Fulcrum Therapeutics, Inc. - Common Stock, $0.001 par value per share (FULC) Institutional Ownership

13F Institutional Holders and Ownership History from Q3 2019 to Q4 2025

Type / Class
Equity / Common Stock, $0.001 par value per share
Symbol
FULC on Nasdaq
Shares outstanding
54,053,214
Price per share
$11.31
All holders as of 30 Sep 2025
Q3 2025
Total 13F shares
53,790,468
Total reported value
$494,909,996
% of total 13F portfolios
0%
Share change
-613,451
Value change
-$1,273,496
Number of holders
127
Price from insider filings
$11.31
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Fulcrum Therapeutics, Inc. - Common Stock, $0.001 par value per share (FULC) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
RA CAPITAL MANAGEMENT, L.P. 11% $55,938,590 6,053,960 RA Capital Management, L.P. 08 Dec 2025
SUVRETTA CAPITAL MANAGEMENT, LLC 9.4% +52% $18,495,988 +$6,069,154 5,067,394 +49% SUVRETTA CAPITAL MANAGEMENT, LLC 31 Mar 2025
Nantahala Capital Management, LLC 7.7% $17,439,379 4,777,912 Nantahala Capital Management, LLC 30 Sep 2024
BlackRock, Inc. 6% -19% $30,090,560 -$7,016,336 3,270,322 -19% BlackRock, Inc. 30 Sep 2025
Adage Capital Management, L.P. 4.5% -44% $22,374,400 -$19,844,400 2,432,000 -47% Adage Capital Management, L.P. 30 Sep 2025

As of 30 Sep 2025, 127 institutional investors reported holding 53,790,468 shares of Fulcrum Therapeutics, Inc. - Common Stock, $0.001 par value per share (FULC). This represents 100% of the company’s total 54,053,214 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of Fulcrum Therapeutics, Inc. - Common Stock, $0.001 par value per share (FULC) together control 90% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
RA CAPITAL MANAGEMENT, L.P. 19% 10,229,099 0% 1.2% $94,107,711
SUVRETTA CAPITAL MANAGEMENT, LLC 10% 5,381,000 +5.9% 1.5% $49,505,200
TCG Crossover Management, LLC 9.7% 5,250,000 0% 2.4% $48,300,000
Nantahala Capital Management, LLC 8.6% 4,670,784 +8.9% 2.7% $42,971,213
BlackRock, Inc. 6.9% 3,706,750 -15% 0% $34,102,100
VANGUARD GROUP INC 5.5% 2,999,464 -4.7% 0% $27,595,069
ADAGE CAPITAL PARTNERS GP, L.L.C. 4.5% 2,432,000 -47% 0.04% $22,374,400
Balyasny Asset Management L.P. 2.7% 1,450,480 +8.4% 0.03% $13,344,416
D. E. Shaw & Co., Inc. 2.7% 1,449,423 +23% 0.01% $13,334,692
DIMENSIONAL FUND ADVISORS LP 2.4% 1,299,308 -5.3% 0% $11,950,806
Ikarian Capital, LLC 2.4% 1,289,225 +201% 2.7% $11,860,870
STATE STREET CORP 2% 1,063,207 -13% 0% $9,781,504
GEODE CAPITAL MANAGEMENT, LLC 1.9% 1,004,051 -16% 0% $9,239,481
ROYAL BANK OF CANADA 1.9% 1,000,797 +23661% 0% $9,208,000
CITADEL ADVISORS LLC 1.6% 854,556 +414% 0.01% $7,861,915
BOOTHBAY FUND MANAGEMENT, LLC 1.3% 678,414 +380% 0.16% $6,241,409
GOLDMAN SACHS GROUP INC 1.1% 586,351 -49% 0% $5,394,429
NORTHERN TRUST CORP 1.1% 568,322 -7.1% 0% $5,228,563
ACADIAN ASSET MANAGEMENT LLC 1% 540,641 -4% 0.01% $4,971,000
Connor, Clark & Lunn Investment Management Ltd. 0.71% 384,138 +12% 0.01% $3,534,070
Schonfeld Strategic Advisors LLC 0.68% 366,303 +79% 0.02% $3,369,984
ADAR1 Capital Management, LLC 0.63% 341,612 +540% 0.31% $3,142,830
CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.62% 333,483 -14% 0% $3,068,044
JANE STREET GROUP, LLC 0.59% 321,520 +1745% 0% $2,957,984
UBS Group AG 0.56% 301,157 +123% 0% $2,770,645

Institutional Holders of Fulcrum Therapeutics, Inc. - Common Stock, $0.001 par value per share (FULC) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 1,301,507 $14,719,972 +$12,749,112 $11.31 10
2025 Q3 53,790,468 $494,909,996 -$1,273,496 $9.20 127
2025 Q2 54,400,644 $374,498,177 +$23,533,452 $6.88 122
2025 Q1 51,307,184 $147,764,693 -$3,070,431 $2.88 115
2024 Q4 51,666,381 $242,831,448 -$8,308,464 $4.70 117
2024 Q3 54,857,560 $195,845,950 -$86,380,213 $3.57 127
2024 Q2 64,752,304 $401,470,762 +$19,716,085 $6.20 120
2024 Q1 60,342,845 $569,639,654 -$2,974,963 $9.44 122
2023 Q4 61,083,723 $412,326,970 +$14,153,071 $6.75 100
2023 Q3 56,394,454 $250,394,156 +$9,019,379 $4.44 79
2023 Q2 55,518,138 $183,197,485 -$14,257,183 $3.30 85
2023 Q1 60,413,854 $172,155,022 +$51,602 $2.85 115
2022 Q4 50,644,890 $368,693,025 -$13,010,376 $7.28 109
2022 Q3 52,209,184 $422,360,458 +$98,764,326 $8.09 104
2022 Q2 40,127,745 $196,621,873 -$32,729,118 $4.90 97
2022 Q1 39,071,704 $923,864,555 +$64,674,079 $23.65 104
2021 Q4 37,197,291 $657,236,909 -$42,835,792 $17.69 107
2021 Q3 36,552,286 $1,031,536,477 +$305,128,643 $28.21 100
2021 Q2 26,798,436 $280,833,000 -$3,275,840 $10.48 66
2021 Q1 26,913,060 $317,031,000 +$45,552,581 $11.78 68
2020 Q4 22,170,825 $259,615,000 +$20,231,071 $11.71 65
2020 Q3 20,593,739 $163,306,000 -$36,882,837 $7.93 53
2020 Q2 20,455,938 $373,550,782 +$66,390,720 $18.29 60
2020 Q1 16,827,383 $200,921,119 +$11,941,010 $11.94 46
2019 Q4 15,784,835 $262,061,000 +$1,373,802 $16.64 38
2019 Q3 15,905,791 $105,135,052 +$105,135,052 $6.64 39