Structure Therapeutics Inc. - Ordinary Shares, par value $0.0001 per share (GPCR) Institutional Ownership

13F Institutional Holders and Ownership History from Q1 2023 to Q4 2025

Type / Class
Equity / Ordinary Shares, par value $0.0001 per share
Symbol
GPCR on Nasdaq
Shares outstanding
213,001,347
Price per share
$89.05
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
65,727,618
Total reported value
$4,576,801,794
% of total 13F portfolios
0.01%
Share change
+9,022,085
Value change
+$791,360,837
Number of holders
195
Price from insider filings
$89.05
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Structure Therapeutics Inc. - Ordinary Shares, par value $0.0001 per share (GPCR) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
FMR LLC 15% +28% $2,163,883,695 +$776,609,280 31,112,634 +56% FMR LLC 31 Dec 2025
WELLINGTON MANAGEMENT GROUP LLP 10% -15% $1,481,942,431 +$50,941,729 21,365,952 +3.6% Wellington Management Group LLP 31 Dec 2025
Avoro Capital Advisors LLC 9.4% $454,066,620 16,216,665 Avoro Capital Advisors LLC 30 Sep 2025
Deep Track Capital, LP 6% -20% $855,579,599 -$21,646,354 12,335,346 -2.5% Deep Track Capital, LP 31 Dec 2025
BIOTECHNOLOGY VALUE FUND L P 4.9% -12% $723,914,898 +$57,243,848 10,437,066 +8.6% BVF PARTNERS L P/IL 31 Dec 2025
Capital Research Global Investors 3.8% $168,218,991 6,492,435 Capital Research Global Investors 31 Mar 2025
JANUS HENDERSON GROUP PLC 7.7% -3.8% $124,567,128 -$3,477,040 4,448,826 -2.7% JANUS HENDERSON GROUP PLC 30 Sep 2025

As of 31 Dec 2025, 195 institutional investors reported holding 65,727,618 shares of Structure Therapeutics Inc. - Ordinary Shares, par value $0.0001 per share (GPCR). This represents 31% of the company’s total 213,001,347 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of Structure Therapeutics Inc. - Ordinary Shares, par value $0.0001 per share (GPCR) together control 26% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
FMR LLC 4.1% 8,712,251 +66% 0.03% $605,937,057
WELLINGTON MANAGEMENT GROUP LLP 3.3% 7,121,984 +25% 0.09% $495,333,988
Avoro Capital Advisors LLC 3.1% 6,555,555 +27% 4.5% $455,938,850
JANUS HENDERSON GROUP PLC 2.4% 5,090,148 +14% 0.16% $354,005,522
Deep Track Capital, LP 1.9% 4,111,782 -2.5% 6.5% $285,974,438
BVF INC/IL 1.6% 3,479,022 +8.6% 8.1% $241,965,980
MORGAN STANLEY 0.98% 2,087,834 +261% 0.01% $145,208,903
PRICE T ROWE ASSOCIATES INC /MD/ 0.78% 1,671,138 +477% 0.01% $116,228,000
Driehaus Capital Management LLC 0.77% 1,642,444 +88% 0.78% $114,231,980
BAKER BROS. ADVISORS LP 0.67% 1,432,529 -7.9% 0.58% $99,632,392
PRINCIPAL FINANCIAL GROUP INC 0.6% 1,284,210 +63% 0.05% $89,316,805
Casdin Capital, LLC 0.55% 1,175,000 -24% 5.1% $81,721,250
ORBIMED ADVISORS LLC 0.55% 1,161,803 +2% 1.7% $80,803,399
Siren, L.L.C. 0.51% 1,078,698 +5.1% 2.2% $75,023,446
TCG Crossover Management, LLC 0.43% 920,857 -13% 2.1% $64,045,604
Capitolis Liquid Global Markets LLC 0.41% 878,300 0.36% $61,085,765
FRANKLIN RESOURCES INC 0.41% 870,582 +17% 0.01% $60,548,961
ALLIANCEBERNSTEIN L.P. 0.4% 848,851 +2772% 0.02% $59,037,587
DEUTSCHE BANK AG\ 0.39% 841,162 0.02% $58,502,817
CITADEL ADVISORS LLC 0.36% 772,518 +74% 0.04% $53,728,627
DEERFIELD MANAGEMENT COMPANY, L.P. 0.36% 767,993 +106% 0.68% $53,413,913
Rock Springs Capital Management LP 0.35% 748,236 -21% 2.7% $52,039,814
Pacific Heights Asset Management LLC 0.33% 700,000 0% 1.8% $48,685,000
Logos Global Management LP 0.28% 600,000 -29% 2.8% $41,730,000
AMERICAN CENTURY COMPANIES INC 0.24% 506,959 +4.1% 0.02% $35,259,464

Institutional Holders of Structure Therapeutics Inc. - Ordinary Shares, par value $0.0001 per share (GPCR) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 65,727,618 $4,576,801,794 +$791,360,837 $69.55 195
2025 Q3 56,638,847 $1,582,549,935 +$86,587,271 $28.00 155
2025 Q2 54,653,188 $1,133,630,623 -$12,998,783 $20.74 172
2025 Q1 55,933,663 $980,564,651 -$97,541,400 $17.31 150
2024 Q4 60,660,143 $1,645,431,741 -$123,990,833 $27.12 162
2024 Q3 61,353,442 $2,685,754,151 +$108,882,886 $43.89 160
2024 Q2 59,255,636 $2,326,748,242 +$609,713,327 $39.27 164
2024 Q1 43,607,566 $1,861,796,908 +$49,174,094 $42.86 119
2023 Q4 42,586,066 $1,736,374,072 +$365,354,803 $40.76 121
2023 Q3 32,752,287 $1,641,782,565 +$750,250,715 $50.42 83
2023 Q2 17,647,287 $699,362,453 +$105,685,176 $41.57 48
2023 Q1 14,419,544 $343,038,725 +$343,038,726 $23.79 38