| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 8.3% | -16% | $845,168,195 | -$160,101,236 | 1,842,690 | -16% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
| FRIEDMAN PAUL A | 7.8% | $982,730,986 | 1,814,831 | Paul A Friedman, M.D. | 10 Dec 2025 | |||
| Taub Rebecca | 7.8% | $982,730,986 | 1,814,831 | Rebecca Taub, M.D. | 10 Dec 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 9.2% | 2,141,701 | +8.4% | 7.1% | $982,312,581 |
| RTW INVESTMENTS, LP | 8.6% | 1,993,687 | 0% | 11% | $914,424,479 |
| PAULSON & CO. INC. | 8.2% | 1,907,523 | -8.7% | 29% | $874,904,499 |
| JANUS HENDERSON GROUP PLC | 7.9% | 1,842,690 | -16% | 0.39% | $845,277,273 |
| Avoro Capital Advisors LLC | 7.9% | 1,833,000 | -2.2% | 11% | $840,723,780 |
| VANGUARD GROUP INC | 7.8% | 1,812,054 | -3.5% | 0.01% | $831,116,688 |
| BlackRock, Inc. | 6.7% | 1,559,712 | +8.4% | 0.01% | $715,377,705 |
| STATE STREET CORP | 2.8% | 658,097 | -4.7% | 0.01% | $301,842,770 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.9% | 446,233 | +7.7% | 0.01% | $204,700,716 |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1.8% | 411,802 | +18% | 0.49% | $188,877,105 |
| WELLINGTON MANAGEMENT GROUP LLP | 1.7% | 404,455 | +5381% | 0.03% | $185,507,331 |
| FMR LLC | 1.7% | 401,136 | -9.9% | 0.01% | $183,985,076 |
| GOLDMAN SACHS GROUP INC | 1.7% | 386,100 | +103% | 0.03% | $177,088,626 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.5% | 352,520 | -31% | 0.02% | $161,688,000 |
| Invesco Ltd. | 1.3% | 299,565 | +50% | 0.02% | $137,398,483 |
| Polar Capital Holdings Plc | 1.1% | 265,154 | +18% | 0.59% | $121,615,534 |
| MORGAN STANLEY | 1.1% | 249,647 | +0.68% | 0.01% | $114,503,407 |
| BANK OF AMERICA CORP /DE/ | 1% | 244,292 | -12% | 0.01% | $112,046,969 |
| Hood River Capital Management LLC | 1% | 242,808 | -0.79% | 1.3% | $111,366,317 |
| UBS Group AG | 0.93% | 217,343 | -57% | 0.02% | $99,686,540 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.92% | 213,652 | +40% | 0.02% | $97,993,626 |
| Artisan Partners Limited Partnership | 0.89% | 206,254 | +2.3% | 0.14% | $94,600,460 |
| Erste Asset Management GmbH | 0.86% | 201,100 | 0% | 0.86% | $89,107,410 |
| Pictet Asset Management Holding SA | 0.82% | 191,796 | -7.9% | 0.08% | $87,710,002 |
| AMERICAN CENTURY COMPANIES INC | 0.71% | 165,615 | -1.3% | 0.04% | $75,961,972 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 3,762 | $2,153,304 | +$937,144 | $582.34 | 8 |
| 2025 Q3 | 23,388,615 | $10,723,071,814 | -$21,947,854 | $458.66 | 349 |
| 2025 Q2 | 23,552,943 | $7,127,866,991 | -$58,976,553 | $302.64 | 303 |
| 2025 Q1 | 23,618,790 | $7,815,274,189 | +$242,480,129 | $331.23 | 317 |
| 2024 Q4 | 22,954,039 | $7,083,805,672 | +$127,209,746 | $308.57 | 282 |
| 2024 Q3 | 22,638,348 | $4,763,047,302 | -$106,585,037 | $212.22 | 252 |
| 2024 Q2 | 22,870,011 | $6,408,116,328 | +$504,945,812 | $280.16 | 255 |
| 2024 Q1 | 21,107,869 | $5,634,735,243 | +$377,318,349 | $267.04 | 263 |
| 2023 Q4 | 19,769,303 | $4,574,587,850 | +$602,581,939 | $231.38 | 225 |
| 2023 Q3 | 17,386,191 | $2,539,343,386 | +$349,378,221 | $146.04 | 206 |
| 2023 Q2 | 14,848,153 | $3,429,412,203 | +$220,213,706 | $231.00 | 208 |
| 2023 Q1 | 13,867,567 | $3,359,361,973 | +$106,522,160 | $242.26 | 221 |
| 2022 Q4 | 13,305,897 | $3,862,135,682 | +$567,009,121 | $290.25 | 186 |
| 2022 Q3 | 11,751,595 | $763,791,382 | -$25,263,206 | $64.99 | 133 |
| 2022 Q2 | 12,001,137 | $857,568,681 | -$17,315,431 | $71.58 | 130 |
| 2022 Q1 | 12,025,725 | $1,179,864,073 | +$26,264,521 | $98.12 | 132 |
| 2021 Q4 | 11,953,948 | $1,012,214,597 | +$40,893,478 | $84.74 | 139 |
| 2021 Q3 | 10,962,747 | $874,847,601 | -$34,316,604 | $79.79 | 126 |
| 2021 Q2 | 11,229,236 | $1,093,866,439 | -$99,083,348 | $97.41 | 147 |
| 2021 Q1 | 12,210,439 | $1,427,893,568 | -$10,189,929 | $116.97 | 135 |
| 2020 Q4 | 12,273,522 | $1,364,432,852 | +$68,881,092 | $111.17 | 132 |
| 2020 Q3 | 11,637,870 | $1,381,764,563 | +$46,463,709 | $118.73 | 125 |
| 2020 Q2 | 11,257,505 | $1,274,820,026 | +$4,793,161 | $113.25 | 124 |
| 2020 Q1 | 11,048,035 | $737,557,931 | +$26,608,051 | $66.76 | 106 |
| 2019 Q4 | 10,473,886 | $954,273,764 | +$65,909,446 | $91.11 | 119 |
| 2019 Q3 | 9,642,874 | $831,383,218 | -$23,303 | $86.22 | 108 |
| 2019 Q2 | 9,609,887 | $1,007,125,218 | +$10,337,419 | $104.81 | 115 |
| 2019 Q1 | 9,458,074 | $1,184,436,498 | +$61,292,852 | $125.26 | 133 |
| 2018 Q4 | 8,980,955 | $1,012,211,915 | -$4,919,869 | $112.72 | 130 |
| 2018 Q3 | 8,620,856 | $1,846,093,673 | +$62,737,488 | $214.13 | 153 |
| 2018 Q2 | 8,122,360 | $2,271,715,929 | +$574,219,732 | $279.69 | 148 |
| 2018 Q1 | 6,326,097 | $738,823,289 | +$151,724,184 | $116.79 | 98 |
| 2017 Q4 | 5,126,558 | $470,559,417 | +$234,134,618 | $91.79 | 88 |
| 2017 Q3 | 2,673,071 | $120,236,161 | +$28,988,629 | $44.98 | 50 |
| 2017 Q2 | 2,046,899 | $33,282,527 | +$8,857,871 | $16.26 | 39 |
| 2017 Q1 | 1,529,190 | $23,547,216 | +$3,024,176 | $15.40 | 25 |
| 2016 Q4 | 1,345,552 | $20,048,209 | +$6,295,667 | $14.90 | 24 |
| 2016 Q3 | 1,006,962 | $12,766,000 | +$12,739,000 | $12.67 | 24 |
| 2016 Q2 | 79,573 | $21,000 | +$21,000 | $0.2639 | 1 |