Security Snapshot

ACHIEVE LIFE SCIENCES, INC. - Common Stock, par value $0.001 per share (ACHV) Institutional Ownership

CUSIP: 004468500

13F Institutional Holders and Ownership History from Q3 2020 to Q1 2026

Latest Period

Q4 2025

Institutions Reporting

77

Shares (Excl. Options)

23,239,545

Price

$4.97

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Type / Class
Equity / Common Stock, par value $0.001 per share
Symbol
ACHV on Nasdaq
Shares outstanding
107,480,651
Price per share
$3.58
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
23,239,545
Total reported value
$115,291,318
% of total 13F portfolios
0%
Share change
+7,083,476
Value change
+$36,552,641
Number of holders
77
Price from insider filings
$3.58
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Quick Takeaways

  • ACHV - ACHIEVE LIFE SCIENCES, INC. - Common Stock, par value $0.001 per share is tracked under CUSIP 004468500.
  • 77 institutions reported positions in Q4 2025.
  • 10 significant owners is listed from Schedule 13D/13G reporting.

What Changed

  • Holder count moved from 77 to 15 between Q4 2025 and Q1 2026.
  • Reported value moved from $115,291,318 to $7,752,261.

Why This Matters

  • You can quickly see who holds this security, then open quarter and manager detail pages for full evidence.
  • 13F and Schedule 13D/13G sections are kept together so you can cross-check institutional and beneficial ownership context.

Source Evidence

Source: SEC Form 13F

Latest holder context comes from 77 institutions filings for Q4 2025.

Open SEC Evidence

Investment Quick Answers

What is CUSIP 004468500?
CUSIP 004468500 identifies ACHV - ACHIEVE LIFE SCIENCES, INC. - Common Stock, par value $0.001 per share in SEC 13F datasets.

Where can I see the latest institutional holders?
Review the Q4 2025 holders report and the ownership history table below.

Significant Owners of ACHIEVE LIFE SCIENCES, INC. - Common Stock, par value $0.001 per share (ACHV) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
TPG GP A, LLC 13% $40,440,170 13,755,160 TPG GP A, LLC 17 Apr 2025
venBio Global Strategic Fund V, L.P. 10% $31,567,712 10,737,317 venBio Global Strategic Fund V, L.P. 15 Apr 2026
Paradigm Biocapital Advisors LP 9.2% $29,116,913 9,903,712 Paradigm BioCapital Advisors LP 17 Apr 2026
Frazier Life Sciences Public Fund, L.P. 6.5% $19,479,817 6,625,788 Frazier Life Sciences Public Fund, L.P. 17 Apr 2026
FRANKLIN RESOURCES INC 12% -28% $31,654,889 -$11,286,105 6,369,193 -26% Franklin Resources, Inc. 31 Dec 2025
Venrock Healthcare Capital Partners III, L.P. 5.2% $16,176,068 5,502,064 Venrock Healthcare Capital Partners III, L.P. 17 Apr 2026
Alyeska Investment Group, L.P. 5.6% -43% $9,395,574 -$6,098,715 2,982,722 -39% Alyeska Investment Group, L.P. 30 Sep 2025
Contrarian Alpha, LP 4.9% $7,964,388 2,528,377 Parker Quillen 30 Sep 2025
VANGUARD GROUP INC 5% $4,086,493 1,717,014 The Vanguard Group 31 Mar 2025
BlackRock, Inc. 0.6% $711,220 314,699 BlackRock, Inc. 30 Jun 2025

As of 31 Dec 2025, 77 institutional investors reported holding 23,239,545 shares of ACHIEVE LIFE SCIENCES, INC. - Common Stock, par value $0.001 per share (ACHV). This represents 22% of the company’s total 107,480,651 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of ACHIEVE LIFE SCIENCES, INC. - Common Stock, par value $0.001 per share (ACHV) together control 20% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
FRANKLIN RESOURCES INC 4.1% 4,369,193 +18747% 0.01% $21,714,889
Propel Bio Management, LLC 3.5% 3,786,425 0% 16% $18,818,532
VANGUARD GROUP INC 2.3% 2,474,312 +0.51% 0% $12,297,331
MILLENNIUM MANAGEMENT LLC 1.3% 1,359,116 +472% 0% $6,754,807
Simplify Asset Management Inc. 1.1% 1,184,512 0% 0.1% $5,887,025
MARSHALL WACE, LLP 0.95% 1,019,281 +32% 0% $5,065,825
TWO SIGMA INVESTMENTS, LP 0.7% 748,616 +71% 0.01% $3,720,622
Nantahala Capital Management, LLC 0.6% 648,885 0% 0.19% $3,224,958
LPL Financial LLC 0.59% 633,148 +91% 0% $3,146,746
RAYMOND JAMES FINANCIAL INC 0.56% 599,679 +31% 0% $2,980,404
GEODE CAPITAL MANAGEMENT, LLC 0.56% 599,611 +18% 0% $2,981,591
SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.46% 496,350 +35% 0% $2,466,859
KVP Capital Advisors, LP 0.43% 462,355 0% 2.4% $2,297,904
GOLDMAN SACHS GROUP INC 0.42% 450,928 +101% 0% $2,241,112
BlackRock, Inc. 0.39% 419,133 +7.1% 0% $2,083,091
Pathstone Holdings, LLC 0.39% 416,667 -17% 0.01% $1,858,335
JANE STREET GROUP, LLC 0.36% 382,211 0% $1,899,588
UBS Group AG 0.27% 285,229 +260% 0% $1,417,588
Shay Capital LLC 0.22% 234,937 -19% 0.19% $1,167,637
STATE STREET CORP 0.22% 234,257 +6.3% 0% $1,164,257
NORTHERN TRUST CORP 0.21% 229,879 +4.8% 0% $1,142,499
683 Capital Management, LLC 0.2% 214,897 0.09% $1,068,038
TWO SIGMA ADVISERS, LP 0.2% 209,900 +90% 0% $1,043,203
BNP PARIBAS FINANCIAL MARKETS 0.16% 167,945 0% 0% $834,687
Squarepoint Ops LLC 0.15% 164,605 -56% 0% $818,087

Institutional Holders of ACHIEVE LIFE SCIENCES, INC. - Common Stock, par value $0.001 per share (ACHV) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2026 Q1 2,623,820 $7,752,261 +$769,629 $2.94 15
2025 Q4 23,239,545 $115,291,318 +$36,552,641 $4.97 77
2025 Q3 15,541,415 $48,917,159 -$26,338,868 $3.15 65
2025 Q2 26,238,674 $59,299,106 +$26,395,211 $2.26 64
2025 Q1 14,388,656 $38,412,610 -$6,420,566 $2.67 72
2024 Q4 16,340,748 $57,510,675 -$2,280,524 $3.52 70
2024 Q3 16,929,998 $81,217,159 +$2,394,591 $4.74 64
2024 Q2 12,513,128 $58,811,518 +$9,414,756 $4.70 54
2024 Q1 10,495,260 $47,701,835 +$35,368,247 $4.54 39
2023 Q4 2,727,493 $11,236,940 -$1,729,113 $4.12 29
2023 Q3 3,117,219 $13,403,691 -$2,279,792 $4.30 35
2023 Q2 3,562,232 $18,487,663 +$5,645,131 $5.19 38
2023 Q1 2,470,554 $16,600,668 +$3,392,110 $6.80 31
2022 Q4 1,999,698 $4,902,826 -$458,841 $2.45 27
2022 Q3 2,121,733 $7,001,230 +$176,107 $3.30 28
2022 Q2 2,043,015 $9,968,000 -$109,417 $4.88 31
2022 Q1 1,932,821 $14,633,000 -$2,149 $7.57 33
2021 Q4 1,918,795 $14,925,000 +$535,636 $7.78 26
2021 Q3 1,782,658 $15,149,000 -$1,185,059 $8.50 30
2021 Q2 1,948,272 $17,498,000 +$7,592,533 $8.98 28
2021 Q1 1,007,113 $11,662,000 +$6,322,912 $11.58 16
2020 Q4 493,003 $3,994,000 +$307,274 $8.10 14
2020 Q3 452,590 $3,789,000 +$3,789,000 $8.37 12
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