| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 10% | -12% | $65,914,563 | +$10,720,599 | 7,291,434 | +19% | JANUS HENDERSON GROUP PLC | 28 Nov 2025 |
| BALYASNY ASSET MANAGEMENT L.P. | 9.9% | -1% | $53,656,154 | +$13,573,377 | 7,221,555 | +34% | Balyasny Asset Management L.P. | 31 Dec 2025 |
| CITADEL ADVISORS LLC | 7.4% | -22% | $40,851,767 | +$1,219,315 | 5,498,219 | +3.1% | Kenneth Griffin | 31 Dec 2025 |
| Affinity Asset Advisors, LLC | 7.1% | -8.1% | $51,813,451 | +$9,589,340 | 5,217,660 | +23% | Affinity Asset Advisors, LLC | 22 Jan 2026 |
| RA CAPITAL MANAGEMENT, L.P. | 6.9% | $33,200,000 | 5,000,000 | RA Capital Management, L.P. | 20 Oct 2025 | |||
| BlackRock, Inc. | 6.7% | +68% | $48,518,087 | +$26,984,571 | 4,885,814 | +125% | BlackRock, Inc. | 31 Dec 2025 |
| Paradigm Biocapital Advisors LP | 6.5% | +30% | $35,390,561 | +$8,107,609 | 4,763,198 | +30% | Paradigm BioCapital Advisors LP | 31 Dec 2025 |
| Vestal Point Capital, LP | 7.5% | +25% | $27,338,885 | +$5,903,896 | 4,117,302 | +28% | Vestal Point Capital, LP | 30 Sep 2025 |
| VANGUARD GROUP INC | 5.3% | $38,672,056 | 3,894,310 | The Vanguard Group | 31 Dec 2025 | |||
| Frazier Life Sciences Public Fund, L.P. | 5.1% | -10% | $27,478,154 | +$4,642,294 | 3,698,271 | +20% | Frazier Life Sciences Public Fund, L.P. | 31 Dec 2025 |
| Longitude Capital Partners IV, LLC | 3.8% | $18,362,130 | 2,765,381 | Longitude Capital Partners IV, LLC | 30 Sep 2025 | |||
| INTEGRATED CORE STRATEGIES (US) LLC | 3.2% | -42% | $15,362,583 | -$3,470,396 | 2,313,642 | -18% | Millennium Management LLC | 30 Sep 2025 |
| MIZUHO FINANCIAL GROUP INC | 6.6% | +13% | $8,109,362 | +$1,020,464 | 2,203,631 | +14% | Mizuho Financial Group, Inc. | 31 Mar 2025 |
| EVENTIDE ASSET MANAGEMENT, LLC | 3.7% | $4,544,189 | 1,234,834 | Eventide Asset Management, LLC | 31 Dec 2024 | |||
| Omega Fund VI, L.P. | 3.6% | $4,359,460 | 1,184,636 | Omega Fund VI, L.P. | 31 Dec 2024 | |||
| D1 Capital Partners L.P. | 2.9% | $3,601,439 | 978,652 | D1 Capital Partners L.P. | 31 Mar 2025 | |||
| Adage Capital Management, L.P. | 0.7% | -85% | $875,667 | -$7,255,716 | 237,953 | -89% | Adage Capital Management, L.P. | 31 Mar 2025 |
As of 31 Dec 2025, 144 institutional investors reported holding 76,458,029 shares of Lexeo Therapeutics, Inc. - Common Stock ($0.0001 par value) (the "Shares") (LXEO). This represents 103% of the company’s total 74,300,257 outstanding shares.
The largest institutional shareholders of Lexeo Therapeutics, Inc. - Common Stock ($0.0001 par value) (the "Shares") (LXEO) together control 90% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 7.4% | 5,509,635 | -9.8% | 0.02% | $54,668,943 |
| RA CAPITAL MANAGEMENT, L.P. | 6.7% | 5,000,000 | 0.51% | $49,650,000 | |
| BlackRock, Inc. | 6.6% | 4,907,563 | +126% | 0% | $48,732,100 |
| Paradigm Biocapital Advisors LP | 6.4% | 4,763,198 | 1.3% | $47,298,556 | |
| Vestal Point Capital, LP | 6% | 4,475,000 | +38% | 1.6% | $44,436,750 |
| Frazier Life Sciences Management, L.P. | 6% | 4,424,725 | 0% | 1.2% | $43,937,519 |
| VANGUARD GROUP INC | 5.2% | 3,894,310 | +75% | 0% | $38,670,499 |
| CITADEL ADVISORS LLC | 5.1% | 3,774,317 | +1.5% | 0.03% | $37,478,968 |
| Avoro Capital Advisors LLC | 4.4% | 3,300,000 | 0.32% | $32,769,000 | |
| Affinity Asset Advisors, LLC | 4.3% | 3,200,000 | -17% | 2.3% | $31,776,000 |
| Woodline Partners LP | 4.3% | 3,197,760 | +24% | 0.12% | $31,753,757 |
| STATE STREET CORP | 4.3% | 3,187,722 | +485% | 0% | $31,654,079 |
| ORBIMED ADVISORS LLC | 2.9% | 2,125,000 | 0.45% | $21,101,250 | |
| Point72 Asset Management, L.P. | 2.6% | 1,894,722 | -2.4% | 0.03% | $18,814,589 |
| Octagon Capital Advisors LP | 2.3% | 1,725,000 | 2.1% | $17,129,250 | |
| Balyasny Asset Management L.P. | 2.2% | 1,635,026 | -58% | 0.03% | $16,235,808 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.9% | 1,445,887 | +100% | 0% | $14,361,075 |
| ADAR1 Capital Management, LLC | 1.9% | 1,393,161 | -9.1% | 1% | $13,834,089 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1.7% | 1,250,000 | 0.31% | $12,412,500 | |
| 683 Capital Management, LLC | 1.5% | 1,120,000 | +21% | 0.92% | $11,121,600 |
| Nantahala Capital Management, LLC | 1.3% | 1,000,000 | 0.59% | $9,930,000 | |
| MILLENNIUM MANAGEMENT LLC | 1.2% | 908,024 | -61% | 0.01% | $9,016,678 |
| Blackstone Inc. | 1.2% | 904,959 | -20% | 0.04% | $8,986,243 |
| DIMENSIONAL FUND ADVISORS LP | 1.2% | 862,892 | -5.4% | 0% | $8,567,932 |
| GOLDMAN SACHS GROUP INC | 1.1% | 781,855 | +449% | 0% | $7,763,820 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 76,458,029 | $759,168,531 | +$269,432,782 | $9.93 | 144 |
| 2025 Q3 | 49,357,693 | $327,711,484 | +$52,680,502 | $6.64 | 109 |
| 2025 Q2 | 42,272,843 | $169,997,165 | +$59,022,508 | $4.02 | 90 |
| 2025 Q1 | 28,007,948 | $99,996,757 | -$11,520,766 | $3.47 | 88 |
| 2024 Q4 | 29,519,159 | $194,192,987 | -$4,086,062 | $6.58 | 89 |
| 2024 Q3 | 29,735,114 | $268,784,046 | +$10,322,355 | $9.04 | 67 |
| 2024 Q2 | 26,566,622 | $426,105,401 | +$55,254,655 | $16.04 | 57 |
| 2024 Q1 | 23,119,889 | $361,545,010 | +$108,427,159 | $15.68 | 54 |
| 2023 Q4 | 16,174,480 | $217,090,546 | +$217,090,546 | $13.42 | 31 |