SERA PROGNOSTICS, INC. - Class A Common Stock, par value $0.0001 per share (SERA) Institutional Ownership

13F Institutional Holders and Ownership History from Q3 2021 to Q4 2025

Type / Class
Equity / Class A Common Stock, par value $0.0001 per share
Symbol
SERA on Nasdaq
Shares outstanding
37,605,576
Price per share
$3.52
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
17,640,480
Total reported value
$52,067,649
% of total 13F portfolios
0%
Share change
-503,358
Value change
-$1,545,175
Number of holders
56
Price from insider filings
$3.52
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of SERA PROGNOSTICS, INC. - Class A Common Stock, par value $0.0001 per share (SERA) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
BAKER BROS. ADVISORS LP 16% $18,418,870 5,498,170 Baker Bros. Advisors LP 12 Feb 2025
Whetstone Capital Advisors, LLC 9.2% -7% $10,218,262 -$509,945 3,459,713 -4.8% Whetstone Capital Advisors, LLC 31 Dec 2025
Chione Ltd 7.6% $8,727,926 2,605,351 Chione Ltd. 11 Feb 2025
Aberdeen Group plc 6.1% $6,325,722 2,227,367 Aberdeen Group plc 30 Jun 2025
Vivo Capital IX, LLC 4.5% $5,528,974 1,650,440 Vivo Capital IX, LLC 31 Mar 2025

As of 31 Dec 2025, 56 institutional investors reported holding 17,640,480 shares of SERA PROGNOSTICS, INC. - Class A Common Stock, par value $0.0001 per share (SERA). This represents 47% of the company’s total 37,605,576 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of SERA PROGNOSTICS, INC. - Class A Common Stock, par value $0.0001 per share (SERA) together control 46% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
BAKER BROS. ADVISORS LP 15% 5,498,170 0% 0.09% $16,219,602
Whetstone Capital Advisors, LLC 9.2% 3,459,713 -4.8% 3.2% $10,206,153
Aberdeen Group plc 6.1% 2,279,699 0% 0.01% $6,725,112
Vivo Capital, LLC 4.4% 1,650,440 0% 0.31% $4,868,798
VANGUARD GROUP INC 3.3% 1,239,449 +1.8% 0% $3,656,375
CITADEL ADVISORS LLC 1.9% 707,614 +8.2% 0% $2,087,462
CAPTRUST FINANCIAL ADVISORS 1.4% 536,766 -11% 0% $1,583,460
GEODE CAPITAL MANAGEMENT, LLC 0.89% 334,639 +1.1% 0% $987,474
AWM Investment Company, Inc. 0.55% 207,382 0% 0.06% $611,777
BlackRock, Inc. 0.5% 186,751 +4.3% 0% $550,915
STATE STREET CORP 0.33% 124,792 0% 0% $368,136
MILLENNIUM MANAGEMENT LLC 0.3% 113,178 -11% 0% $333,875
GSA CAPITAL PARTNERS LLP 0.29% 107,235 +64% 0.03% $316,000
Corient Private Wealth LLC 0.27% 100,000 0% 0% $290,000
NORTHERN TRUST CORP 0.26% 96,535 +9.1% 0% $284,778
MORGAN STANLEY 0.22% 80,968 -3.6% 0% $238,856
Bank of New York Mellon Corp 0.2% 75,267 0% 0% $222,038
Perigon Wealth Management, LLC 0.19% 72,685 0% 0% $214,421
SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.19% 71,532 +220% 0% $211,019
JANE STREET GROUP, LLC 0.18% 68,826 0% $203,037
Requisite Capital Management, LLC 0.15% 55,648 0% 0.03% $164,162
Ballentine Partners, LLC 0.13% 49,664 0% 0% $146,509
BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.12% 45,705 0% 0% $134,830
Twelve Points Wealth Management LLC 0.12% 43,388 0% 0.04% $160,102
HighTower Advisors, LLC 0.11% 42,234 0% 0% $124,590

Institutional Holders of SERA PROGNOSTICS, INC. - Class A Common Stock, par value $0.0001 per share (SERA) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 17,640,480 $52,067,649 -$1,545,175 $2.95 56
2025 Q3 18,156,273 $55,563,958 -$1,352,150 $3.06 61
2025 Q2 18,609,445 $51,523,609 -$7,499,389 $2.77 57
2025 Q1 20,231,342 $74,421,380 +$7,360,509 $3.68 70
2024 Q4 18,080,486 $147,052,539 +$674,056 $8.14 71
2024 Q3 17,992,458 $140,341,925 +$11,126,226 $7.80 59
2024 Q2 16,578,359 $98,177,558 +$11,498,661 $5.92 65
2024 Q1 14,410,216 $131,132,861 +$33,173,495 $9.10 51
2023 Q4 10,917,569 $65,287,321 +$31,973,805 $5.98 45
2023 Q3 8,863,155 $16,485,265 -$2,039,479 $1.86 27
2023 Q2 9,516,701 $31,357,944 -$107,402 $3.30 32
2023 Q1 9,529,218 $36,496,581 +$11,033,423 $3.83 35
2022 Q4 7,042,648 $8,861,320 -$2,401,722 $1.26 29
2022 Q3 8,696,925 $13,914,096 +$64,785 $1.60 31
2022 Q2 8,655,188 $14,197,000 -$4,569,945 $1.64 27
2022 Q1 9,651,032 $36,596,601 +$1,338,975 $3.79 41
2021 Q4 9,279,441 $63,795,000 -$353,446 $6.87 36
2021 Q3 8,651,053 $96,148,000 +$96,147,999 $11.11 35