| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Bellevue Group AG | 15.7% | $17,675,334 | 9,929,963 | Bellevue Group AG | 01 Jun 2025 | |||
| ARMISTICE CAPITAL, LLC | 9.98% | -0.1% | $11,269,840 | +$35,800 | 6,296,000 | +0.32% | Armistice Capital, LLC | 31 Mar 2025 |
| WASATCH ADVISORS LP | 3.1% | -41.7% | $3,276,482 | -$2,584,186 | 1,950,287 | -44.1% | Wasatch Advisors LP | 30 Sep 2025 |
| BlackRock, Inc. | 2.9% | $2,194,571 | 1,813,695 | BlackRock, Inc. | 30 Jun 2025 | |||
| MILLENNIUM MANAGEMENT LLC | 2.7% | $3,086,408 | 1,724,250 | Millennium Management LLC | 31 Mar 2025 | |||
| Frazier Life Sciences Public Fund, L.P. | 2.5% | $2,494,201 | 1,549,193 | Frazier Life Sciences Public Fund, L.P. | 30 Jun 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 45,995,618 | $77,272,120 | -$2,545,324 | $1.68 | 101 |
| 2025 Q2 | 48,254,634 | $58,417,269 | -$6,816,378 | $1.21 | 109 |
| 2025 Q1 | 53,787,262 | $68,275,226 | -$6,563,237 | $1.27 | 124 |
| 2024 Q4 | 56,086,649 | $182,277,562 | +$1,567,680 | $3.25 | 125 |
| 2024 Q3 | 54,902,225 | $180,609,672 | -$21,573,575 | $3.29 | 119 |
| 2024 Q2 | 60,780,167 | $258,313,062 | -$142,568,369 | $4.25 | 141 |
| 2024 Q1 | 64,754,082 | $953,179,892 | +$47,766,062 | $14.72 | 160 |
| 2023 Q4 | 61,853,452 | $595,031,063 | +$42,076,156 | $9.62 | 135 |
| 2023 Q3 | 58,037,496 | $270,452,676 | -$10,612,704 | $4.66 | 125 |
| 2023 Q2 | 60,016,268 | $321,083,284 | +$4,896,794 | $5.35 | 128 |
| 2023 Q1 | 58,447,529 | $419,062,824 | +$13,088,841 | $7.17 | 134 |
| 2022 Q4 | 56,759,894 | $380,843,944 | +$1,005,535 | $6.71 | 132 |
| 2022 Q3 | 57,575,517 | $199,204,006 | -$24,411,977 | $3.46 | 125 |
| 2022 Q2 | 62,614,291 | $184,903,988 | -$36,679,744 | $2.95 | 122 |
| 2022 Q1 | 60,299,794 | $531,229,517 | +$2,906,259 | $8.81 | 137 |
| 2021 Q4 | 57,195,769 | $918,067,066 | -$24,934,268 | $16.05 | 150 |
| 2021 Q3 | 57,874,256 | $1,211,800,601 | -$1,579,067 | $20.94 | 148 |
| 2021 Q2 | 57,205,089 | $1,536,547,929 | +$8,981,504 | $26.86 | 145 |
| 2021 Q1 | 56,061,432 | $1,785,526,852 | +$84,404,214 | $31.85 | 172 |
| 2020 Q4 | 53,782,589 | $1,229,394,378 | -$4,957,016 | $22.86 | 142 |
| 2020 Q3 | 53,058,543 | $1,336,560,085 | +$57,695,259 | $25.19 | 135 |
| 2020 Q2 | 50,654,768 | $1,414,302,624 | +$299,006,012 | $27.92 | 131 |
| 2020 Q1 | 44,072,517 | $256,481,821 | -$13,932,489 | $5.82 | 115 |
| 2019 Q4 | 45,488,459 | $494,902,348 | -$13,404,901 | $10.88 | 122 |
| 2019 Q3 | 46,464,006 | $592,867,161 | -$12,562,793 | $12.76 | 120 |
| 2019 Q2 | 46,896,511 | $795,717,581 | +$190,321,437 | $16.97 | 127 |
| 2019 Q1 | 43,999,290 | $791,052,372 | +$150,773,973 | $17.98 | 152 |
| 2018 Q4 | 36,788,060 | $467,188,625 | -$29,674,211 | $12.7 | 126 |
| 2018 Q3 | 36,789,217 | $788,932,455 | -$33,964,038 | $21.44 | 126 |
| 2018 Q2 | 38,444,053 | $793,879,768 | +$10,342,160 | $20.65 | 126 |
| 2018 Q1 | 37,720,122 | $948,936,306 | +$114,619,701 | $25.16 | 130 |
| 2017 Q4 | 33,636,592 | $638,496,847 | +$15,104,735 | $19 | 115 |
| 2017 Q3 | 31,580,541 | $583,134,305 | +$5,299,720 | $18.48 | 111 |
| 2017 Q2 | 31,326,219 | $548,559,268 | +$40,918,864 | $17.51 | 111 |
| 2017 Q1 | 28,885,755 | $537,331,176 | +$37,794,433 | $18.6 | 110 |
| 2016 Q4 | 29,059,096 | $593,934,489 | -$14,285,927 | $20.44 | 127 |
| 2016 Q3 | 28,232,393 | $844,416,283 | +$4,369,879 | $29.91 | 128 |
| 2016 Q2 | 28,121,396 | $758,990,766 | +$13,826,968 | $26.99 | 120 |
| 2016 Q1 | 27,896,098 | $522,962,644 | +$2,321,086 | $18.75 | 125 |
| 2015 Q4 | 27,649,274 | $856,321,717 | +$11,376,068 | $30.97 | 128 |
| 2015 Q3 | 27,323,666 | $585,251,686 | +$102,312,506 | $21.42 | 124 |
| 2015 Q2 | 21,893,468 | $831,287,412 | +$79,012,592 | $37.97 | 127 |
| 2015 Q1 | 19,955,304 | $626,454,002 | +$94,283,734 | $31.37 | 112 |
| 2014 Q4 | 16,815,059 | $589,710,584 | +$46,599,841 | $35.07 | 106 |
| 2014 Q3 | 15,402,521 | $321,915,508 | +$1,939,698 | $20.9 | 84 |
| 2014 Q2 | 15,292,805 | $332,310,989 | -$45,758,383 | $21.73 | 89 |
| 2014 Q1 | 14,275,251 | $397,192,815 | +$111,531,189 | $27.83 | 74 |