| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Third Rock Ventures IV, L.P. | 14% | $53,390,091 | 6,073,958 | Third Rock Ventures IV, L.P. | 31 Jan 2025 | |||
| ARCH Venture Fund X, L.P. | 9.4% | $36,215,266 | 4,120,053 | ARCH Venture Fund X, L.P. | 31 Mar 2025 | |||
| Deep Track Capital, LP | 9% | +30% | $59,431,096 | +$13,927,661 | 3,948,910 | +31% | Deep Track Capital, LP | 30 Jun 2025 |
| Frazier Life Sciences Public Fund, L.P. | 7.7% | -25% | $50,461,371 | -$16,531,281 | 3,352,915 | -25% | Frazier Life Sciences Public Fund, L.P. | 30 Jun 2025 |
| JANUS HENDERSON GROUP PLC | 7.3% | +22% | $83,143,819 | +$15,075,261 | 3,206,472 | +22% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
| GV 2019, L.P. | 5.5% | $21,205,620 | 2,412,471 | Alphabet Holdings LLC | 31 Mar 2025 | |||
| Matrix Capital Management Company, LP | 3.5% | -37% | $42,880,026 | -$21,586,725 | 1,653,684 | -33% | Matrix Capital Management Company, LP | 30 Sep 2025 |
| Foresite Capital Fund IV, L.P. | 1.4% | -70% | $15,790,022 | -$47,922,789 | 608,948 | -75% | James Tananbaum | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| TRV GP IV, LLC | 14% | 6,073,958 | 0% | 57% | $157,497,731 |
| Frazier Life Sciences Management, L.P. | 11% | 4,567,274 | -0% | 3.5% | $118,429,415 |
| ARCH Venture Management, LLC | 9.5% | 4,120,053 | 0% | 22% | $106,832,974 |
| Deep Track Capital, LP | 9.1% | 3,948,910 | 0% | 2.9% | $102,395,236 |
| Alphabet Inc. | 5.5% | 2,412,471 | 0% | 2.6% | $62,555,373 |
| a16z Capital Management, L.L.C. | 3.9% | 1,702,225 | 0% | 3.2% | $44,138,694 |
| Matrix Capital Management Company, LP | 3.8% | 1,653,684 | -33% | 40% | $42,880,026 |
| VANGUARD GROUP INC | 3.1% | 1,334,955 | +218% | 0% | $34,615,383 |
| BlackRock, Inc. | 3% | 1,316,016 | +114% | 0% | $34,124,295 |
| VR ADVISER, LLC | 2.8% | 1,230,769 | 1.8% | $31,913,840 | |
| Logos Global Management LP | 2.8% | 1,227,300 | +101% | 3.1% | $31,823,889 |
| General Catalyst Group Management, LLC | 2.4% | 1,035,910 | 0% | 0.88% | $26,861,146 |
| Woodline Partners LP | 2.4% | 1,035,229 | +10% | 0.13% | $26,843,488 |
| TRV GP V, LLC | 2.2% | 950,800 | 0% | 7% | $24,654,244 |
| MARSHALL WACE, LLP | 1.8% | 777,701 | +3868% | 0.02% | $20,165,786 |
| Casdin Capital, LLC | 1.7% | 758,857 | 0% | 1.6% | $19,677,162 |
| JANUS HENDERSON GROUP PLC | 1.7% | 751,874 | -46% | 0.01% | $19,488,574 |
| Ikarian Capital, LLC | 1.7% | 740,825 | +182% | 4.4% | $19,209,592 |
| FMR LLC | 1.5% | 655,614 | +18% | 0% | $17,000,071 |
| ArrowMark Colorado Holdings LLC | 1.3% | 545,132 | 0.26% | $14,135,273 | |
| Foresite Capital Management IV, LLC | 1.2% | 522,657 | -75% | 7.4% | $13,552,496 |
| BESSEMER GROUP INC | 1.1% | 481,790 | 0% | 0.02% | $12,493,000 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.1% | 473,549 | +105% | 0% | $12,281,796 |
| HHLR ADVISORS, LTD. | 1.1% | 457,535 | 0% | 0.29% | $11,863,883 |
| Balyasny Asset Management L.P. | 1% | 433,725 | 0.02% | $11,246,489 |