| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 8.4% | $144M | 17.5M | BlackRock, Inc. | 31 Mar 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 7.3% | $116M | 15.3M | RA Capital Management, L.P. | 04 Nov 2025 | |||
| Flynn James E | 5.8% | $103M | 12.2M | Deerfield Mgmt, L.P. | 12 Sep 2025 | |||
| Avoro Capital Advisors LLC | 4.2% | $71.5M | 8.7M | Avoro Capital Advisors LLC | 31 Mar 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 194M | $1.47B | -$36.1M | $7.59 | 280 |
| 2025 Q2 | 197M | $1.77B | +$203M | $8.96 | 292 |
| 2025 Q1 | 174M | $1.31B | +$63.4M | $7.50 | 273 |
| 2024 Q4 | 168M | $1.26B | -$40.4M | $7.52 | 256 |
| 2024 Q3 | 173M | $1.32B | -$13.5M | $7.60 | 255 |
| 2024 Q2 | 174M | $1.08B | -$26.2M | $6.18 | 238 |
| 2024 Q1 | 180M | $914M | +$14.5M | $5.08 | 235 |
| 2023 Q4 | 177M | $1.06B | -$13.9M | $5.99 | 234 |
| 2023 Q3 | 176M | $1.24B | +$20.8M | $7.08 | 229 |
| 2023 Q2 | 174M | $1.23B | +$15.8M | $7.04 | 233 |
| 2023 Q1 | 171M | $1.42B | +$99M | $8.34 | 237 |
| 2022 Q4 | 158M | $1.81B | +$89.1M | $11.48 | 225 |
| 2022 Q3 | 149M | $1.88B | -$39.5M | $12.60 | 218 |
| 2022 Q2 | 152M | $1.61B | +$202M | $10.58 | 207 |
| 2022 Q1 | 128M | $2.07B | +$162M | $16.26 | 219 |
| 2021 Q4 | 118M | $1.62B | +$189M | $13.85 | 197 |
| 2021 Q3 | 103M | $1.48B | -$23.7M | $14.37 | 191 |
| 2021 Q2 | 105M | $1.65B | +$25.6M | $15.81 | 190 |
| 2021 Q1 | 105M | $1.06B | -$142M | $10.17 | 183 |
| 2020 Q4 | 121M | $898M | -$43.6M | $7.45 | 172 |
| 2020 Q3 | 128M | $438M | -$23.5M | $3.44 | 150 |
| 2020 Q2 | 133M | $635M | +$96.6M | $4.76 | 160 |
| 2020 Q1 | 123M | $245M | -$37.9M | $2.00 | 127 |
| 2019 Q4 | 137M | $473M | +$126M | $3.45 | 131 |
| 2019 Q3 | 98.7M | $283M | -$6.97M | $2.87 | 110 |
| 2019 Q2 | 100M | $380M | -$87.9M | $3.79 | 112 |
| 2019 Q1 | 101M | $826M | +$1.49M | $8.14 | 129 |
| 2018 Q4 | 101M | $817M | +$8.89M | $8.07 | 118 |
| 2018 Q3 | 100M | $764M | +$73.7M | $7.63 | 110 |
| 2018 Q2 | 87.5M | $501M | -$8.81M | $5.73 | 98 |
| 2018 Q1 | 89.1M | $425M | -$6.63M | $4.77 | 98 |
| 2017 Q4 | 90.3M | $443M | +$30.2M | $4.91 | 111 |
| 2017 Q3 | 83.7M | $439M | +$76.3M | $5.24 | 118 |
| 2017 Q2 | 69.1M | $384M | +$3.63M | $5.56 | 112 |
| 2017 Q1 | 67.6M | $568M | +$140M | $8.40 | 114 |
| 2016 Q4 | 58.4M | $370M | +$11.8M | $6.33 | 107 |
| 2016 Q3 | 56.6M | $249M | +$23.4M | $4.41 | 98 |
| 2016 Q2 | 51.8M | $147M | -$10.6M | $2.84 | 91 |
| 2016 Q1 | 55.5M | $157M | -$57.9M | $2.83 | 103 |
| 2015 Q4 | 63M | $650M | -$21.2M | $10.32 | 116 |
| 2015 Q3 | 65M | $740M | +$18.2M | $11.40 | 123 |
| 2015 Q2 | 63M | $940M | -$26.3M | $14.93 | 121 |
| 2015 Q1 | 64.9M | $586M | +$36.7M | $9.03 | 96 |
| 2014 Q4 | 60.8M | $740M | +$22.5M | $12.16 | 90 |
| 2014 Q3 | 56.7M | $554M | +$30.6M | $9.78 | 101 |
| 2014 Q2 | 53.1M | $677M | +$131M | $12.75 | 100 |
| 2014 Q1 | 43.5M | $460M | +$93.2M | $10.58 | 86 |