| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 29% | $26,531,674 | 20,099,753 | RA Capital Management, L.P. | 26 Sep 2025 | |||
| Oxford Science Enterprises plc | 7.2% | $5,946,466 | 4,955,388 | Oxford Science Enterprises plc | 30 Sep 2025 | |||
| VIKING GLOBAL INVESTORS LP | 5.1% | $4,178,921 | 3,482,434 | VIKING GLOBAL INVESTORS LP | 26 Sep 2025 | |||
| Point72 Asset Management, L.P. | 3% | -65% | $9,551,949 | -$2,811,415 | 2,067,432 | -23% | Point72 Asset Management, L.P. | 30 Sep 2025 |
| JANUS HENDERSON GROUP PLC | 1.6% | $835,610 | 522,256 | JANUS HENDERSON GROUP PLC | 31 Dec 2024 | |||
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0.9% | -84% | $354,000 | -$1,605,900 | 300,000 | -82% | SUVRETTA CAPITAL MANAGEMENT, LLC | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 29% | 20,064,545 | +88% | 1.1% | $92,698,198 |
| VIKING GLOBAL INVESTORS LP | 5.1% | 3,482,434 | +135% | 0.04% | $16,088,845 |
| Commodore Capital LP | 3.4% | 2,357,319 | 0.53% | $10,890,814 | |
| Vivo Capital, LLC | 3.4% | 2,325,000 | 0.86% | $10,741,500 | |
| Point72 Asset Management, L.P. | 2.9% | 2,030,000 | -26% | 0.02% | $9,378,601 |
| BVF INC/IL | 2.8% | 1,915,000 | 0.36% | $8,847,300 | |
| Laurion Capital Management LP | 2.7% | 1,892,156 | +133% | 1.2% | $8,741,761 |
| VANGUARD GROUP INC | 2.6% | 1,768,356 | +89% | 0% | $8,169,805 |
| RTW INVESTMENTS, LP | 2.2% | 1,500,000 | 0.09% | $6,930,000 | |
| JANUS HENDERSON GROUP PLC | 2.2% | 1,500,000 | 0% | $6,915,000 | |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2.1% | 1,450,000 | +7.4% | 0.01% | $6,699,000 |
| Balyasny Asset Management L.P. | 1.9% | 1,333,583 | 0.01% | $6,161,153 | |
| Woodline Partners LP | 1.9% | 1,311,021 | +90% | 0.03% | $6,056,917 |
| Deep Track Capital, LP | 1.7% | 1,200,000 | 0.15% | $5,544,000 | |
| TCG Crossover Management, LLC | 1.7% | 1,200,000 | 0.27% | $5,544,000 | |
| AWM Investment Company, Inc. | 1.5% | 1,025,000 | 0.44% | $4,735,500 | |
| PERCEPTIVE ADVISORS LLC | 1.2% | 829,870 | 0.11% | $3,833,999 | |
| EcoR1 Capital, LLC | 1.2% | 800,000 | 0.18% | $3,696,000 | |
| Logos Global Management LP | 1.1% | 750,000 | 0.34% | $3,465,000 | |
| Siren, L.L.C. | 1% | 700,000 | 0.13% | $3,234,000 | |
| Octagon Capital Advisors LP | 1% | 700,000 | 0.5% | $3,234,000 | |
| MORGAN STANLEY | 0.83% | 575,156 | +787% | 0% | $2,657,221 |
| Ikarian Capital, LLC | 0.78% | 535,967 | +257% | 0.56% | $2,476,168 |
| MILLENNIUM MANAGEMENT LLC | 0.73% | 500,266 | -67% | 0% | $2,311,229 |
| Pictet Asset Management Holding SA | 0.7% | 481,365 | 0% | $2,223,906 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 56,737,328 | $262,111,695 | +$157,693,674 | 462% | 73 |
| 2025 Q2 | 23,229,340 | $25,784,572 | -$2,452,068 | 111% | 52 |
| 2025 Q1 | 25,317,246 | $35,570,823 | -$12,653,188 | 140.5% | 70 |
| 2024 Q4 | 24,998,818 | $94,745,310 | -$7,015,123 | 379% | 60 |
| 2024 Q3 | 25,334,214 | $216,644,659 | -$12,390,754 | 855% | 61 |
| 2024 Q2 | 25,149,149 | $401,355,577 | +$7,449,548 | 1,596% | 60 |
| 2024 Q1 | 24,686,276 | $362,963,150 | +$128,420,824 | 1,470% | 55 |
| 2023 Q4 | 16,202,612 | $110,201,548 | -$2,798,065 | 680% | 42 |
| 2023 Q3 | 16,622,352 | $84,440,903 | -$4,281,480 | 508% | 42 |
| 2023 Q2 | 17,094,762 | $153,705,578 | -$6,832 | 894% | 44 |
| 2023 Q1 | 17,170,175 | $209,991,326 | +$1,642,851 | 1,223% | 44 |
| 2022 Q4 | 17,012,848 | $227,459,628 | +$7,279,864 | 1,337% | 44 |
| 2022 Q3 | 16,727,993 | $151,914,000 | -$1,096,941 | 907.94% | 40 |
| 2022 Q2 | 16,841,628 | $167,235,000 | +$167,235,000 | 992.97% | 40 |