| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 10.6% | +6% | $388,340,181 | +$31,912,348 | 5,445,039 | +9% | JANUS HENDERSON GROUP PLC | 28 Nov 2025 |
| Frazier Life Sciences IX, L.P. | 7.4% | 0% | $273,828,978 | 3,735,220 | 0% | James N. Topper | 01 Nov 2025 | |
| EVENTIDE ASSET MANAGEMENT, LLC | 5.43% | $107,692,609 | 2,606,938 | Eventide Asset Management, LLC | 31 Dec 2024 | |||
| BIOTECHNOLOGY VALUE FUND L P | 3% | $109,619,710 | 1,495,290 | BVF PARTNERS L P/IL | 30 Sep 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 57,250,607 | $4,197,040,984 | +$132,882,990 | $73.31 | 266 |
| 2025 Q2 | 55,393,029 | $2,819,019,204 | +$70,434,976 | $50.89 | 211 |
| 2025 Q1 | 54,142,705 | $2,443,759,313 | +$49,081,267 | $45.05 | 213 |
| 2024 Q4 | 52,986,109 | $2,190,964,431 | -$26,045,809 | $41.35 | 204 |
| 2024 Q3 | 53,301,609 | $2,079,251,226 | -$2,890,149 | $39 | 176 |
| 2024 Q2 | 53,362,791 | $1,824,471,702 | +$17,964,526 | $34.19 | 157 |
| 2024 Q1 | 53,243,448 | $1,337,601,222 | +$70,337,692 | $25.12 | 167 |
| 2023 Q4 | 50,259,606 | $1,483,847,413 | +$1,676,068 | $29.52 | 184 |
| 2023 Q3 | 48,930,333 | $1,545,592,030 | +$398,674,334 | $31.6 | 156 |
| 2023 Q2 | 36,937,639 | $955,518,729 | +$63,103,719 | $25.87 | 143 |
| 2023 Q1 | 34,669,406 | $832,753,531 | +$33,992,984 | $24.02 | 114 |
| 2022 Q4 | 33,331,988 | $650,146,380 | -$12,725,497 | $19.5 | 101 |
| 2022 Q3 | 33,748,714 | $709,089,633 | +$93,197,315 | $21.01 | 107 |
| 2022 Q2 | 29,289,263 | $568,434,366 | +$47,575,699 | $19.46 | 104 |
| 2022 Q1 | 26,813,353 | $590,437,915 | -$6,195,298 | $22.02 | 99 |
| 2021 Q4 | 22,891,220 | $365,087,000 | +$18,990,411 | $15.95 | 81 |
| 2021 Q3 | 21,414,209 | $426,514,254 | +$2,080,056 | $19.92 | 69 |
| 2021 Q2 | 21,482,092 | $371,413,185 | +$642,669 | $17.29 | 66 |
| 2021 Q1 | 21,451,984 | $425,174,000 | -$8,433,468 | $19.82 | 60 |
| 2020 Q4 | 22,010,623 | $384,380,000 | +$52,268,047 | $17.46 | 71 |
| 2020 Q3 | 18,743,135 | $361,180,000 | -$1,290,295 | $19.27 | 50 |
| 2020 Q2 | 18,808,446 | $366,015,000 | +$8,936,163 | $19.46 | 57 |
| 2020 Q1 | 18,603,225 | $260,445,000 | +$32,083,278 | $14 | 43 |
| 2019 Q4 | 16,248,910 | $398,421,000 | +$12,819,124 | $24.52 | 39 |
| 2019 Q3 | 16,487,274 | $165,856,000 | +$165,755,000 | $10.06 | 38 |