| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 8.9% | $361M | 5.6M | Baker Bros. Advisors LP | 31 Mar 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 8.7% | $482M | 5.56M | RA Capital Management, L.P. | 30 Jun 2025 | |||
| VANGUARD GROUP INC | 7.52% | $505M | 5M | The Vanguard Group | 30 Sep 2025 | |||
| PERCEPTIVE ADVISORS LLC | 6.8% | $285M | 4.42M | Perceptive Advisors LLC | 31 Mar 2025 | |||
| BlackRock, Inc. | 6.9% | $281M | 4.36M | BlackRock, Inc. | 31 Mar 2025 | |||
| PRIMECAP MANAGEMENT CO/CA/ | 6.42% | -15.6% | $431M | -$62.1M | 4.26M | -12.6% | PRIMECAP MANAGEMENT CO/CA/ | 30 Sep 2025 |
| GOLDMAN SACHS GROUP INC | 3% | $117M | 1.82M | THE GOLDMAN SACHS GROUP, INC. | 31 Dec 2024 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 70.9M | $7.16B | +$449M | $100.99 | 262 |
| 2025 Q2 | 66.5M | $4.2B | +$137M | $63.19 | 225 |
| 2025 Q1 | 64.6M | $3.42B | -$18.8M | $52.97 | 226 |
| 2024 Q4 | 64.9M | $3.63B | -$159M | $55.98 | 202 |
| 2024 Q3 | 67.7M | $3.55B | -$85.9M | $52.39 | 175 |
| 2024 Q2 | 69.3M | $2.85B | +$52.8M | $41.06 | 164 |
| 2024 Q1 | 68M | $2.95B | +$55.4M | $43.33 | 166 |
| 2023 Q4 | 66.7M | $3.07B | -$41.8M | $45.97 | 167 |
| 2023 Q3 | 68.1M | $1.56B | +$58.5M | $22.93 | 143 |
| 2023 Q2 | 66.2M | $1.09B | +$94.1M | $16.49 | 116 |
| 2023 Q1 | 60.3M | $1.08B | -$49.1M | $17.84 | 125 |
| 2022 Q4 | 62.4M | $1.82B | +$85.6M | $29.12 | 116 |
| 2022 Q3 | 59.5M | $1.45B | +$426M | $24.50 | 99 |
| 2022 Q2 | 45.9M | $191M | -$18.8M | $4.15 | 82 |
| 2022 Q1 | 48.8M | $563M | +$4.69M | $11.52 | 105 |
| 2021 Q4 | 48.4M | $484M | -$538K | $9.98 | 94 |
| 2021 Q3 | 48M | $626M | +$2.43M | $13.06 | 93 |
| 2021 Q2 | 42.6M | $835M | -$3.43M | $19.58 | 101 |
| 2021 Q1 | 47.6M | $1.01B | +$147M | $21.27 | 119 |
| 2020 Q4 | 40.5M | $1.2B | +$39.5M | $29.73 | 114 |
| 2020 Q3 | 39.2M | $851M | -$43.7M | $21.67 | 114 |
| 2020 Q2 | 41.2M | $920M | +$12M | $22.30 | 89 |
| 2020 Q1 | 40.8M | $621M | -$34.2M | $15.22 | 80 |
| 2019 Q4 | 42.4M | $973M | +$189M | $22.96 | 89 |
| 2019 Q3 | 34.3M | $741M | +$64.8M | $21.59 | 84 |
| 2019 Q2 | 31.3M | $688M | +$9.1M | $22.00 | 83 |
| 2019 Q1 | 30.9M | $846M | -$21.9M | $27.41 | 85 |
| 2018 Q4 | 31.7M | $851M | +$12.8M | $26.88 | 73 |
| 2018 Q3 | 31.1M | $908M | +$2.06M | $29.17 | 77 |
| 2018 Q2 | 31M | $970M | +$216M | $31.26 | 84 |
| 2018 Q1 | 24.4M | $406M | -$5.86M | $19.90 | 54 |
| 2017 Q4 | 21.6M | $628M | +$507M | $29.06 | 65 |