| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 16% | +1.9% | $28,423,825 | +$850,785 | 1,145,660 | +3.1% | JANUS HENDERSON GROUP PLC | 30 Jun 2025 |
| COMMODORE CAPITAL LP | 7.2% | $15,445,000 | 500,000 | COMMODORE CAPITAL LP | 31 Dec 2024 | |||
| Vivo Opportunity Fund Holdings, L.P. | 6.4% | $27,550,801 | 454,184 | Vivo Opportunity Fund Holdings, L.P. | 30 Sep 2025 | |||
| PERCEPTIVE ADVISORS LLC | 6.3% | $13,735,208 | 444,649 | Perceptive Advisors LLC | 31 Mar 2025 | |||
| Adage Capital Management, L.P. | 5.6% | $24,005,770 | 395,743 | Adage Capital Management, L.P. | 30 Sep 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 2.9% | $6,376,530 | 206,427 | RA Capital Management, L.P. | 31 Mar 2025 | |||
| Sio Capital Management, LLC | 2.7% | -65% | $11,571,744 | -$19,506,679 | 190,764 | -63% | Sio Capital Management, LLC | 30 Sep 2025 |
| Point72 Asset Management, L.P. | 3% | $4,175,988 | 135,189 | Point72 Asset Management, L.P. | 31 Dec 2024 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 16% | 1,145,660 | 0% | 0.03% | $69,134,853 |
| Cormorant Asset Management, LP | 15% | 1,059,331 | 0% | 4.4% | $64,259,018 |
| Vivo Capital, LLC | 7.1% | 501,617 | +99% | 2.4% | $30,428,087 |
| Commodore Capital LP | 7% | 500,000 | 0% | 1.5% | $30,330,000 |
| PERCEPTIVE ADVISORS LLC | 6.3% | 449,290 | +6.8% | 0.8% | $27,253,931 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5.6% | 395,743 | +98% | 0.04% | $24,005,770 |
| BRAIDWELL LP | 4.3% | 303,685 | 0.55% | $18,421,532 | |
| BlackRock, Inc. | 3.3% | 234,118 | +12% | 0% | $14,201,598 |
| MORGAN STANLEY | 2.7% | 192,866 | +19% | 0% | $11,699,251 |
| Sio Capital Management, LLC | 2.7% | 190,764 | -63% | 2.9% | $11,571,744 |
| Balyasny Asset Management L.P. | 2.6% | 186,922 | 0.02% | $11,338,689 | |
| Point72 Asset Management, L.P. | 1.5% | 105,020 | -22% | 0.01% | $6,370,513 |
| ACUTA CAPITAL PARTNERS, LLC | 1.2% | 84,875 | +75% | 5.3% | $5,148,518 |
| MILLENNIUM MANAGEMENT LLC | 1.1% | 76,681 | -31% | 0% | $4,651,469 |
| Walleye Capital LLC | 1% | 72,754 | +36% | 0.04% | $4,413,258 |
| STATE STREET CORP | 0.96% | 68,388 | +177% | 0% | $4,148,416 |
| Schonfeld Strategic Advisors LLC | 0.94% | 66,606 | -3.5% | 0.03% | $4,040,317 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.82% | 57,899 | +0.66% | 0% | $3,512,152 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0.76% | 53,950 | 3.2% | $3,272,607 | |
| VANGUARD GROUP INC | 0.64% | 45,103 | +41% | 0% | $2,735,947 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0.4% | 28,308 | 0% | 0.11% | $1,717,163 |
| BOOTHBAY FUND MANAGEMENT, LLC | 0.4% | 28,119 | +47% | 0.04% | $1,705,699 |
| NORTHERN TRUST CORP | 0.38% | 27,213 | +6.2% | 0% | $1,650,741 |
| JANE STREET GROUP, LLC | 0.22% | 15,903 | 0% | $964,676 | |
| Ikarian Capital, LLC | 0.22% | 15,431 | -76% | 0.21% | $936,044 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 6,034,640 | $365,700,278 | +$48,443,326 | 6,066% | 62 |
| 2025 Q2 | 5,234,387 | $136,973,710 | -$2,453,899 | 2,611% | 46 |
| 2025 Q1 | 5,217,399 | $188,361,504 | +$11,625,261 | 3,607% | 34 |
| 2024 Q4 | 4,897,032 | $176,406,965 | +$167,324,812 | 3,602% | 31 |
| 2024 Q3 | 191,547 | $229,810 | -$6,160 | 117% | 6 |
| 2024 Q2 | 197,030 | $207,191 | -$19,280 | 105% | 5 |
| 2024 Q1 | 213,375 | $255,563 | -$27,190 | 120% | 7 |
| 2023 Q4 | 228,082 | $329,806 | +$48,212 | 142.93% | 7 |
| 2023 Q3 | 194,505 | $309,171 | +$309,171 | 160% | 5 |