| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| 5AM Ventures V, L.P. | 11% | $25,485,387 | 4,123,849 | Kush Parmar | 14 Nov 2025 | |||
| ROCHE FINANCE LTD | 6.9% | $23,019,270 | 2,569,115 | Roche Finance Ltd | 31 Dec 2024 | |||
| BlackRock, Inc. | 5.3% | $17,691,090 | 1,974,452 | BlackRock, Inc. | 31 Dec 2024 | |||
| TCG Crossover GP I, LLC | 5% | $11,849,186 | 1,917,344 | TCG Crossover GP I, LLC | 19 Nov 2025 | |||
| JANUS HENDERSON GROUP PLC | 4% | -27% | $9,964,391 | -$3,932,443 | 1,521,281 | -28% | JANUS HENDERSON GROUP PLC | 30 Jun 2025 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0.9% | -84% | $2,091,051 | -$12,800,322 | 360,526 | -86% | T. Rowe Price Associates, Inc. | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 13% | 4,865,819 | 0% | 0.2% | $28,221,750 |
| MPM ASSET MANAGEMENT LLC | 11% | 4,381,062 | 0% | 57% | $25,410,160 |
| 5AM Venture Management, LLC | 11% | 4,256,379 | -1.2% | 9% | $24,686,998 |
| BlackRock, Inc. | 5.3% | 2,044,044 | +1.1% | 0% | $11,855,456 |
| VANGUARD GROUP INC | 4.2% | 1,604,225 | -0.04% | 0% | $9,304,505 |
| WELLINGTON MANAGEMENT GROUP LLP | 2.5% | 954,419 | -10% | 0% | $5,535,630 |
| MILLENNIUM MANAGEMENT LLC | 2.2% | 836,609 | +391% | 0% | $4,852,332 |
| StepStone Group LP | 2% | 761,277 | 0% | 2.2% | $4,415,407 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.7% | 645,119 | +2.1% | 0% | $3,742,489 |
| RENAISSANCE TECHNOLOGIES LLC | 1.5% | 594,300 | +57% | 0% | $3,446,940 |
| TCG Crossover Management, LLC | 1.5% | 584,955 | 0% | 0.17% | $3,392,739 |
| STATE STREET CORP | 1.3% | 498,615 | +0.56% | 0% | $2,891,967 |
| DIMENSIONAL FUND ADVISORS LP | 1% | 394,279 | -7% | 0% | $2,286,957 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0.94% | 360,526 | -86% | 0% | $2,092,000 |
| MORGAN STANLEY | 0.9% | 346,756 | +113% | 0% | $2,011,185 |
| ROYCE & ASSOCIATES LP | 0.9% | 345,507 | +55% | 0.02% | $2,003,941 |
| CITADEL ADVISORS LLC | 0.88% | 335,741 | +235% | 0% | $1,947,298 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0.82% | 315,810 | +43% | 0.01% | $1,831,698 |
| ACADIAN ASSET MANAGEMENT LLC | 0.78% | 297,943 | +550% | 0% | $1,724,000 |
| Qube Research & Technologies Ltd | 0.75% | 287,873 | +115% | 0% | $1,669,663 |
| NORTHERN TRUST CORP | 0.66% | 253,607 | -16% | 0% | $1,470,920 |
| JANE STREET GROUP, LLC | 0.65% | 247,516 | +384% | 0% | $1,435,593 |
| GOLDMAN SACHS GROUP INC | 0.58% | 222,336 | +164% | 0% | $1,289,550 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.48% | 185,259 | -9% | 0% | $1,074,502 |
| BNP PARIBAS FINANCIAL MARKETS | 0.39% | 148,212 | 0% | 0% | $859,630 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 4,328 | $44,493 | +$2,869 | $10.28 | 4 |
| 2025 Q3 | 28,408,649 | $164,766,258 | -$9,410,252 | $5.80 | 113 |
| 2025 Q2 | 29,583,750 | $198,790,015 | -$4,881,409 | $6.72 | 105 |
| 2025 Q1 | 30,241,830 | $274,509,238 | -$4,478,805 | $9.04 | 110 |
| 2024 Q4 | 30,637,008 | $529,755,566 | +$9,629,460 | $17.29 | 102 |
| 2024 Q3 | 30,099,996 | $481,057,545 | +$6,089,620 | $15.98 | 97 |
| 2024 Q2 | 29,668,185 | $422,803,373 | +$52,052,901 | $14.25 | 82 |
| 2024 Q1 | 26,027,444 | $368,797,900 | -$3,772,264 | $14.17 | 76 |
| 2023 Q4 | 26,281,861 | $396,641,035 | +$3,492,844 | $15.09 | 62 |
| 2023 Q3 | 26,035,608 | $411,375,608 | +$4,515,692 | $15.80 | 55 |
| 2023 Q2 | 25,751,810 | $389,877,766 | +$13,317,282 | $15.14 | 56 |
| 2023 Q1 | 24,900,040 | $361,043,649 | +$2,708,627 | $14.50 | 53 |
| 2022 Q4 | 24,715,588 | $334,178,958 | +$2,434,963 | $13.52 | 46 |
| 2022 Q3 | 24,517,008 | $386,369,092 | -$2,728,204 | $15.76 | 33 |
| 2022 Q2 | 24,778,477 | $301,833,417 | -$12,927,920 | $12.18 | 35 |
| 2022 Q1 | 25,876,494 | $242,821,140 | +$2,263,033 | $9.39 | 48 |
| 2021 Q4 | 24,861,440 | $425,110,000 | +$413,748,000 | $17.12 | 45 |