| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 12% | +20% | $577,681,944 | +$99,790,236 | 20,631,498 | +21% | Wellington Management Group LLP | 31 Oct 2025 |
| FMR LLC | 12% | $373,796,154 | 19,946,433 | FMR LLC | 30 Jun 2025 | |||
| Avoro Capital Advisors LLC | 9.4% | $454,066,620 | 16,216,665 | Avoro Capital Advisors LLC | 30 Sep 2025 | |||
| Deep Track Capital, LP | 7.3% | -18% | $354,128,124 | -$77,120,904 | 12,647,433 | -18% | Deep Track Capital, LP | 30 Sep 2025 |
| BIOTECHNOLOGY VALUE FUND L P | 5.6% | $171,089,168 | 9,611,751 | BVF PARTNERS L P/IL | 11 Aug 2025 | |||
| Capital Research Global Investors | 3.8% | $168,218,991 | 6,492,435 | Capital Research Global Investors | 31 Mar 2025 | |||
| JANUS HENDERSON GROUP PLC | 7.7% | -3.8% | $124,567,128 | -$3,477,040 | 4,448,826 | -2.7% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 3.3% | 5,689,187 | -17% | 0.03% | $159,297,236 |
| FMR LLC | 3% | 5,250,368 | +6.8% | 0.01% | $147,010,304 |
| Avoro Capital Advisors LLC | 3% | 5,155,555 | 1.9% | $144,355,540 | |
| JANUS HENDERSON GROUP PLC | 2.6% | 4,448,826 | -2.7% | 0.06% | $124,603,170 |
| Deep Track Capital, LP | 2.4% | 4,215,811 | -18% | 3.3% | $118,042,708 |
| BVF INC/IL | 1.9% | 3,203,917 | +81% | 3.6% | $89,709,676 |
| BAKER BROS. ADVISORS LP | 0.9% | 1,556,109 | -38% | 0.31% | $43,571,052 |
| Casdin Capital, LLC | 0.9% | 1,555,000 | +27% | 3.6% | $43,540,000 |
| RA CAPITAL MANAGEMENT, L.P. | 0.88% | 1,517,418 | 0% | 0.52% | $42,487,704 |
| MILLENNIUM MANAGEMENT LLC | 0.74% | 1,274,551 | +4.5% | 0.03% | $35,687,428 |
| AMERIPRISE FINANCIAL INC | 0.71% | 1,224,144 | -23% | 0.01% | $34,276,032 |
| ORBIMED ADVISORS LLC | 0.66% | 1,139,300 | -5% | 0.77% | $31,900,400 |
| TCG Crossover Management, LLC | 0.62% | 1,063,000 | 0% | 1.5% | $29,764,000 |
| Siren, L.L.C. | 0.59% | 1,026,811 | 1.1% | $28,750,708 | |
| Rock Springs Capital Management LP | 0.55% | 951,154 | -16% | 1.6% | $26,632,312 |
| Driehaus Capital Management LLC | 0.51% | 873,504 | +30% | 0.18% | $24,458,112 |
| Logos Global Management LP | 0.49% | 850,000 | 0% | 2.4% | $23,800,000 |
| PRINCIPAL FINANCIAL GROUP INC | 0.46% | 787,484 | -7.7% | 0.01% | $22,049,552 |
| FRANKLIN RESOURCES INC | 0.43% | 745,734 | +0.53% | 0.01% | $20,880,551 |
| Pacific Heights Asset Management LLC | 0.41% | 700,000 | +52% | 0.87% | $19,600,000 |
| Catalio Capital Management, LP | 0.38% | 651,810 | -2.8% | 3.4% | $18,250,680 |
| Aberdeen Group plc | 0.34% | 586,869 | +46% | 0.03% | $16,432,332 |
| MORGAN STANLEY | 0.33% | 577,741 | -37% | 0% | $16,176,758 |
| GOLDMAN SACHS GROUP INC | 0.29% | 504,396 | +129% | 0% | $14,123,088 |
| AMERICAN CENTURY COMPANIES INC | 0.28% | 486,786 | -0.9% | 0.01% | $13,630,183 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 21,277 | $1,480,092 | -$1,339,015 | $69.55 | 4 |
| 2025 Q3 | 56,638,847 | $1,582,549,935 | +$86,587,271 | $28.00 | 155 |
| 2025 Q2 | 54,653,188 | $1,133,630,623 | -$12,998,783 | $20.74 | 172 |
| 2025 Q1 | 55,933,663 | $980,564,651 | -$97,541,400 | $17.31 | 150 |
| 2024 Q4 | 60,660,143 | $1,645,431,741 | -$123,990,833 | $27.12 | 162 |
| 2024 Q3 | 61,353,442 | $2,685,754,151 | +$108,882,886 | $43.89 | 160 |
| 2024 Q2 | 59,255,636 | $2,326,748,242 | +$609,713,327 | $39.27 | 164 |
| 2024 Q1 | 43,607,566 | $1,861,796,908 | +$49,174,094 | $42.86 | 119 |
| 2023 Q4 | 42,586,066 | $1,736,374,072 | +$365,354,803 | $40.76 | 121 |
| 2023 Q3 | 32,752,287 | $1,641,782,565 | +$750,250,715 | $50.42 | 83 |
| 2023 Q2 | 17,647,287 | $699,362,453 | +$105,685,176 | $41.57 | 48 |
| 2023 Q1 | 14,419,544 | $343,038,725 | +$343,038,726 | $23.79 | 38 |