| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 15% | +7.1% | $234,944,605 | +$58,553,941 | 5,970,638 | +33% | FMR LLC | 30 Sep 2025 |
| RA CAPITAL MANAGEMENT, L.P. | 9.5% | +6.7% | $152,155,944 | +$39,350,000 | 3,866,733 | +35% | RA Capital Management, L.P. | 30 Sep 2025 |
| WELLINGTON MANAGEMENT GROUP LLP | 6.5% | $101,431,000 | 2,577,662 | Wellington Management Group LLP | 30 Sep 2025 | |||
| Octagon Capital Advisors LP | 6.1% | -14% | $95,095,846 | +$12,060,775 | 2,416,667 | +15% | Octagon Capital Advisors LP | 30 Sep 2025 |
| Fairmount Funds Management LLC | 4.9% | -50% | $72,191,285 | -$64,524,950 | 2,139,635 | -47% | Fairmount Funds Management LLC | 21 Nov 2025 |
| Point72 Asset Management, L.P. | 5.3% | +16% | $44,225,769 | +$14,080,318 | 2,121,140 | +47% | Point72 Asset Management, L.P. | 11 Sep 2025 |
| Avidity Partners Management LP | 4.9% | -50% | $70,995,168 | -$43,010,234 | 2,104,184 | -38% | Avidity Partners Management LP | 17 Nov 2025 |
| BlackRock, Inc. | 5% | $34,803,328 | 1,600,153 | BlackRock, Inc. | 31 Mar 2025 | |||
| TCG Crossover GP II, LLC | 4.7% | $32,660,322 | 1,501,624 | TCG Crossover GP II, LLC | 31 Mar 2025 | |||
| BCLS Fund III Investments, LP | 3.1% | -55% | $51,780,350 | -$45,896,187 | 1,315,892 | -47% | BCLS Fund III Investments, LP | 30 Sep 2025 |
| Vestal Point Capital, LP | 3% | -70% | $46,433,000 | -$79,487,000 | 1,180,000 | -63% | Vestal Point Capital, LP | 30 Sep 2025 |
| Venrock Healthcare Capital Partners III, L.P. | 3.1% | $20,060,000 | 1,000,000 | Venrock Healthcare Capital Partners III, L.P. | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 14% | 5,970,638 | +31% | 0.01% | $234,944,606 |
| Fairmount Funds Management LLC | 7.6% | 3,307,191 | +22% | 12% | $130,137,966 |
| Avidity Partners Management LP | 7.3% | 3,204,184 | +84% | 29% | $126,084,640 |
| RA CAPITAL MANAGEMENT, L.P. | 6.6% | 2,866,733 | 0% | 1.4% | $112,805,944 |
| WELLINGTON MANAGEMENT GROUP LLP | 5.9% | 2,577,662 | +3367% | 0.02% | $101,430,999 |
| Octagon Capital Advisors LP | 5.5% | 2,416,667 | +3.2% | 15% | $95,095,846 |
| Point72 Asset Management, L.P. | 4.7% | 2,041,960 | +47% | 0.17% | $80,351,150 |
| TCG Crossover Management, LLC | 3.8% | 1,676,624 | +12% | 3.2% | $65,975,154 |
| VANGUARD GROUP INC | 3.8% | 1,642,198 | +14% | 0% | $64,620,492 |
| BlackRock, Inc. | 3.1% | 1,340,091 | -1.4% | 0% | $52,732,580 |
| Bain Capital Life Sciences Investors, LLC | 3% | 1,315,892 | -47% | 3.4% | $51,780,350 |
| Vestal Point Capital, LP | 2.7% | 1,180,000 | -63% | 2.1% | $46,433,000 |
| CITADEL ADVISORS LLC | 2.3% | 1,013,501 | +52% | 0.03% | $39,881,264 |
| VR ADVISER, LLC | 2.2% | 960,803 | -3.9% | 2.1% | $37,807,598 |
| ALLIANCEBERNSTEIN L.P. | 2% | 852,384 | -27% | 0.01% | $33,541,310 |
| BRAIDWELL LP | 1.9% | 835,057 | 0.97% | $32,859,493 | |
| BAKER BROS. ADVISORS LP | 1.8% | 789,759 | 0% | 0.22% | $31,077,017 |
| Polar Capital Holdings Plc | 1.7% | 748,003 | 0.14% | $29,433,918 | |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1.5% | 674,966 | +605% | 3.8% | $26,559,912 |
| STATE STREET CORP | 1.5% | 671,048 | -18% | 0% | $26,405,739 |
| Catalio Capital Management, LP | 1.5% | 667,615 | -11% | 4.9% | $26,270,650 |
| Sio Capital Management, LLC | 1.3% | 577,750 | +145% | 5.8% | $22,734,463 |
| MARSHALL WACE, LLP | 1.3% | 572,938 | 0.02% | $22,545,109 | |
| GEODE CAPITAL MANAGEMENT, LLC | 1.2% | 536,415 | +11% | 0% | $21,113,062 |
| FRANKLIN RESOURCES INC | 1% | 450,311 | 0% | $17,719,737 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 18,799 | $774,643 | +$766,607 | $41.21 | 2 |
| 2025 Q3 | 46,828,772 | $1,842,663,442 | +$358,133,968 | $39.35 | 140 |
| 2025 Q2 | 39,106,709 | $728,558,630 | +$24,440,177 | $18.63 | 101 |
| 2025 Q1 | 37,715,319 | $685,461,303 | +$43,246,773 | $18.14 | 97 |
| 2024 Q4 | 35,126,689 | $765,706,199 | +$63,092,353 | $21.80 | 94 |
| 2024 Q3 | 31,364,805 | $858,714,506 | +$44,837,092 | $27.38 | 90 |
| 2024 Q2 | 29,702,499 | $768,778,734 | +$87,583,327 | $25.88 | 74 |
| 2024 Q1 | 26,075,021 | $782,250,559 | +$479,966,613 | $30.00 | 75 |
| 2023 Q4 | 10,291,119 | $106,507,945 | +$518,588 | $10.40 | 38 |
| 2023 Q3 | 10,072,640 | $136,328,208 | +$136,328,208 | $13.67 | 30 |