| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BIOTECHNOLOGY VALUE FUND L P | 9.99% | +31.1% | $76.8M | $24.5M | 8.68M | +46.8% | BVF PARTNERS L P/IL | Sep 30, 2025 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 9.4% | +38.6% | $49.2M | $15.4M | 7.56M | +45.5% | SUVRETTA CAPITAL MANAGEMENT, LLC | Mar 31, 2025 |
| BlackRock, Inc. | 7.8% | -24% | $41.2M | -$10.4M | 6.33M | -20.2% | BlackRock, Inc. | Mar 31, 2025 |
| ARMISTICE CAPITAL, LLC | 5.37% | -27.8% | $41.3M | -$16.8M | 4.67M | -28.9% | Armistice Capital, LLC | Sep 30, 2025 |
| EcoR1 Capital, LLC | 4.8% | $23.5M | 4.2M | EcoR1 Capital, LLC | Jun 30, 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 4.9% | $26.1M | 4M | RA Capital Management, L.P. | Mar 31, 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 84M | $743M | +$26.6M | $8.85 | 199 |
| 2025 Q2 | 82.2M | $474M | +$3.89M | $5.77 | 180 |
| 2025 Q1 | 80.5M | $531M | -$1.74M | $6.60 | 183 |
| 2024 Q4 | 78.8M | $686M | -$218M | $8.71 | 184 |
| 2024 Q3 | 82.4M | $1.61B | +$3.96M | $19.54 | 178 |
| 2024 Q2 | 80.5M | $1.66B | -$4.56M | $20.59 | 173 |
| 2024 Q1 | 80.7M | $1.72B | +$46.7M | $21.33 | 162 |
| 2023 Q4 | 77.1M | $1.11B | +$24.4M | $14.38 | 137 |
| 2023 Q3 | 75.3M | $687M | -$2.21M | $9.12 | 130 |
| 2023 Q2 | 75.1M | $795M | +$20.1M | $10.58 | 148 |
| 2023 Q1 | 72.4M | $885M | +$27.4M | $12.23 | 140 |
| 2022 Q4 | 70.1M | $870M | -$25.4M | $12.41 | 137 |
| 2022 Q3 | 71.5M | $977M | -$9.89M | $13.66 | 143 |
| 2022 Q2 | 68.6M | $1.26B | +$54.2M | $18.33 | 142 |
| 2022 Q1 | 65.8M | $1.06B | +$39.6M | $16.08 | 141 |
| 2021 Q4 | 64.1M | $897M | -$108M | $14.00 | 144 |
| 2021 Q3 | 66.7M | $1.25B | -$22.7M | $18.73 | 151 |
| 2021 Q2 | 67.6M | $1.41B | -$33.8M | $20.85 | 163 |
| 2021 Q1 | 68.5M | $1.94B | +$107M | $28.27 | 161 |
| 2020 Q4 | 65M | $2.12B | +$356M | $32.66 | 194 |
| 2020 Q3 | 53.7M | $1.65B | +$52.4M | $30.64 | 159 |
| 2020 Q2 | 52.3M | $853M | +$213M | $16.30 | 128 |
| 2020 Q1 | 39.6M | $393M | +$5.05M | $9.95 | 112 |
| 2019 Q4 | 38.8M | $534M | -$19.4M | $13.75 | 125 |
| 2019 Q3 | 40.1M | $609M | +$18.5M | $15.17 | 113 |
| 2019 Q2 | 38.6M | $761M | +$132M | $19.69 | 120 |
| 2019 Q1 | 32M | $531M | -$3.58M | $16.59 | 100 |
| 2018 Q4 | 32.4M | $455M | -$2.76M | $14.04 | 94 |
| 2018 Q3 | 30.2M | $529M | +$7.59M | $17.50 | 112 |
| 2018 Q2 | 29.7M | $541M | +$113M | $18.20 | 108 |
| 2018 Q1 | 23.6M | $442M | +$77.4M | $18.75 | 97 |
| 2017 Q4 | 19.5M | $299M | +$581K | $15.30 | 73 |
| 2017 Q3 | 19.4M | $290M | +$129M | $14.95 | 64 |
| 2017 Q2 | 10.8M | $101M | +$4.77M | $9.30 | 42 |
| 2017 Q1 | 10.3M | $90.7M | +$4.18M | $8.80 | 34 |
| 2016 Q4 | 9.88M | $58.2M | +$736K | $5.90 | 29 |
| 2016 Q3 | 9.75M | $60.9M | +$2.85M | $6.25 | 25 |
| 2016 Q2 | 9.32M | $25.2M | -$3.68M | $2.71 | 25 |
| 2016 Q1 | 10.2M | $40.7M | -$956K | $4.05 | 20 |
| 2015 Q4 | 10.2M | $86.1M | +$80.3M | $8.40 | 14 |