q1 | 68,584,982 | $1,942,401,972 | +$106,818,236 | $28.27 | 162 |
| 2020 Q4 | 65,052,975 | $2,124,984,562 | +$353,968,960 | $32.66 | 192 |
| 2020 Q3 | 53,818,393 | $1,648,931,451 | +$50,643,099 | $30.64 | 160 |
| 2020 Q2 | 52,442,231 | $855,540,393 | +$213,208,168 | $16.30 | 129 |
| 2020 Q1 | 39,802,987 | $394,470,751 | +$5,045,270 | $9.95 | 113 |
| 2019 Q4 | 38,979,999 | $536,059,777 | -$17,580,300 | $13.75 | 125 |
| 2019 Q3 | 40,174,979 | $609,372,943 | +$18,475,235 | $15.17 | 114 |
| 2019 Q2 | 38,684,419 | $761,718,678 | +$133,021,751 | $19.69 | 121 |
| 2019 Q1 | 32,044,753 | $531,121,734 | -$3,584,064 | $16.59 | 100 |
| 2018 Q4 | 32,415,330 | $454,789,379 | -$2,761,213 | $14.04 | 95 |
| 2018 Q3 | 30,235,029 | $529,138,565 | +$7,587,244 | $17.50 | 112 |
| 2018 Q2 | 29,714,074 | $540,689,653 | +$112,569,821 | $18.20 | 108 |
| 2018 Q1 | 23,570,284 | $441,929,475 | +$77,404,250 | $18.75 | 98 |
| 2017 Q4 | 19,535,236 | $298,877,651 | +$581,471 | $15.30 | 73 |
| 2017 Q3 | 19,416,540 | $290,234,810 | +$128,771,717 | $14.95 | 64 |
| 2017 Q2 | 10,813,395 | $100,551,904 | +$4,771,007 | $9.30 | 42 |
| 2017 Q1 | 10,310,503 | $90,718,000 | +$4,182,413 | $8.80 | 34 |
| 2016 Q4 | 9,877,148 | $58,241,000 | +$736,496 | $5.90 | 29 |
| 2016 Q3 | 9,748,853 | $60,931,000 | +$2,850,289 | $6.25 | 25 |
| 2016 Q2 | 9,319,042 | $25,248,000 | -$3,677,975 | $2.71 | 25 |
| 2016 Q1 | 10,225,954 | $41,413,000 | -$249,669 | $4.05 | 20 |
| 2015 Q4 | 10,246,869 | $86,073,000 | +$80,324,000 | $8.40 | 14 |