| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Affinity Asset Advisors, LLC | 7.8% | $5,717,348 | 6,583,772 | Affinity Healthcare Fund, LP | 16 Oct 2025 | |||
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7.7% | $4,632,014 | 6,488,324 | Suvretta Capital Management, LLC | 30 Jun 2025 | |||
| MILLENNIUM MANAGEMENT LLC | 5.6% | $4,434,182 | 4,717,215 | Millennium Management LLC | 27 Jun 2025 | |||
| VANGUARD GROUP INC | 4.9% | $2,937,877 | 4,115,250 | The Vanguard Group | 30 Jun 2025 | |||
| BlackRock, Inc. | 2.5% | -69% | $1,493,679 | -$2,892,242 | 2,092,281 | -66% | BlackRock, Inc. | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7.7% | 6,488,324 | 0% | 0.17% | $5,634,461 |
| Kynam Capital Management, LP | 6% | 5,088,099 | 0% | 0.33% | $4,418,505 |
| MILLENNIUM MANAGEMENT LLC | 5.3% | 4,524,350 | -4.4% | 0% | $3,928,946 |
| VANGUARD GROUP INC | 4.3% | 3,682,986 | -11% | 0% | $3,196,832 |
| ACADIAN ASSET MANAGEMENT LLC | 4% | 3,389,322 | +11% | 0.01% | $2,941,000 |
| Velan Capital Investment Management LP | 3.7% | 3,120,000 | +2% | 2.5% | $2,709,408 |
| TANG CAPITAL MANAGEMENT LLC | 3.3% | 2,828,717 | +10% | 0.09% | $2,456,458 |
| Merck & Co., Inc. | 3.2% | 2,723,509 | 0% | 1% | $2,365,095 |
| Vestal Point Capital, LP | 3.1% | 2,600,000 | 0% | 0.1% | $2,257,840 |
| Eversept Partners, LP | 2.7% | 2,291,313 | -0.04% | 0.15% | $1,989,776 |
| SAMSARA BIOCAPITAL, LLC | 2.6% | 2,196,814 | 0% | 0.25% | $1,907,713 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2.4% | 2,000,000 | 0% | 0% | $1,736,800 |
| UBS Group AG | 2.2% | 1,845,839 | +14% | 0% | $1,602,188 |
| BlackRock, Inc. | 2% | 1,687,880 | -20% | 0% | $1,465,755 |
| RENAISSANCE TECHNOLOGIES LLC | 1.7% | 1,424,797 | +56% | 0% | $1,237,294 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.97% | 820,948 | +0.49% | 0% | $713,188 |
| Affinity Asset Advisors, LLC | 0.89% | 752,722 | 0% | 0.06% | $653,664 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0.53% | 445,750 | 0% | $387,089 | |
| DAFNA Capital Management LLC | 0.52% | 437,079 | 0% | 0.09% | $379,559 |
| TWO SIGMA INVESTMENTS, LP | 0.47% | 396,785 | +245% | 0% | $344,568 |
| AQR CAPITAL MANAGEMENT LLC | 0.42% | 354,449 | -65% | 0% | $307,804 |
| Fisher Asset Management, LLC | 0.42% | 352,949 | 0% | 0% | $306,500 |
| STATE STREET CORP | 0.4% | 342,652 | 0% | 0% | $297,559 |
| Shay Capital LLC | 0.37% | 312,051 | +20% | 0.05% | $270,985 |
| ROYAL BANK OF CANADA | 0.31% | 258,876 | +17% | 0% | $225,000 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 0 | $0 | -$40 | 0 | |
| 2025 Q3 | 53,391,796 | $46,361,876 | -$1,653,951 | 86.84% | 85 |
| 2025 Q2 | 55,585,121 | $39,680,994 | -$3,651,726 | 71.39% | 100 |
| 2025 Q1 | 61,457,334 | $39,985,859 | -$10,841,219 | 65.06% | 113 |
| 2024 Q4 | 63,895,959 | $117,565,386 | -$7,306,459 | 184% | 122 |
| 2024 Q3 | 62,516,525 | $216,373,636 | -$1,660,759 | 346% | 130 |
| 2024 Q2 | 63,167,394 | $185,075,042 | +$25,139,079 | 293% | 119 |
| 2024 Q1 | 53,412,221 | $301,719,025 | +$2,094,339 | 565% | 116 |
| 2023 Q4 | 55,648,249 | $238,729,642 | -$219,480 | 429% | 113 |
| 2023 Q3 | 55,996,442 | $194,308,615 | +$5,622,550 | 347% | 108 |
| 2023 Q2 | 54,105,078 | $251,585,717 | +$2,181,872 | 465% | 119 |
| 2023 Q1 | 53,720,779 | $247,499,715 | +$10,470,599 | 462% | 114 |
| 2022 Q4 | 49,984,035 | $403,859,817 | +$6,296,600 | 808% | 116 |
| 2022 Q3 | 50,396,383 | $279,697,401 | +$23,514,794 | 555% | 111 |
| 2022 Q2 | 46,245,672 | $240,931,373 | +$15,713,924 | 520.97% | 111 |
| 2022 Q1 | 41,606,389 | $341,990,813 | -$38,514,469 | 822% | 111 |
| 2021 Q4 | 39,677,298 | $590,411,817 | -$4,363,219 | 1,488% | 114 |
| 2021 Q3 | 39,817,120 | $752,214,523 | -$26,368,206 | 1,888.97% | 119 |
| 2021 Q2 | 41,241,047 | $766,657,023 | -$71,886,996 | 1,858.99% | 121 |
| 2021 Q1 | 44,209,991 | $1,005,487,689 | +$114,863,310 | 2,276% | 136 |
| 2020 Q4 | 39,392,744 | $855,224,796 | +$184,675,658 | 2,171% | 132 |
| 2020 Q3 | 31,151,440 | $313,088,624 | +$67,545,691 | 1,005% | 87 |
| 2020 Q2 | 23,997,579 | $186,238,799 | +$97,614,730 | 776% | 76 |
| 2020 Q1 | 11,868,607 | $116,270,683 | +$7,872,102 | 1,019.99% | 60 |
| 2019 Q4 | 11,616,437 | $127,772,633 | +$7,088,075 | 1,100% | 64 |
| 2019 Q3 | 11,074,608 | $91,621,057 | -$8,301,817 | 908.98% | 59 |
| 2019 Q2 | 11,817,484 | $122,739,770 | +$6,666,665 | 1,137.98% | 58 |
| 2019 Q1 | 11,231,778 | $116,185,606 | +$4,727,906 | 1,138.85% | 49 |
| 2018 Q4 | 9,707,399 | $87,234,000 | -$10,616,486 | 901.96% | 41 |
| 2018 Q3 | 9,086,875 | $135,767,000 | +$129,306,000 | 1,500% | 32 |