| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 16.3% | +1.9% | $28,423,825 | +$850,785 | 1,145,660 | +3.1% | JANUS HENDERSON GROUP PLC | 30 Jun 2025 |
| COMMODORE CAPITAL LP | 7.2% | $15,445,000 | 500,000 | COMMODORE CAPITAL LP | 31 Dec 2024 | |||
| Vivo Opportunity Fund Holdings, L.P. | 6.4% | $27,550,801 | 454,184 | Vivo Opportunity Fund Holdings, L.P. | 30 Sep 2025 | |||
| PERCEPTIVE ADVISORS LLC | 6.3% | $13,735,208 | 444,649 | Perceptive Advisors LLC | 31 Mar 2025 | |||
| Adage Capital Management, L.P. | 5.58% | $24,005,770 | 395,743 | Adage Capital Management, L.P. | 30 Sep 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 2.9% | $6,376,530 | 206,427 | RA Capital Management, L.P. | 31 Mar 2025 | |||
| Sio Capital Management, LLC | 2.69% | -65.4% | $11,571,744 | -$19,506,679 | 190,764 | -62.8% | Sio Capital Management, LLC | 30 Sep 2025 |
| Point72 Asset Management, L.P. | 3% | $4,175,988 | 135,189 | Point72 Asset Management, L.P. | 31 Dec 2024 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 6,034,640 | $365,700,278 | +$48,443,326 | $60.66 | 62 |
| 2025 Q2 | 5,234,387 | $136,973,710 | -$2,453,899 | $26.11 | 46 |
| 2025 Q1 | 5,217,399 | $188,361,504 | +$11,625,261 | $36.07 | 34 |
| 2024 Q4 | 4,897,032 | $176,406,965 | +$167,324,812 | $36.02 | 31 |
| 2024 Q3 | 191,547 | $229,810 | -$6,160 | $1.17 | 6 |
| 2024 Q2 | 197,030 | $207,191 | -$19,280 | $1.05 | 5 |
| 2024 Q1 | 213,375 | $255,563 | -$27,190 | $1.2 | 7 |
| 2023 Q4 | 228,082 | $329,806 | +$48,212 | $1.43 | 7 |
| 2023 Q3 | 194,505 | $309,171 | +$309,171 | $1.6 | 5 |