Latest Period
Q4 2025
Security Snapshot
Structure Therapeutics Inc. - Ordinary Shares, par value $0.0001 per share (GPCR) Institutional Ownership
CUSIP: 86366E106
13F Institutional Holders and Ownership History from Q1 2023 to Q1 2026
Institutions Reporting
197
Shares (Excl. Options)
65,776,439
Price
$69.55
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- Type / Class
- Equity / Ordinary Shares, par value $0.0001 per share
- Symbol
- GPCR on Nasdaq
- Shares outstanding
- 213,001,347
- Price per share
- $54.25
- All holders as of 31 Dec 2025
- Q4 2025
- Total 13F shares
- 65,776,439
- Total reported value
- $4,580,197,295
- % of total 13F portfolios
- 0.01%
- Share change
- +9,022,085
- Value change
- +$791,360,837
- Number of holders
- 197
- Price from insider filings
- $54.25
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors
Quick Takeaways
- GPCR - Structure Therapeutics Inc. - Ordinary Shares, par value $0.0001 per share is tracked under CUSIP 86366E106.
- 197 institutions reported positions in Q4 2025.
- 7 significant owners is listed from Schedule 13D/13G reporting.
What Changed
- Holder count moved from 197 to 26 between Q4 2025 and Q1 2026.
- Reported value moved from $4,580,197,295 to $117,984,792.
Why This Matters
- You can quickly see who holds this security, then open quarter and manager detail pages for full evidence.
- 13F and Schedule 13D/13G sections are kept together so you can cross-check institutional and beneficial ownership context.
Source Evidence
Source: SEC Form 13F
Open SEC Evidence
Latest holder context comes from 197 institutions filings for Q4 2025.
Investment Quick Answers
What is CUSIP 86366E106?
CUSIP 86366E106 identifies GPCR - Structure Therapeutics Inc. - Ordinary Shares, par value $0.0001 per share in SEC 13F datasets.
Where can I see the latest institutional holders?
Review the Q4 2025 holders report and the ownership history table below.
Next ownership checks
Use the next link that matches the question you still need to answer about this security.
- Latest 13F filings when you want to inspect fresh institutional portfolio moves.
- Latest Schedule 13D/13G reports when you need large-owner changes outside the 13F cycle.
- All institutional ownership pages to compare this security with other holder-history pages.
Recent Quarterly Holder Reports
Open recent reporting periods for CUSIP 86366E106:
Significant Owners of Structure Therapeutics Inc. - Ordinary Shares, par value $0.0001 per share (GPCR) based on Schedule 13D/G filings
| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 15% | +28% | $2,163,883,695 | +$776,609,280 | 31,112,634 | +56% | FMR LLC | 31 Dec 2025 |
| WELLINGTON MANAGEMENT GROUP LLP | 10% | -15% | $1,481,942,431 | +$50,941,729 | 21,365,952 | +3.6% | Wellington Management Group LLP | 31 Dec 2025 |
| Avoro Capital Advisors LLC | 9.4% | $454,066,620 | 16,216,665 | Avoro Capital Advisors LLC | 30 Sep 2025 | |||
| Deep Track Capital, LP | 6% | -20% | $855,579,599 | -$21,646,354 | 12,335,346 | -2.5% | Deep Track Capital, LP | 31 Dec 2025 |
| BIOTECHNOLOGY VALUE FUND L P | 4.9% | -12% | $723,914,898 | +$57,243,848 | 10,437,066 | +8.6% | BVF PARTNERS L P/IL | 31 Dec 2025 |
| Capital Research Global Investors | 3.8% | $168,218,991 | 6,492,435 | Capital Research Global Investors | 31 Mar 2025 | |||
| JANUS HENDERSON GROUP PLC | 7.7% | -3.8% | $124,567,128 | -$3,477,040 | 4,448,826 | -2.7% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
As of 31 Dec 2025, 197 institutional investors reported holding 65,776,439 shares of Structure Therapeutics Inc. - Ordinary Shares, par value $0.0001 per share (GPCR). This represents 31% of the company’s total 213,001,347 outstanding shares.
Top 25 Institutional Shareholders
The largest institutional shareholders of Structure Therapeutics Inc. - Ordinary Shares, par value $0.0001 per share (GPCR) together control 26% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 4.1% | 8,712,251 | +66% | 0.03% | $605,937,057 |
| WELLINGTON MANAGEMENT GROUP LLP | 3.3% | 7,121,984 | +25% | 0.09% | $495,333,988 |
| Avoro Capital Advisors LLC | 3.1% | 6,555,555 | +27% | 4.5% | $455,938,850 |
| JANUS HENDERSON GROUP PLC | 2.4% | 5,090,148 | +14% | 0.16% | $354,005,522 |
| Deep Track Capital, LP | 1.9% | 4,111,782 | -2.5% | 6.5% | $285,974,438 |
| BVF INC/IL | 1.6% | 3,479,022 | +8.6% | 8.1% | $241,965,980 |
| MORGAN STANLEY | 0.98% | 2,087,834 | +261% | 0.01% | $145,208,903 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0.78% | 1,671,138 | +477% | 0.01% | $116,228,000 |
| Driehaus Capital Management LLC | 0.77% | 1,642,444 | +88% | 0.78% | $114,231,980 |
| BAKER BROS. ADVISORS LP | 0.67% | 1,432,529 | -7.9% | 0.58% | $99,632,392 |
| PRINCIPAL FINANCIAL GROUP INC | 0.6% | 1,284,210 | +63% | 0.05% | $89,316,805 |
| Casdin Capital, LLC | 0.55% | 1,175,000 | -24% | 5.1% | $81,721,250 |
| ORBIMED ADVISORS LLC | 0.55% | 1,161,803 | +2% | 1.7% | $80,803,399 |
| Siren, L.L.C. | 0.51% | 1,078,698 | +5.1% | 2.2% | $75,023,446 |
| TCG Crossover Management, LLC | 0.43% | 920,857 | -13% | 2.1% | $64,045,604 |
| Capitolis Liquid Global Markets LLC | 0.41% | 878,300 | 0.36% | $61,085,765 | |
| FRANKLIN RESOURCES INC | 0.41% | 870,582 | +17% | 0.01% | $60,548,961 |
| ALLIANCEBERNSTEIN L.P. | 0.4% | 848,851 | +2772% | 0.02% | $59,037,587 |
| DEUTSCHE BANK AG\ | 0.39% | 841,162 | 0.02% | $58,502,817 | |
| CITADEL ADVISORS LLC | 0.36% | 772,518 | +74% | 0.04% | $53,728,627 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0.36% | 767,993 | +106% | 0.68% | $53,413,913 |
| Rock Springs Capital Management LP | 0.35% | 748,236 | -21% | 2.7% | $52,039,814 |
| Pacific Heights Asset Management LLC | 0.33% | 700,000 | 0% | 1.8% | $48,685,000 |
| Logos Global Management LP | 0.28% | 600,000 | -29% | 2.8% | $41,730,000 |
| AMERICAN CENTURY COMPANIES INC | 0.24% | 506,959 | +4.1% | 0.02% | $35,259,464 |
Institutional Holders of Structure Therapeutics Inc. - Ordinary Shares, par value $0.0001 per share (GPCR) across Reporting Periods
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2026 Q1 | 2,447,760 | $117,984,792 | +$9,223,054 | $48.20 | 26 |
| 2025 Q4 | 65,776,439 | $4,580,197,295 | +$791,360,837 | $69.55 | 197 |
| 2025 Q3 | 56,638,847 | $1,582,549,935 | +$86,587,271 | $28.00 | 155 |
| 2025 Q2 | 54,653,188 | $1,133,630,623 | -$12,998,783 | $20.74 | 172 |
| 2025 Q1 | 55,933,663 | $980,564,651 | -$97,541,400 | $17.31 | 150 |
| 2024 Q4 | 60,660,143 | $1,645,431,741 | -$123,990,833 | $27.12 | 162 |
| 2024 Q3 | 61,353,442 | $2,685,754,151 | +$108,882,886 | $43.89 | 160 |
| 2024 Q2 | 59,255,636 | $2,326,748,242 | +$609,713,327 | $39.27 | 164 |
| 2024 Q1 | 43,607,566 | $1,861,796,908 | +$49,174,094 | $42.86 | 119 |
| 2023 Q4 | 42,586,066 | $1,736,374,072 | +$365,354,803 | $40.76 | 121 |
| 2023 Q3 | 32,752,287 | $1,641,782,565 | +$750,250,715 | $50.42 | 83 |
| 2023 Q2 | 17,647,287 | $699,362,453 | +$105,685,176 | $41.57 | 48 |
| 2023 Q1 | 14,419,544 | $343,038,725 | +$343,038,726 | $23.79 | 38 |