| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10.7% | 0% | $324,340,276 | 3,372,923 | 0% | RA Capital Management, L.P. | 13 Nov 2025 | |
| BCLS Fund III Investments, LP | 9.99% | 0% | $289,290,002 | +$49,824,886 | 3,020,990 | +20.8% | BCLS Fund III Investments, LP | 30 Sep 2025 |
| Point72 Asset Management, L.P. | 6.2% | -17.5% | $151,115,887 | +$4,801,311 | 1,578,069 | +3.28% | Point72 Asset Management, L.P. | 30 Sep 2025 |
| BIOTECHNOLOGY VALUE FUND L P | 4.4% | -16% | $113,871,586 | -$21,545,460 | 1,189,165 | -15.9% | BVF PARTNERS L P/IL | 15 Oct 2025 |
| Vivo Opportunity Fund Holdings, L.P. | 4.6% | -2% | $59,424,730 | +$28,480,301 | 1,175,796 | +92% | Vivo Opportunity Fund Holdings, L.P. | 30 Jun 2025 |
| BlackRock, Inc. | 4.6% | -15% | $111,424,214 | +$5,356,584 | 1,163,607 | +5.05% | BlackRock, Inc. | 30 Sep 2025 |
| Adage Capital Management, L.P. | 4.97% | -45.2% | $55,594,000 | +$5,559,400 | 1,100,000 | +11.1% | Adage Capital Management, L.P. | 30 Jun 2025 |
| Paradigm Biocapital Advisors LP | 3.3% | -38.3% | $92,041,065 | -$16,034,916 | 961,164 | -14.8% | Paradigm BioCapital Advisors LP | 30 Sep 2025 |
| Venrock Healthcare Capital Partners III, L.P. | 3.2% | -67% | $32,299,508 | -$23,243,750 | 639,088 | -41.8% | Venrock Healthcare Capital Partners III, L.P. | 30 Jun 2025 |
| Commodore Capital LP | 2% | -58.3% | $56,019,600 | -$56,498,400 | 585,000 | -50.2% | Commodore Capital LP | 30 Sep 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 32,486,735 | $3,110,319,924 | +$679,671,198 | $95.76 | 167 |
| 2025 Q2 | 25,911,048 | $1,262,611,204 | +$803,273,260 | $48.71 | 106 |
| 2025 Q1 | 9,559,359 | $205,909,478 | +$57,592,846 | $21.54 | 45 |
| 2024 Q4 | 6,873,669 | $183,637,032 | +$100,865,295 | $26.88 | 40 |
| 2024 Q3 | 3,308,428 | $35,565,026 | +$20,361,776 | $10.75 | 27 |
| 2024 Q2 | 1,412,361 | $16,863,937 | +$16,863,734 | $11.94 | 25 |