RHYTHM PHARMACEUTICALS, INC. - COM (RYTM)

Historical Holders from Q4 2017 to Q3 2025

Symbol: RYTM on Nasdaq
Type / Class: Equity / COM
Shares outstanding: 66,399,673
All holders as of 30 Sep 2025: Q3 2025
Total 13F shares, excl. options: 70,889,646
Holdings value: $7,159,045,368
% of all portfolios: 0.01%
Number of holders: 262
Number of buys: 153
Number of sells: -98
Average buys %: +0%
Average sells %: -0%

Reported Shares, Excluding Options vs Price

Reported Value, Excluding Options

Total Investors

Significant Owners of RHYTHM PHARMACEUTICALS, INC. - COM (RYTM)

Filer	Ownership	Change %	Holdings Value	Net Change	Nb Shares	Change %	Reporting Name	Report Period
BAKER BROS. ADVISORS LP	8.9%		$360,984,750		5,604,483		Baker Bros. Advisors LP	31 Mar 2025
RA CAPITAL MANAGEMENT, L.P.	8.7%		$482,169,825		5,561,359		RA Capital Management, L.P.	30 Jun 2025
VANGUARD GROUP INC	7.52%		$504,589,163		4,996,427		The Vanguard Group	30 Sep 2025
PERCEPTIVE ADVISORS LLC	6.8%		$284,913,835		4,423,441		Perceptive Advisors LLC	31 Mar 2025
BlackRock, Inc.	6.9%		$281,130,327		4,364,700		BlackRock, Inc.	31 Mar 2025
PRIMECAP MANAGEMENT CO/CA/	6.42%	-15.6%	$430,506,130	-$62,126,826	4,262,859	-12.6%	PRIMECAP MANAGEMENT CO/CA/	30 Sep 2025
GOLDMAN SACHS GROUP INC	3%		$117,157,406		1,818,931		THE GOLDMAN SACHS GROUP, INC.	31 Dec 2024

Institutional Holders of RHYTHM PHARMACEUTICALS, INC. - COM (RYTM)

Period	Reported Shares, Excl. Options	Value, Excl. Options	Change	Puts Notional Value	Calls Notional Value	Price	Investors
2025 Q3	70,889,646	$7,159,045,368	+$449,473,140	$15,138,401	$50,232,426	$100.99	262
2025 Q2	66,543,505	$4,204,958,379	+$136,584,141	$36,302,655	$13,269,900	$63.19	225
2025 Q1	64,595,384	$3,424,910,613	-$18,829,096	$3,326,516	$20,833,101	$52.97	226
2024 Q4	64,917,500	$3,634,217,578	-$158,677,402	$1,489,068	$24,883,110	$55.98	202
2024 Q3	67,700,036	$3,546,202,706	-$85,917,668	$4,117,854	$42,624,504	$52.39	175
2024 Q2	69,300,680	$2,846,175,742	+$52,795,226	$9,176,910	$14,650,272	$41.06	164
2024 Q1	68,030,458	$2,946,208,413	+$55,358,404	$3,644,053	$38,139,418	$43.33	166
2023 Q4	66,696,112	$3,065,811,725	-$41,849,707	$2,123,814	$38,071,922	$45.97	167
2023 Q3	68,143,293	$1,562,080,292	+$58,456,223	$1,150,880	$5,329,933	$22.92	143
2023 Q2	66,212,640	$1,092,127,229	+$94,106,398	$150,059	$832,745	$16.49	116
2023 Q1	60,335,883	$1,076,382,910	-$49,077,961	$3,020,312	$9,940,248	$17.84	125
2022 Q4	62,378,764	$1,816,485,551	+$85,568,575	$9,714,432	$12,250,784	$29.12	116
2022 Q3	59,549,165	$1,446,896,472	+$426,232,319	$10,831,000	$24,765,000	$24.5	99
2022 Q2	45,934,145	$190,627,988	-$18,795,957	$0	$1,354,000	$4.15	82
2022 Q1	48,841,709	$562,605,977	+$4,688,818	$181,000	$3,454,000	$11.52	105
2021 Q4	48,449,400	$483,522,595	-$537,879		$112,000	$9.98	94
2021 Q3	47,950,622	$626,233,206	+$2,428,146	$0	$688,000	$13.06	93
2021 Q2	42,614,232	$834,516,313	-$3,429,160	$565,000	$0	$19.58	101
2021 Q1	47,577,014	$1,011,965,096	+$147,271,703	$1,143,000	$572,000	$21.27	119
2020 Q4	40,510,233	$1,201,291,923	+$39,479,834	$4,969,000	$2,525,000	$29.73	114
2020 Q3	39,249,591	$850,611,960	-$43,710,727	$1,835,000	$647,000	$21.67	114
2020 Q2	41,237,373	$919,577,883	+$11,957,883			$22.3	89
2020 Q1	40,805,984	$621,064,603	-$34,159,931			$15.22	80
2019 Q4	42,379,694	$973,032,101	+$189,224,828		$0	$22.96	89
2019 Q3	34,304,970	$740,632,813	+$64,825,672		$214,000	$21.59	84
2019 Q2	31,264,637	$687,757,946	+$9,100,651			$22	83
2019 Q1	30,865,613	$846,116,903	-$21,936,591			$27.41	85
2018 Q4	31,656,641	$850,986,460	+$12,828,367			$26.88	73
2018 Q3	31,142,295	$908,421,537	+$2,062,008			$29.17	77
2018 Q2	31,030,594	$970,020,757	+$215,509,581			$31.26	84
2018 Q1	24,362,024	$405,654,613	-$5,856,715			$19.9	54
2017 Q4	21,624,878	$628,421,658	+$507,347,658			$29.06	65