| Reporting Name | Ownership % | Change | Value $ | Shares owned | Change | Activity % | Price | Form | Report date | Filing time |
|---|---|---|---|---|---|---|---|---|---|---|
| RA Capital Management, L.P. | 9.9% | +13% | $662,816,935 | 6,666,837 | +1,105,478 | +20% | $99.42 | 13G/A | 31 Dec 2025 | 17 Feb 2026, 16:41 |
| RA Capital Management, L.P. | 8.7% | $482,169,825 | 5,561,359 | $86.70 | 13G/A | 30 Jun 2025 | 14 Aug 2025, 18:04 |
| Holdings date | Option | Weight | Change | Value $ | Shares | Change | Activity % | Price | All Holders |
|---|---|---|---|---|---|---|---|---|---|
| 31 Dec 2025 | 7.3% | +1.1% | $713,618,232 | 6,666,837 | +985,478 | +17% | $107.04 | Q4 2025 | |
| 30 Sep 2025 | 7.1% | +0.15% | $573,760,445 | 5,681,359 | +120,000 | +2.2% | $100.99 | Q3 2025 | |
| 30 Jun 2025 | 5.9% | -0.56% | $351,422,275 | 5,561,359 | -523,053 | -8.6% | $63.19 | Q2 2025 | |
| 31 Mar 2025 | 5.4% | 0% | $322,291,304 | 6,084,412 | 0 | $52.97 | Q1 2025 | ||
| 31 Dec 2024 | 4.5% | 0% | $340,605,384 | 6,084,412 | 0 | $55.98 | Q4 2024 | ||
| 30 Sep 2024 | 3.7% | 0% | $318,762,345 | 6,084,412 | 0 | $52.39 | Q3 2024 | ||
| 30 Jun 2024 | 3.3% | +0.39% | $249,825,957 | 6,084,412 | +754,000 | +14% | $41.06 | Q2 2024 | |
| 31 Mar 2024 | 2.9% | 0% | $230,966,752 | 5,330,412 | 0 | $43.33 | Q1 2024 | ||
| 31 Dec 2023 | 3.8% | -0.25% | $245,039,040 | 5,330,412 | -345,655 | -6.1% | $45.97 | Q4 2023 | |
| 30 Sep 2023 | 2.6% | 0% | $130,123,836 | 5,676,067 | 0 | $22.92 | Q3 2023 | ||
| 30 Jun 2023 | 1.8% | +0.05% | $93,598,345 | 5,676,067 | +160,000 | +2.9% | $16.49 | Q2 2023 | |
| 31 Mar 2023 | 2.2% | 0% | $98,406,635 | 5,516,067 | 0 | $17.84 | Q1 2023 | ||
| 31 Dec 2022 | 3.3% | +0.03% | $160,627,871 | 5,516,067 | +45,000 | +0.82% | $29.12 | Q4 2022 | |
| 30 Sep 2022 | 2.9% | +0.31% | $134,041,000 | 5,471,067 | +600,000 | +12% | $24.50 | Q3 2022 | |
| 30 Jun 2022 | 0.54% | 0% | $20,215,000 | 4,871,067 | 0 | $4.15 | Q2 2022 | ||
| 31 Mar 2022 | 1.2% | 0% | $56,115,000 | 4,871,067 | 0 | $11.52 | Q1 2022 | ||
| 31 Dec 2021 | 0.86% | 0% | $48,613,000 | 4,871,067 | 0 | $9.98 | Q4 2021 | ||
| 30 Sep 2021 | 0.88% | 0% | $63,616,000 | 4,871,067 | 0 | $13.06 | Q3 2021 | ||
| 30 Jun 2021 | 0% | $71,077,000 | 4,871,067 | 0 | $14.59 * | Q2 2021 | |||
| 31 Mar 2021 | 1.6% | +0.22% | $103,608,000 | 4,871,067 | +692,000 | +17% | $21.27 | Q1 2021 | |
| 31 Dec 2020 | 1.7% | -0.4% | $124,244,000 | 4,179,067 | -961,341 | -19% | $29.73 | Q4 2020 | |
| 30 Sep 2020 | 2% | -0.03% | $111,393,000 | 5,140,408 | -69,680 | -1.3% | $21.67 | Q3 2020 | |
| 30 Jun 2020 | 2.3% | -0.09% | $116,185,000 | 5,210,088 | -212,224 | -3.9% | $22.30 | Q2 2020 | |
| 31 Mar 2020 | 2.7% | 0% | $82,528,000 | 5,422,312 | 0 | $15.22 | Q1 2020 | ||
| 31 Dec 2019 | 3.8% | +1.4% | $124,496,000 | 5,422,312 | +2,000,000 | +58% | $22.96 | Q4 2019 | |
| 30 Sep 2019 | 4.4% | +2% | $73,888,000 | 3,422,312 | +1,537,530 | +82% | $21.59 | Q3 2019 | |
| 30 Jun 2019 | 2.4% | 0% | $41,465,000 | 1,884,782 | 0 | $22.00 | Q2 2019 | ||
| 31 Mar 2019 | 2.3% | -0.08% | $51,662,000 | 1,884,782 | -65,550 | -3.4% | $27.41 | Q1 2019 | |
| 31 Dec 2018 | 3.2% | 0% | $52,425,000 | 1,950,332 | 0 | $26.88 | Q4 2018 | ||
| 30 Sep 2018 | 3% | +0.64% | $56,891,000 | 1,950,332 | +408,589 | +27% | $29.17 | Q3 2018 | |
| 30 Jun 2018 | 3.1% | +3.1% | $48,195,000 | 1,541,743 | +1,541,743 | NEW | $31.26 | Q2 2018 |