| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BIOTECHNOLOGY VALUE FUND L P | 9.99% | 0% | $18,533,099 | +$5,333,230 | 1,458,151 | +40.4% | BVF PARTNERS L P/IL | 30 Sep 2025 |
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | 0% | $17,618,183 | +$3,708,270 | 1,386,167 | +26.7% | RA Capital Management, L.P. | 30 Sep 2025 |
| Nantahala Capital Management, LLC | 9.39% | +12% | $15,696,850 | +$4,257,850 | 1,235,000 | +37.2% | Nantahala Capital Management, LLC | 30 Sep 2025 |
| Point72 Asset Management, L.P. | 8% | +52% | $13,396,124 | +$5,914,611 | 1,053,983 | +79.1% | Point72 Asset Management, L.P. | 30 Sep 2025 |
| Affinity Asset Advisors, LLC | 7.65% | +47% | $12,789,018 | +$5,788,795 | 1,006,217 | +82.7% | Affinity Healthcare Fund, LP | 30 Sep 2025 |
| ORBIMED ADVISORS LLC | 8.9% | $4,622,260 | 967,000 | OrbiMed Advisors LLC | 30 Jun 2025 | |||
| Caligan Partners LP | 6.3% | $10,591,662 | 833,333 | Caligan Partners LP | 30 Sep 2025 | |||
| BALYASNY ASSET MANAGEMENT L.P. | 6.22% | $10,389,612 | 817,436 | Balyasny Asset Management L.P. | 30 Sep 2025 | |||
| SILVERARC CAPITAL MANAGEMENT, LLC | 5.48% | $9,162,919 | 720,922 | SilverArc Capital Management, LLC | 30 Sep 2025 | |||
| Ikarian Capital, LLC | 3.8% | -61.9% | $9,049,101 | -$6,100,673 | 711,967 | -40.3% | Ikarian Capital, LLC | 30 Sep 2025 |
| VANGUARD GROUP INC | 5.26% | $8,803,416 | 692,637 | The Vanguard Group | 30 Sep 2025 | |||
| Crutcher Patrick J | 4.2% | $3,593,514 | 549,467 | Patrick J. Crutcher | 06 Aug 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 15,317,685 | $194,685,792 | +$95,069,684 | $12.71 | 65 |
| 2025 Q2 | 7,843,040 | $39,137,186 | -$2,087,558 | $4.99 | 35 |
| 2025 Q1 | 8,255,057 | $66,123,710 | +$5,779,142 | $8.01 | 33 |
| 2024 Q4 | 7,530,521 | $55,951,612 | +$4,829,815 | $7.43 | 33 |
| 2024 Q3 | 6,656,933 | $63,199,568 | +$55,874,127 | $9.5 | 28 |
| 2024 Q2 | 771,102 | $9,615,066 | +$8,430,049 | $12.47 | 21 |
| 2024 Q1 | 87,507 | $1,897,924 | +$1,405,693 | $21.75 | 18 |
| 2023 Q4 | 22,966 | $209,366 | +$209,366 | $9 | 12 |