Tyra Biosciences, Inc. - Common Stock, par value $0.0001 per share (TYRA) Institutional Ownership

13F Institutional Holders and Ownership History from Q3 2021 to Q4 2025

Type / Class
Equity / Common Stock, par value $0.0001 per share
Symbol
TYRA on Nasdaq
Shares outstanding
53,888,889
Price per share
$26.29
All holders as of 30 Sep 2025
Q3 2025
Total 13F shares
55,638,635
Total reported value
$778,399,313
% of total 13F portfolios
0%
Share change
-1,109,943
Value change
-$9,877,531
Number of holders
115
Price from insider filings
$26.29
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Tyra Biosciences, Inc. - Common Stock, par value $0.0001 per share (TYRA) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
RA CAPITAL MANAGEMENT, L.P. 22% +12% $118,759,884 +$12,124,682 11,899,788 +11% RA Capital Management, L.P. 04 Jun 2025
BIOTECHNOLOGY VALUE FUND L P 7.8% $40,546,314 3,944,194 BVF PARTNERS L P/IL 31 Dec 2024
Canaan XI L.P. 7.4% $38,356,376 3,731,165 Canaan XI L.P. 31 Dec 2024
Commodore Capital LP 6.3% +22% $47,216,250 +$8,743,750 3,375,000 +23% Commodore Capital LP 30 Sep 2025
TCG Crossover GP I, LLC 5.7% $29,792,499 2,898,103 TCG Crossover GP I, LLC 27 Feb 2025
JANUS HENDERSON GROUP PLC 5.4% +6% $29,305,535 +$1,672,924 2,856,290 +6.1% JANUS HENDERSON GROUP PLC 30 Jun 2025
Vestal Point Capital, LP 4.5% -18% $33,925,750 -$6,363,058 2,425,000 -16% Vestal Point Capital, LP 30 Sep 2025
FMR LLC 3.2% $17,549,481 1,707,148 FMR LLC 31 Mar 2025

As of 30 Sep 2025, 115 institutional investors reported holding 55,638,635 shares of Tyra Biosciences, Inc. - Common Stock, par value $0.0001 per share (TYRA). This represents 103% of the company’s total 53,888,889 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of Tyra Biosciences, Inc. - Common Stock, par value $0.0001 per share (TYRA) together control 97% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
RA CAPITAL MANAGEMENT, L.P. 23% 12,198,625 0% 2.1% $170,658,764
Alta Partners Management Company, L.P. 7.6% 4,080,296 0% 95% $57,083,341
Nextech Invest, Ltd. 7.5% 4,055,861 0% 8.6% $56,741,495
BVF INC/IL 6.8% 3,649,794 -7.5% 2.1% $51,060,618
Canaan Partners XI LLC 6.7% 3,608,109 0% 49% $50,477,445
Commodore Capital LP 6.3% 3,375,000 +8.9% 2.3% $47,216,250
TCG Crossover Management, LLC 5.4% 2,898,103 0% 2% $40,544,461
JANUS HENDERSON GROUP PLC 5.3% 2,874,804 +0.65% 0.02% $40,232,882
Vestal Point Capital, LP 4.5% 2,425,000 -8.7% 1.5% $33,925,750
Kynam Capital Management, LP 4.3% 2,329,998 0% 2.4% $32,596,672
BlackRock, Inc. 3.5% 1,869,474 -1.3% 0% $26,153,941
VANGUARD GROUP INC 2.8% 1,520,185 +8.5% 0% $21,267,388
FARALLON CAPITAL MANAGEMENT LLC 2.1% 1,143,818 0% 0.09% $16,002,014
5AM Venture Management, LLC 1.7% 939,298 0% 4.8% $13,140,779
Balyasny Asset Management L.P. 1.6% 846,585 +45% 0.02% $11,843,724
Caligan Partners LP 1.3% 696,825 +267% 1.4% $9,748,582
MARSHALL WACE, LLP 1.1% 602,015 +41% 0.01% $8,422,190
GEODE CAPITAL MANAGEMENT, LLC 1.1% 597,454 +5.3% 0% $8,359,761
Sio Capital Management, LLC 0.96% 514,947 -36% 1.8% $7,204,109
STATE STREET CORP 0.8% 428,472 +2.3% 0% $5,994,323
MORGAN STANLEY 0.6% 322,143 -15% 0% $4,506,781
Walleye Capital LLC 0.55% 297,808 -20% 0.03% $4,166,334
Point72 Asset Management, L.P. 0.52% 282,032 +26% 0.01% $3,945,629
Eversept Partners, LP 0.51% 272,706 0.29% $3,815,157
JACOBS LEVY EQUITY MANAGEMENT, INC 0.47% 251,562 -36% 0.01% $3,519,352

Institutional Holders of Tyra Biosciences, Inc. - Common Stock, par value $0.0001 per share (TYRA) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 3,846,007 $101,111,525 -$6,881,906 $26.29 7
2025 Q3 55,638,635 $778,399,313 -$9,877,531 $13.99 115
2025 Q2 56,588,644 $541,513,140 +$28,813,504 $9.57 120
2025 Q1 53,573,458 $499,522,930 +$34,676,031 $9.30 116
2024 Q4 48,613,623 $675,760,666 -$145,254,713 $13.90 112
2024 Q3 47,054,295 $1,105,994,170 +$8,152,750 $23.51 94
2024 Q2 46,814,701 $748,570,507 -$1,810,347 $15.99 76
2024 Q1 46,852,011 $768,372,899 +$182,484,246 $16.40 75
2023 Q4 35,756,693 $495,188,385 -$9,797,725 $13.85 62
2023 Q3 36,462,633 $502,118,395 +$3,284,853 $13.77 59
2023 Q2 36,210,809 $616,671,033 +$8,028,494 $17.03 59
2023 Q1 35,654,296 $572,964,060 +$8,455,742 $16.07 50
2022 Q4 35,239,863 $267,821,738 -$5,207,345 $7.60 45
2022 Q3 35,692,923 $313,754,295 -$403,922 $8.79 43
2022 Q2 35,744,229 $255,572,000 -$3,322,156 $7.15 44
2022 Q1 36,133,976 $386,624,000 -$8,627,515 $10.70 46
2021 Q4 35,174,367 $494,157,000 +$13,654,547 $14.07 45
2021 Q3 26,080,552 $456,755,000 +$456,755,000 $17.59 25