| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| TCG Crossover GP II, LLC | 9.2% | $29,600,000 | 10,000,000 | Chen Yu | 22 Oct 2025 | |||
| Polaris Venture Partners VI, L.P. | 6.5% | $21,001,943 | 7,095,251 | Terrance G. McGuire | 30 Sep 2025 | |||
| RTW INVESTMENTS, LP | 6.9% | $20,692,786 | 6,990,806 | RTW Investments, LP | 30 Sep 2025 | |||
| BlackRock, Inc. | 4.7% | -8% | $8,080,496 | -$33,208 | 5,179,805 | -0.41% | BlackRock, Inc. | 31 Dec 2025 |
| FMR LLC | 3.6% | $10,655,467 | 3,599,820 | FMR LLC | 31 Oct 2025 |
As of 30 Sep 2025, 146 institutional investors reported holding 74,753,323 shares of Alector, Inc. - Common Stock (ALEC). This represents 68% of the company’s total 110,208,617 outstanding shares.
The largest institutional shareholders of Alector, Inc. - Common Stock (ALEC) together control 57% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 14% | 15,181,849 | +1.2% | 0% | $44,938,273 |
| BlackRock, Inc. | 6.5% | 7,197,973 | -9.7% | 0% | $21,305,999 |
| RTW INVESTMENTS, LP | 6.3% | 6,990,806 | 0.25% | $20,692,786 | |
| VANGUARD GROUP INC | 5.5% | 6,034,659 | +0.78% | 0% | $17,862,591 |
| Merck & Co., Inc. | 3.2% | 3,545,719 | 0% | 4.6% | $10,495,328 |
| ACADIAN ASSET MANAGEMENT LLC | 2.2% | 2,372,985 | +9.3% | 0.01% | $7,016,000 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2% | 2,185,032 | -55% | 0% | $6,469,000 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.7% | 1,861,258 | -6.1% | 0% | $5,510,692 |
| STATE STREET CORP | 1.6% | 1,734,679 | +1.4% | 0% | $5,134,650 |
| Eversept Partners, LP | 1.4% | 1,488,725 | -25% | 0.34% | $4,406,626 |
| Euclidean Capital LLC | 1.2% | 1,307,858 | 0% | 1.6% | $3,871,260 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1.1% | 1,230,974 | -6.9% | 0.01% | $3,643,683 |
| MILLENNIUM MANAGEMENT LLC | 1% | 1,155,027 | +181% | 0% | $3,418,880 |
| DEUTSCHE BANK AG\ | 0.97% | 1,068,215 | +7.9% | 0% | $3,161,917 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0.96% | 1,055,192 | 0% | 0.05% | $3,123,368 |
| 683 Capital Management, LLC | 0.91% | 1,000,000 | 0.27% | $2,960,000 | |
| 5AM Venture Management, LLC | 0.9% | 995,841 | 0% | 1.1% | $2,947,689 |
| Vestal Point Capital, LP | 0.89% | 980,000 | +0.31% | 0.13% | $2,900,800 |
| D. E. Shaw & Co., Inc. | 0.89% | 978,204 | +83% | 0% | $2,895,484 |
| RENAISSANCE TECHNOLOGIES LLC | 0.86% | 949,150 | -24% | 0% | $2,809,484 |
| BARCLAYS PLC | 0.79% | 873,375 | +414% | 0% | $2,585,189 |
| DAFNA Capital Management LLC | 0.72% | 798,351 | -13% | 0.58% | $2,363,119 |
| Ikarian Capital, LLC | 0.69% | 760,000 | -16% | 0.51% | $2,249,601 |
| PANAGORA ASSET MANAGEMENT INC | 0.67% | 741,293 | +43% | 0.01% | $2,194,227 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.63% | 689,524 | +6.5% | 0% | $2,040,991 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 43,758 | $68,140 | -$206,077 | $1.56 | 5 |
| 2025 Q3 | 74,753,323 | $221,270,506 | +$17,828,715 | $2.96 | 146 |
| 2025 Q2 | 70,504,594 | $98,716,242 | -$652,478 | $1.40 | 134 |
| 2025 Q1 | 72,505,139 | $89,184,395 | -$1,704,057 | $1.23 | 139 |
| 2024 Q4 | 73,449,099 | $138,781,190 | -$36,884,482 | $1.89 | 147 |
| 2024 Q3 | 72,547,576 | $338,388,962 | -$1,018,637 | $4.66 | 158 |
| 2024 Q2 | 72,687,195 | $329,955,349 | -$13,884,915 | $4.54 | 157 |
| 2024 Q1 | 74,200,085 | $446,678,675 | +$61,253,193 | $6.02 | 156 |
| 2023 Q4 | 63,928,176 | $510,115,302 | +$16,550,304 | $7.98 | 144 |
| 2023 Q3 | 62,119,605 | $402,563,158 | +$20,670,443 | $6.48 | 145 |
| 2023 Q2 | 58,985,239 | $354,496,843 | +$4,367,360 | $6.01 | 142 |
| 2023 Q1 | 58,273,875 | $360,651,817 | +$17,929,999 | $6.19 | 144 |
| 2022 Q4 | 54,844,285 | $506,217,126 | -$5,426,867 | $9.23 | 154 |
| 2022 Q3 | 54,578,353 | $516,264,248 | +$5,671,869 | $9.46 | 162 |
| 2022 Q2 | 53,817,727 | $546,756,104 | -$17,438,158 | $10.16 | 148 |
| 2022 Q1 | 55,399,462 | $789,780,092 | -$5,073,123 | $14.25 | 159 |
| 2021 Q4 | 54,728,224 | $1,130,142,954 | +$66,134,357 | $20.65 | 160 |
| 2021 Q3 | 52,231,382 | $1,191,926,737 | +$72,825,941 | $22.82 | 144 |
| 2021 Q2 | 49,168,688 | $1,024,647,606 | +$63,360,607 | $20.83 | 133 |
| 2021 Q1 | 46,154,577 | $929,480,793 | +$13,141,895 | $20.14 | 123 |
| 2020 Q4 | 46,284,829 | $700,229,278 | -$61,389,553 | $15.13 | 130 |
| 2020 Q3 | 49,519,452 | $522,137,542 | -$50,083,788 | $10.54 | 136 |
| 2020 Q2 | 50,099,049 | $1,223,842,967 | +$53,677,644 | $24.44 | 133 |
| 2020 Q1 | 47,897,578 | $1,155,708,612 | +$264,293,053 | $24.13 | 102 |
| 2019 Q4 | 37,073,169 | $638,772,713 | +$44,393,449 | $17.23 | 81 |
| 2019 Q3 | 34,671,437 | $499,972,276 | +$80,611,697 | $14.42 | 74 |
| 2019 Q2 | 29,064,816 | $551,259,295 | +$7,378,322 | $19.00 | 63 |
| 2019 Q1 | 27,527,687 | $515,314,000 | +$515,304,000 | $18.72 | 53 |