| Sym | Company | Class | Ownership | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|
Sym | Company | Class | Ownership | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|---|
| MNPR | MONOPAR THERAPEUTICS INC | Common Stock | 18.6% | $50.6M | $3.9M | 1.13M | +8.36% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| DRUG | BRIGHT MINDS BIOSCIENCES INC. | Common Stock | 16% | $34.3M | $9.46M | 1.11M | +38.1% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| MREO | MEREO BIOPHARMA GROUP PLC | American Depositary Shares | 14.3% | $59.3M | $17.8M | 22.7M | +42.8% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| AVDL | AVADEL PHARMACEUTICALS PLC | Common Stock | 14.1% | $119M | -$4.28M | 13.6M | -3.47% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| ETNB | 89BIO, INC. | Common Stock | 14% | $141M | $1.44M | 20.5M | +1.03% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| LXEO | LEXEO THERAPEUTICS, INC. | Common Stock | 13.7% | $16.8M | $805K | 4.56M | +5.04% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| CMPR | CIMPRESS PLC | Common Stock | 13.3% | $140M | $10.8M | 3.3M | +8.36% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| CCSI | Consensus Cloud Solutions, Inc. | Common Stock | 12.8% | $50M | $794K | 2.49M | +1.61% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| BNTC | BENITEC BIOPHARMA INC. | Common Stock | 11.4% | $39.7M | $4.11M | 2.92M | +11.6% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| PCVX | VAXCYTE, INC. | Common Stock | 11.3% | $478M | $130M | 14.5M | +37.5% | JANUS HENDERSON GROUP PLC | Apr 30, 2025 |
| PRAX | PRAXIS PRECISION MEDICINES, INC | Common Stock | 11.3% | $89.6M | $29.7M | 2.3M | +49.5% | JANUS HENDERSON GROUP PLC | May 30, 2025 |
| SLNO | SOLENO THERAPEUTICS, INC. | Common Stock | 11.2% | $379M | -$2.62M | 5.15M | -0.69% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| ARDX | ARDELYX, INC. | Common Stock | 10.5% | $136M | $3.22M | 25M | +2.42% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| TARA | PROTARA THERAPEUTICS, INC. | Common Stock | 10.5% | $16.7M | $321K | 3.86M | +1.96% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| WEX | WEX, Inc. | Common Stock | 10.3% | $521M | -$5.73M | 4.01M | -1.09% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| MIRM | MIRUM PHARAMACEUTICALS, INC. | Common Stock | 10.3% | $230M | $3.76M | 5.08M | +1.66% | JANUS HENDERSON GROUP PLC | May 30, 2025 |
| LNTH | LANTHEUS HOLDINGS, INC. | Common Stock | 10.1% | $569M | $35.9M | 6.96M | +6.75% | JANUS HENDERSON GROUP PLC | May 30, 2025 |
| MDGL | MADRIGAL PHARMACEUTICALS, INC. | Common Stock | 10% | $752M | -$821K | 2.21M | -0.11% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| ICUI | ICU MEDICAL, INC. | Common Stock | 10% | $335M | $7.79M | 2.47M | +2.38% | JANUS HENDERSON GROUP PLC | Apr 30, 2025 |
| FBRX | FORTE BIOSCIENCES, INC. | Common Stock | 9.9% | $4.85M | -$245K | 658K | -4.81% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| TENX | TENAX THERAPEUTICS, INC. | Common Stock | 9.9% | $2.33M | $1.2M | 397K | +105% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| TFX | TELEFLEX INCORPORATED | Common Stock | 9.7% | $585M | -$126M | 4.33M | -17.7% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| RNA | AVIDITY BIOSCIENCES, INC. | Common Stock | 9.5% | $355M | $136M | 11.5M | +62.5% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| DYN | DYNE THERAPEUTICS INC | Common Stock | 9.2% | $115M | $33M | 10.4M | +40.3% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| SGRY | SURGERY PARTNERS, INC. | Common Stock | 9.1% | $260M | -$11.3M | 11.6M | -4.16% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| AKRO | AKERO THERAPEUTICS, INC. | Ordinary Shares | 8.9% | $290M | $42.4M | 7.07M | +17.1% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| LRMR | LARIMAR THERAPEUTICS, INC. | Common Stock | 8.7% | $13M | -$2.03M | 5.57M | -13.5% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| TVTX | TRAVERE THERAPEUTICS, INC | Common Stock | 8.5% | $139M | 7.57M | JANUS HENDERSON GROUP PLC | Mar 31, 2025 | ||
| ZD | ZIFF DAVIS, INC. | Common Stock | 8.3% | $110M | $1.71M | 3.54M | +1.58% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| JANX | JANUX THERAPEUTICS, INC. | Common Stock | 7.8% | $147M | $33.2M | 4.6M | +29.1% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| GPCR | STRUCTURE THERAPEUTICS INC | American Depositary Shares | 7.6% | $113M | $5.07M | 4.36M | +4.7% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| ASND | ASCENDIS PHARMA A/S | American Depositary Shares | 7.4% | $722M | $18.7M | 4.5M | +2.66% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| OSIS | OSI SYSTEMS, INC. | Common Stock | 7.4% | $250M | $970K | 1.24M | +0.39% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| IDYA | IDEAYA BIOSCIENCES, INC. | Common Stock | 7.3% | $122M | $10.4M | 6.4M | +9.3% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| FLEX | FLEX LTD. | Ordinary Shares | 6.9% | $918M | -$6.03M | 26.3M | -0.65% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| SSNC | SS&C TECHNOLOGIES HOLDINGS, INC. | Common Stock | 6.6% | $1.73B | $519M | 23.7M | +43% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| ST | SENSATA TECHNOLOGIES HOLDING PLC | Ordinary Shares | 6.6% | $212M | $3.11M | 9.91M | +1.49% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| OABI | OMNIAB, INC. | Common Stock | 6.6% | $14.7M | 8.06M | JANUS HENDERSON GROUP PLC | Mar 31, 2025 | ||
| SKIN | The Beauty Health Company | Common Stock | 6.6% | $8.34M | -$2.87M | 8.26M | -25.6% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| VRNA | VERONA PHARMA PLC | American Depositary Shares | 6.5% | $363M | 5.54M | JANUS HENDERSON GROUP PLC | Mar 31, 2025 | ||
| FWONK | LIBERTY MEDIA CORPORATION | Series C Liberty Formula One Common Stock | 6.4% | $1.12B | -$16.4M | 14.3M | -1.44% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| GIL | GILDAN ACTIVEWEAR INC | Common Stock | 6.4% | $415M | 9.78M | JANUS HENDERSON GROUP PLC | Mar 31, 2025 | ||
| ASUR | ASURE SOFTWARE INC | Class A Common Stock | 6.4% | $16.7M | $41.6K | 1.72M | +0.25% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| BHVN | BIOHAVEN LTD. | Common Stock | 6.3% | $141M | -$11.9M | 6.44M | -7.78% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| ARMK | ARAMARK | Common Stock | 6.2% | $546M | $8.64M | 16.5M | +1.61% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| GMED | GLOBUS MEDICAL, INC. | Class A Common Stock | 6.1% | $522M | $30.8M | 7.03M | +6.27% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| DOX | AMDOCS LIMITED | Ordinary Shares | 6% | $574M | $8.58M | 6.69M | +1.52% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| MAZE | MAZE THERAPEUTICS, INC | Common Stock | 5.7% | $22M | 2.5M | JANUS HENDERSON GROUP PLC | Mar 31, 2025 | ||
| EWTX | EDGEWISE THERAPEUTICS, INC. | Common Stock | 5.6% | $81.3M | $4.59M | 5.28M | +5.98% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |
| TRDA | ENTRADA THERAPEUTICS, INC. | Common Stock | 5.6% | $19M | $370K | 2.12M | +1.98% | JANUS HENDERSON GROUP PLC | Mar 31, 2025 |