| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 10.6% | +6% | $388M | $31.9M | 5.45M | +8.95% | JANUS HENDERSON GROUP PLC | Nov 28, 2025 |
| Frazier Life Sciences IX, L.P. | 7.4% | 0% | $274M | 3.74M | 0% | James N. Topper | Nov 1, 2025 | |
| EVENTIDE ASSET MANAGEMENT, LLC | 5.43% | $108M | 2.61M | Eventide Asset Management, LLC | Dec 31, 2024 | |||
| BIOTECHNOLOGY VALUE FUND L P | 3% | $110M | 1.5M | BVF PARTNERS L P/IL | Sep 30, 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 57.3M | $4.2B | +$133M | $73.31 | 266 |
| 2025 Q2 | 55.4M | $2.82B | +$70.4M | $50.89 | 211 |
| 2025 Q1 | 54.1M | $2.44B | +$49.1M | $45.05 | 213 |
| 2024 Q4 | 53M | $2.19B | -$16.4M | $41.35 | 204 |
| 2024 Q3 | 53.1M | $2.07B | -$12.7M | $39.00 | 178 |
| 2024 Q2 | 53.4M | $1.82B | +$11.9M | $34.19 | 160 |
| 2024 Q1 | 53.2M | $1.34B | +$75.9M | $25.12 | 168 |
| 2023 Q4 | 49.7M | $1.47B | -$8.75M | $29.52 | 185 |
| 2023 Q3 | 48.7M | $1.54B | +$392M | $31.60 | 157 |
| 2023 Q2 | 36.9M | $956M | +$63.1M | $25.87 | 144 |
| 2023 Q1 | 34.7M | $833M | +$34M | $24.02 | 114 |
| 2022 Q4 | 33.3M | $650M | -$12.4M | $19.50 | 101 |
| 2022 Q3 | 33.7M | $709M | +$93.2M | $21.01 | 106 |
| 2022 Q2 | 29.3M | $568M | +$47.5M | $19.46 | 103 |
| 2022 Q1 | 26.8M | $590M | -$6.24M | $22.02 | 98 |
| 2021 Q4 | 22.9M | $365M | +$18.8M | $15.95 | 80 |
| 2021 Q3 | 21.4M | $427M | +$2.08M | $19.92 | 69 |
| 2021 Q2 | 21.5M | $371M | +$643K | $17.29 | 66 |
| 2021 Q1 | 21.5M | $425M | -$8.43M | $19.82 | 60 |
| 2020 Q4 | 22M | $384M | +$52.3M | $17.46 | 71 |
| 2020 Q3 | 18.7M | $361M | -$1.29M | $19.27 | 50 |
| 2020 Q2 | 18.8M | $366M | +$8.94M | $19.46 | 57 |
| 2020 Q1 | 18.6M | $260M | +$32.1M | $14.00 | 43 |
| 2019 Q4 | 16.2M | $398M | +$12.8M | $24.52 | 39 |
| 2019 Q3 | 16.5M | $166M | +$166M | $10.06 | 38 |