| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 10% | +7.8% | $414,340,651 | +$32,457,883 | 13,132,826 | +8.5% | FMR LLC | 29 Aug 2025 |
| JANUS HENDERSON GROUP PLC | 10% | -12% | $472,013,392 | -$57,168,819 | 13,104,203 | -11% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | $426,531,754 | 12,964,491 | RA Capital Management, L.P. | 31 Mar 2025 | |||
| BlackRock, Inc. | 7.6% | $323,263,490 | 9,825,638 | BlackRock, Inc. | 31 Mar 2025 | |||
| T. Rowe Price Investment Management, Inc. | 6.4% | $299,523,446 | 8,315,476 | T. Rowe Price Investment Management, Inc. | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 10% | 13,104,203 | -11% | 0.22% | $472,046,873 |
| FMR LLC | 9.6% | 12,509,933 | +3% | 0.02% | $450,607,771 |
| VANGUARD GROUP INC | 9.5% | 12,320,453 | +2.7% | 0.01% | $443,782,718 |
| RA CAPITAL MANAGEMENT, L.P. | 9.2% | 11,965,991 | 0% | 5.3% | $431,014,996 |
| BlackRock, Inc. | 7.7% | 9,955,978 | -6.4% | 0.01% | $358,614,332 |
| T. Rowe Price Investment Management, Inc. | 6.4% | 8,315,295 | +39% | 0.18% | $299,517,000 |
| WELLINGTON MANAGEMENT GROUP LLP | 3.9% | 5,032,771 | +1.6% | 0.03% | $181,280,411 |
| STATE STREET CORP | 3.7% | 4,785,889 | -3.2% | 0.01% | $172,387,722 |
| D. E. Shaw & Co., Inc. | 3.3% | 4,290,790 | +39% | 0.12% | $154,554,256 |
| Paradigm Biocapital Advisors LP | 2.9% | 3,784,755 | +12% | 4% | $136,326,875 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 2.9% | 3,732,715 | +22% | 0.56% | $134,452,394 |
| Kynam Capital Management, LP | 2.4% | 3,071,588 | 0% | 8.2% | $110,638,600 |
| Deep Track Capital, LP | 2.3% | 3,000,000 | +40% | 3% | $108,060,000 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.2% | 2,884,040 | -4.2% | 0.01% | $103,898,128 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.3% | 1,688,483 | -47% | 0.01% | $60,820,000 |
| JPMORGAN CHASE & CO | 1.2% | 1,565,036 | +31% | 0% | $56,372,597 |
| Eversept Partners, LP | 1.1% | 1,421,983 | +9.5% | 3.9% | $51,219,828 |
| Pivotal bioVenture Partners Investment Advisor LLC | 1.1% | 1,372,425 | +5.2% | 29% | $49,434,749 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1% | 1,293,407 | -8.8% | 0.01% | $46,588,520 |
| MAVERICK CAPITAL LTD | 0.99% | 1,289,567 | -1.6% | 0.62% | $46,450,203 |
| JENNISON ASSOCIATES LLC | 0.9% | 1,170,899 | -16% | 0.02% | $42,175,782 |
| NORTHERN TRUST CORP | 0.83% | 1,073,346 | -4.3% | 0% | $38,661,924 |
| Pictet Asset Management Holding SA | 0.79% | 1,029,629 | -12% | 0.04% | $37,087,237 |
| GOLDMAN SACHS GROUP INC | 0.75% | 975,377 | +4.4% | 0.01% | $35,133,079 |
| ROYAL BANK OF CANADA | 0.73% | 949,049 | +27% | 0.01% | $34,184,000 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 11,440 | $527,842 | -$55,644 | $46.14 | 4 |
| 2025 Q3 | 141,274,894 | $5,088,535,411 | -$216,626,334 | $36.02 | 280 |
| 2025 Q2 | 147,479,114 | $4,794,596,759 | -$48,097,035 | $32.51 | 292 |
| 2025 Q1 | 133,025,604 | $5,021,104,716 | -$42,905,782 | $37.76 | 302 |
| 2024 Q4 | 140,784,610 | $11,525,526,197 | +$183,138,339 | $81.86 | 318 |
| 2024 Q3 | 136,507,040 | $15,592,116,896 | +$1,498,526,683 | $114.27 | 325 |
| 2024 Q2 | 122,578,572 | $9,264,040,265 | +$268,135,107 | $75.51 | 264 |
| 2024 Q1 | 119,065,967 | $8,130,427,051 | +$1,115,777,265 | $68.31 | 249 |
| 2023 Q4 | 103,087,407 | $6,473,142,685 | +$69,029,370 | $62.80 | 223 |
| 2023 Q3 | 101,381,209 | $5,166,522,410 | +$77,032,504 | $50.98 | 202 |
| 2023 Q2 | 99,996,517 | $4,993,540,992 | +$865,860,362 | $49.94 | 194 |
| 2023 Q1 | 84,121,058 | $3,152,798,116 | +$159,886,756 | $37.48 | 186 |
| 2022 Q4 | 81,609,487 | $3,913,093,743 | +$1,140,362,544 | $47.95 | 197 |
| 2022 Q3 | 56,496,728 | $1,356,264,990 | +$122,059,625 | $24.00 | 121 |
| 2022 Q2 | 51,432,581 | $1,119,137,255 | +$31,274,087 | $21.76 | 103 |
| 2022 Q1 | 49,852,918 | $1,203,855,921 | +$69,029,421 | $24.15 | 86 |
| 2021 Q4 | 44,718,114 | $1,063,493,543 | +$32,023,661 | $23.79 | 84 |
| 2021 Q3 | 43,198,231 | $1,095,966,337 | -$195,558 | $25.37 | 77 |
| 2021 Q2 | 43,222,434 | $972,744,067 | -$14,050,462 | $22.51 | 74 |
| 2021 Q1 | 44,022,105 | $869,193,186 | +$26,485,491 | $19.75 | 73 |
| 2020 Q4 | 42,260,768 | $1,118,933,017 | +$58,331,379 | $26.57 | 83 |
| 2020 Q3 | 37,761,937 | $1,857,382,730 | +$103,777,823 | $49.38 | 60 |
| 2020 Q2 | 35,950,832 | $1,126,753,000 | +$1,126,753,000 | $31.61 | 38 |