| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 17% | +48% | $866,626,126 | +$300,351,037 | 9,604,634 | +53% | T. Rowe Price Investment Management, Inc. | 30 Nov 2025 |
| FMR LLC | 10% | -9.2% | $473,004,163 | -$44,527,920 | 5,761,317 | -8.6% | FMR LLC | 30 Sep 2025 |
| Elghandour Rami | 6.9% | $258,654,412 | 3,997,132 | Rami Elghandour | 27 Feb 2025 | |||
| VANGUARD GROUP INC | 7.2% | +18% | $257,879,445 | +$42,389,191 | 3,985,156 | +20% | The Vanguard Group | 31 Mar 2025 |
| BlackRock, Inc. | 6.4% | $228,246,406 | 3,527,220 | BlackRock, Inc. | 31 Mar 2025 | |||
| New Enterprise Associates 15, L.P. | 5.5% | -18% | $200,278,848 | -$45,223,076 | 3,055,360 | -18% | Scott D. Sandell | 12 Aug 2025 |
| PERCEPTIVE ADVISORS LLC | 4.5% | -16% | $162,432,900 | -$29,397,733 | 2,478,000 | -15% | Perceptive Advisors LLC | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| GILEAD SCIENCES, INC. | 12% | 6,720,803 | 0% | 31% | $551,777,926 |
| T. Rowe Price Investment Management, Inc. | 11% | 6,352,356 | +227% | 0.32% | $521,529,000 |
| FMR LLC | 10% | 5,761,317 | -3.5% | 0.02% | $473,004,165 |
| Paradigm Biocapital Advisors LP | 8% | 4,649,016 | 0% | 11% | $381,684,214 |
| VANGUARD GROUP INC | 6.8% | 3,907,087 | -0.96% | 0% | $320,771,843 |
| BlackRock, Inc. | 5.9% | 3,387,896 | -2.3% | 0% | $278,146,282 |
| NEA Management Company, LLC | 5.3% | 3,045,262 | -19% | 14% | $250,016,010 |
| RA CAPITAL MANAGEMENT, L.P. | 5.2% | 3,036,527 | 0% | 3.1% | $249,298,867 |
| PERCEPTIVE ADVISORS LLC | 4.3% | 2,468,353 | -0.39% | 5.9% | $202,651,781 |
| SR One Capital Management, LP | 4.1% | 2,346,630 | 0% | 28% | $192,658,323 |
| STATE STREET CORP | 2.6% | 1,526,027 | -4.2% | 0% | $125,286,817 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.2% | 1,264,051 | -12% | 0.01% | $103,779,000 |
| Vestal Point Capital, LP | 2.2% | 1,250,000 | -55% | 4.7% | $102,625,000 |
| AJU IB Investment Co., Ltd. | 1.8% | 1,047,557 | 0% | 75% | $86,004,430 |
| CITADEL ADVISORS LLC | 1.8% | 1,021,453 | +415% | 0.07% | $83,861,291 |
| JANUS HENDERSON GROUP PLC | 1.8% | 1,013,921 | -0.94% | 0.04% | $83,246,424 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.6% | 926,304 | -3.7% | 0% | $76,063,242 |
| JPMORGAN CHASE & CO | 1.5% | 882,503 | -9.7% | 0% | $72,453,497 |
| Capital World Investors | 1.4% | 783,011 | 0% | 0.01% | $64,285,203 |
| Cormorant Asset Management, LP | 1.3% | 775,000 | -3.1% | 4.4% | $63,627,500 |
| BAMCO INC /NY/ | 0.95% | 550,236 | +6.2% | 0.12% | $45,174,376 |
| Schonfeld Strategic Advisors LLC | 0.86% | 500,315 | +44% | 0.29% | $41,075,859 |
| Affinity Asset Advisors, LLC | 0.86% | 500,000 | +1% | 3.8% | $41,050,000 |
| GOLDMAN SACHS GROUP INC | 0.78% | 448,441 | -12% | 0.01% | $36,817,006 |
| MORGAN STANLEY | 0.75% | 432,882 | -16% | 0% | $35,539,678 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 4,448 | $282,896 | +$239,929 | $65.20 | 5 |
| 2025 Q3 | 63,038,821 | $5,175,117,679 | +$190,810,895 | $82.10 | 206 |
| 2025 Q2 | 60,837,024 | $4,006,426,303 | -$46,745,437 | $65.85 | 200 |
| 2025 Q1 | 61,569,105 | $4,042,657,536 | +$146,759,811 | $65.60 | 195 |
| 2024 Q4 | 59,173,488 | $4,537,933,690 | +$127,885,655 | $76.69 | 208 |
| 2024 Q3 | 49,489,073 | $4,134,912,072 | -$113,389,722 | $83.51 | 185 |
| 2024 Q2 | 50,216,931 | $2,771,120,513 | +$171,282,810 | $55.19 | 164 |
| 2024 Q1 | 47,012,321 | $3,269,162,577 | +$35,796,177 | $69.55 | 180 |
| 2023 Q4 | 46,737,558 | $2,593,995,956 | -$29,980,183 | $55.50 | 154 |
| 2023 Q3 | 47,577,643 | $1,707,089,455 | -$7,341,800 | $35.88 | 132 |
| 2023 Q2 | 48,066,751 | $1,519,832,876 | +$79,444,997 | $31.62 | 134 |
| 2023 Q1 | 45,593,955 | $1,403,613,948 | +$114,227,065 | $30.81 | 115 |
| 2022 Q4 | 41,987,329 | $1,300,761,660 | +$53,764,127 | $30.98 | 123 |
| 2022 Q3 | 41,706,487 | $782,853,521 | +$127,574,774 | $18.77 | 74 |
| 2022 Q2 | 34,934,000 | $621,506,000 | +$145,615,758 | $18.08 | 67 |
| 2022 Q1 | 26,872,990 | $357,855,000 | +$357,824,000 | $14.02 | 48 |