| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 10% | +38% | $53,623,911 | +$20,798,926 | 3,249,934 | +63% | Perceptive Advisors LLC | 31 Dec 2025 |
| Commodore Capital LP | 9.9% | +1% | $53,552,862 | +$913,456 | 3,245,628 | +1.7% | Commodore Capital LP | 31 Dec 2025 |
| Point72 Asset Management, L.P. | 8.9% | +27% | $46,600,538 | +$15,121,326 | 2,824,275 | +48% | Steven A. Cohen | 31 Dec 2025 |
| Vestal Point Capital, LP | 8% | $41,002,500 | 2,485,000 | Vestal Point Capital, LP | 31 Dec 2025 | |||
| ARMISTICE CAPITAL, LLC | 4.9% | -16% | $23,546,880 | -$981,120 | 1,536,000 | -4% | Armistice Capital, LLC | 31 Dec 2025 |
| FMR LLC | 4.7% | $2,885,445 | 1,265,546 | FMR LLC | 31 Dec 2024 | |||
| K2 HealthVentures Equity Trust LLC | 2.4% | -53% | $13,018,418 | -$13,676,190 | 788,995 | -51% | K2 HealthVentures Equity Trust LLC | 31 Dec 2025 |
| BlackRock, Inc. | 2.1% | $1,234,213 | 561,363 | BlackRock, Inc. | 30 Jun 2025 |
As of 31 Dec 2025, 95 institutional investors reported holding 24,486,977 shares of Alto Neuroscience, Inc. - Common Stock, $0.0001 par value per share (ANRO). This represents 79% of the company’s total 31,093,117 outstanding shares.
The largest institutional shareholders of Alto Neuroscience, Inc. - Common Stock, $0.0001 par value per share (ANRO) together control 72% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Alpha Wave Global, LP | 12% | 3,707,757 | 0% | 8.1% | $65,998,075 |
| Vestal Point Capital, LP | 8% | 2,485,000 | +162% | 1.6% | $44,233,000 |
| Commodore Capital LP | 5.9% | 1,823,196 | 2.2% | $32,452,889 | |
| PERCEPTIVE ADVISORS LLC | 5.7% | 1,784,393 | +1049% | 0.58% | $31,762,195 |
| Point72 Asset Management, L.P. | 5.2% | 1,606,954 | +21% | 0.04% | $28,603,781 |
| ARMISTICE CAPITAL, LLC | 4.9% | 1,536,000 | -6.1% | 0.67% | $27,340,800 |
| VANGUARD GROUP INC | 4.4% | 1,365,847 | +24% | 0% | $24,312,077 |
| FRANKLIN RESOURCES INC | 3.6% | 1,119,578 | -3.7% | 0% | $19,928,488 |
| Vivo Capital, LLC | 3.3% | 1,035,551 | 1.2% | $18,432,808 | |
| 72 Investment Holdings, LLC | 2.1% | 667,778 | 0% | 24% | $11,886,448 |
| MILLENNIUM MANAGEMENT LLC | 2% | 629,985 | +100% | 0.01% | $11,213,733 |
| BlackRock, Inc. | 2% | 607,874 | +65% | 0% | $10,820,158 |
| Ikarian Capital, LLC | 1.7% | 515,000 | +368% | 1.2% | $9,167,001 |
| ALKEON CAPITAL MANAGEMENT LLC | 1.5% | 477,101 | 0% | 0.04% | $8,492,398 |
| NORTHERN TRUST CORP | 1.5% | 474,373 | +2.8% | 0% | $8,443,839 |
| Integral Health Asset Management, LLC | 1.2% | 375,000 | -6.2% | 0.34% | $6,675,000 |
| Driehaus Capital Management LLC | 1.1% | 336,762 | 0.04% | $5,994,364 | |
| GEODE CAPITAL MANAGEMENT, LLC | 0.92% | 287,435 | +21% | 0% | $5,118,477 |
| Peapod Lane Capital LLC | 0.82% | 253,992 | -9.9% | 3.8% | $4,521,058 |
| AWM Investment Company, Inc. | 0.72% | 225,000 | -20% | 0.39% | $4,005,000 |
| Spruce Street Capital LP | 0.72% | 222,844 | 0% | 1.3% | $3,966,623 |
| JANE STREET GROUP, LLC | 0.62% | 194,041 | +301% | 0% | $3,453,929 |
| MARSHALL WACE, LLP | 0.62% | 193,109 | -77% | 0% | $3,437,340 |
| TWO SIGMA ADVISERS, LP | 0.51% | 160,100 | +6.8% | 0.01% | $2,849,780 |
| GOLDMAN SACHS GROUP INC | 0.5% | 156,319 | +73% | 0% | $2,782,478 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 24,486,977 | $435,860,459 | +$135,656,607 | $17.80 | 95 |
| 2025 Q3 | 16,755,091 | $67,358,617 | -$1,672,072 | $4.02 | 74 |
| 2025 Q2 | 17,296,212 | $38,050,471 | -$7,942,231 | $2.20 | 78 |
| 2025 Q1 | 20,845,367 | $45,026,701 | -$4,167,716 | $2.16 | 83 |
| 2024 Q4 | 22,530,140 | $95,292,066 | -$45,543,045 | $4.23 | 77 |
| 2024 Q3 | 22,939,574 | $265,498,730 | +$37,026,413 | $11.44 | 75 |
| 2024 Q2 | 18,600,674 | $198,841,035 | +$25,849,471 | $10.69 | 58 |
| 2024 Q1 | 15,971,812 | $245,167,778 | +$245,167,778 | $15.35 | 52 |