| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 44% | -12% | $249,200,088 | +$30,000,153 | 17,761,945 | +14% | SUVRETTA CAPITAL MANAGEMENT, LLC | 07 Nov 2025 |
| FRANKLIN RESOURCES INC | 15% | -8.8% | $58,140,839 | -$3,803,435 | 4,144,037 | -6.1% | Franklin Resources, Inc. | 30 Sep 2025 |
| JANUS HENDERSON GROUP PLC | 10% | -12% | $44,484,293 | -$292,158,468 | 3,382,836 | -87% | JANUS HENDERSON GROUP PLC | 28 Nov 2025 |
| RA CAPITAL MANAGEMENT, L.P. | 5.5% | $24,327,500 | 1,850,000 | RA Capital Management, L.P. | 07 Nov 2025 | |||
| HBM Healthcare Investments (Cayman) Ltd. | 4.5% | $14,156,282 | 1,041,669 | HBM Healthcare Investments (Cayman) Ltd. | 31 Dec 2024 | |||
| Nantahala Capital Management, LLC | 4.4% | -53% | $14,111,462 | 1,038,371 | 0% | Nantahala Capital Management, LLC | 31 Mar 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 29% | 9,876,506 | 0% | 4.2% | $138,567,379 |
| JANUS HENDERSON GROUP PLC | 8.6% | 2,911,688 | +0.31% | 0.02% | $40,705,398 |
| FRANKLIN RESOURCES INC | 7.6% | 2,589,633 | -4.1% | 0.01% | $36,332,551 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5.8% | 1,972,524 | 0% | 0.04% | $27,674,512 |
| VANGUARD GROUP INC | 2.9% | 992,114 | +2.4% | 0% | $13,919,360 |
| BlackRock, Inc. | 2.8% | 945,515 | +32% | 0% | $13,265,576 |
| Nantahala Capital Management, LLC | 2.5% | 838,095 | 0% | 0.73% | $11,758,473 |
| INFINITUM ASSET MANAGEMENT, LLC | 1.5% | 500,000 | 0% | 1.3% | $7,015,000 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.3% | 438,505 | +5.6% | 0% | $6,153,972 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0.82% | 276,267 | +9.1% | 0.56% | $3,876,026 |
| Schonfeld Strategic Advisors LLC | 0.77% | 260,419 | +0% | 0.03% | $3,653,678 |
| STATE STREET CORP | 0.64% | 218,398 | +36% | 0% | $3,064,124 |
| GOLDMAN SACHS GROUP INC | 0.57% | 194,363 | +826% | 0% | $2,726,913 |
| AWM Investment Company, Inc. | 0.54% | 182,977 | +33% | 0.24% | $2,567,167 |
| AMERIPRISE FINANCIAL INC | 0.46% | 154,414 | +40% | 0% | $2,166,428 |
| NORTHERN TRUST CORP | 0.39% | 130,615 | +3.4% | 0% | $1,832,528 |
| UBS Group AG | 0.3% | 99,941 | +459% | 0% | $1,402,172 |
| Simplify Asset Management Inc. | 0.23% | 78,725 | +14% | 0.02% | $1,104,512 |
| ExodusPoint Capital Management, LP | 0.23% | 77,912 | +2% | 0.02% | $1,093,105 |
| MYDA Advisors LLC | 0.21% | 70,000 | +13% | 0.3% | $982,100 |
| Lion Point Capital, LP | 0.18% | 62,000 | 0% | 4.9% | $869,860 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.13% | 45,274 | 0% | 0% | $635,194 |
| Longaeva Partners L.P. | 0.11% | 37,537 | -28% | 0.11% | $526,644 |
| Bank of New York Mellon Corp | 0.1% | 34,001 | +6.4% | 0% | $477,034 |
| BARCLAYS PLC | 0.06% | 21,283 | -21% | 0% | $298,600 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 14,957 | $201,586 | +$110,987 | 1,347.7% | 2 |
| 2025 Q3 | 23,155,290 | $324,725,424 | +$6,865,160 | 1,403% | 54 |
| 2025 Q2 | 22,685,530 | $265,306,276 | +$16,737,178 | 1,170% | 56 |
| 2025 Q1 | 21,243,183 | $277,395,506 | +$28,289,371 | 1,301% | 37 |
| 2024 Q4 | 18,997,897 | $240,166,135 | +$64,576,294 | 1,263% | 30 |
| 2024 Q3 | 13,715,023 | $126,792,177 | +$73,385,856 | 919% | 25 |
| 2024 Q2 | 5,729,459 | $39,940,820 | +$31,087,038 | 699% | 18 |
| 2024 Q1 | 1,270,837 | $6,576,960 | +$379,920 | 524.99% | 13 |
| 2023 Q4 | 1,197,615 | $3,880,452 | -$214,565 | 323.01% | 13 |
| 2023 Q3 | 1,267,947 | $3,838,114 | +$3,838,114 | 302% | 11 |