| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Third Rock Ventures IV, L.P. | 9.3% | -33% | $179,808,372 | -$64,304,000 | 4,473,958 | -26% | Third Rock Ventures IV, L.P. | 31 Dec 2025 |
| Frazier Life Sciences Public Fund, L.P. | 9% | +16% | $174,515,671 | +$39,762,017 | 4,342,266 | +30% | Frazier Life Sciences Public Fund, L.P. | 31 Dec 2025 |
| ARCH Venture Fund X, L.P. | 9.4% | $36,215,266 | 4,120,053 | ARCH Venture Fund X, L.P. | 31 Mar 2025 | |||
| Deep Track Capital, LP | 9% | +30% | $59,431,096 | +$13,927,661 | 3,948,910 | +31% | Deep Track Capital, LP | 30 Jun 2025 |
| JANUS HENDERSON GROUP PLC | 7.3% | +22% | $83,143,819 | +$15,075,261 | 3,206,472 | +22% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
| Matrix Capital Management Company, LP | 3.5% | -37% | $42,880,026 | -$21,586,725 | 1,653,684 | -33% | Matrix Capital Management Company, LP | 30 Sep 2025 |
| GV 2019, L.P. | 2.9% | -52% | $57,528,994 | -$42,419,680 | 1,388,583 | -42% | Alphabet Holdings LLC | 31 Dec 2025 |
| Foresite Capital Fund IV, L.P. | 1.4% | -70% | $15,790,022 | -$47,922,789 | 608,948 | -75% | James Tananbaum | 30 Sep 2025 |
As of 31 Dec 2025, 142 institutional investors reported holding 48,364,392 shares of Maze Therapeutics, Inc. - Common Stock - par value $0.001 per share (MAZE). This represents 100% of the company’s total 48,247,400 outstanding shares.
The largest institutional shareholders of Maze Therapeutics, Inc. - Common Stock - par value $0.001 per share (MAZE) together control 84% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 9.5% | 4,567,274 | 0% | 5.1% | $189,222,162 |
| TRV GP IV, LLC | 9.3% | 4,473,958 | -26% | 73% | $185,356,080 |
| Deep Track Capital, LP | 8.8% | 4,246,440 | +7.5% | 4% | $175,930,009 |
| ARCH Venture Management, LLC | 8.5% | 4,120,053 | 0% | 26% | $170,693,796 |
| JANUS HENDERSON GROUP PLC | 6.5% | 3,142,587 | +318% | 0.06% | $130,197,379 |
| BlackRock, Inc. | 4.7% | 2,287,155 | +74% | 0% | $94,756,831 |
| a16z Capital Management, L.L.C. | 3.5% | 1,702,225 | 0% | 4.5% | $70,523,182 |
| VANGUARD GROUP INC | 3.5% | 1,697,015 | +27% | 0% | $70,307,332 |
| VR ADVISER, LLC | 3.2% | 1,548,569 | +26% | 3.2% | $64,157,214 |
| Alphabet Inc. | 2.9% | 1,388,583 | -42% | 2.2% | $57,528,994 |
| General Catalyst Group Management, LLC | 2.1% | 1,035,910 | 0% | 19% | $42,917,751 |
| Woodline Partners LP | 2.1% | 1,035,229 | 0% | 0.17% | $42,889,537 |
| TRV GP V, LLC | 2% | 950,800 | 0% | 9.2% | $39,391,644 |
| Logos Global Management LP | 2% | 950,000 | -23% | 2.6% | $39,358,500 |
| Bellevue Group AG | 1.8% | 887,708 | 0.7% | $36,777,742 | |
| MARSHALL WACE, LLP | 1.8% | 847,472 | +9% | 0.03% | $35,110,765 |
| ArrowMark Colorado Holdings LLC | 1.6% | 767,383 | +41% | 0.7% | $31,792,678 |
| Casdin Capital, LLC | 1.6% | 758,857 | 0% | 2% | $31,439,446 |
| FMR LLC | 1.5% | 728,605 | +11% | 0% | $30,186,105 |
| Ikarian Capital, LLC | 1.3% | 644,680 | -13% | 3.5% | $26,709,093 |
| Caligan Partners LP | 1.1% | 550,191 | 2.1% | $22,794,413 | |
| STATE STREET CORP | 1.1% | 533,005 | +39% | 0% | $22,082,397 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.1% | 527,281 | +11% | 0% | $21,850,329 |
| Foresite Capital Management IV, LLC | 1.1% | 522,657 | 0% | 9.4% | $21,653,680 |
| Squadron Capital Management LLC | 1% | 490,000 | 0% | 9.1% | $20,300,700 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 48,364,392 | $2,003,586,016 | +$199,192,055 | $41.43 | 142 |
| 2025 Q3 | 42,970,633 | $1,114,223,528 | +$108,250,260 | $25.93 | 93 |
| 2025 Q2 | 38,836,437 | $476,719,891 | -$14,337,293 | $12.27 | 74 |
| 2025 Q1 | 40,038,674 | $441,393,439 | +$441,263,796 | $11.01 | 68 |