Latest Period
Q1 2026
Security Snapshot
Praxis Precision Medicines, Inc. - Common Stock, par value $0.0001 per share (PRAX) Institutional Ownership
CUSIP: 74006W207
13F Institutional Holders and Ownership History from Q4 2023 to Q1 2026
Institutions Reporting
286
Shares (Excl. Options)
31,790,708
Price
$322.19
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- Security type / class
- Equity / Common Stock, par value $0.0001 per share
- Symbol
- PRAX on Nasdaq
- All holders as of 31 Mar 2026
- Q1 2026
- Total 13F shares
- 31,790,708
- Total 13F value
- $10,235,783,925
- Portfolio coverage rank
- 0.02%
- Share change
- +1,459,934
- Value change
- +$502,335,027
- Number of holders
- 286
- Shares outstanding
- 27,828,540
- SEC-reported price per share
- $346.84
- Insider filing price
- $346.84
Latest holder snapshot
5 signals
Issuer context
Names, identifiers, and filing context for this profile.
3 identity fields
13F Shares, Excluding Options vs Price
13F Value, Excluding Options
Total Investors
Key facts
- PRAX - Praxis Precision Medicines, Inc. - Common Stock, par value $0.0001 per share is tracked under CUSIP 74006W207.
- 286 institutions reported positions in Q1 2026.
- 13 significant owners is listed from Schedule 13D/13G reporting.
Change
- Holder count moved from 248 to 286 between Q4 2025 and Q1 2026.
- SEC-reported value moved from $8,685,917,153 to $10,235,783,925.
Research use
- You can quickly see who holds this security, then open quarter and manager detail pages for full evidence.
- 13F and Schedule 13D/13G sections are kept together so you can cross-check institutional and beneficial ownership context.
Evidence
Source: SEC Form 13F
Open SEC evidence
Latest holder context comes from 286 institutions filings for Q1 2026.
Security key
74006W207
Latest holder period
Q1 2026
13F holders
286
13D/G owners
13
CIK / CUSIP context first
Open Q1 2026 holders
PRAX full holder history
Praxis Precision Medicines, Inc. SEC filings
Praxis Precision Medicines, Inc. company facts
Praxis Precision Medicines, Inc. insider transactions
Broader feeds
Recent Quarterly Holder Reports
Open recent reporting periods for CUSIP 74006W207:
13D/G owners
Significant owners
Large-stake holder rows connected to Schedule 13D/G evidence.
Rows
13
Security
PRAX
| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 12% | -0.83% | $146,484,527 | +$12,214,062 | 2,763,859 | +9.1% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
| ORBIS INVESTMENT MANAGEMENT LTD | 8.9% | +78% | $795,297,984 | +$391,731,490 | 2,468,413 | +97% | ORBIS INVESTMENT MANAGEMENT LTD | 31 Mar 2026 |
| FMR LLC | 7.7% | +46% | $694,752,222 | +$258,740,479 | 2,156,343 | +59% | FMR LLC | 31 Mar 2026 |
| PERCEPTIVE ADVISORS LLC | 7.2% | +7.3% | $575,742,162 | +$182,728,171 | 1,995,986 | +46% | Perceptive Advisors LLC | 31 Dec 2025 |
| BAKER BROS. ADVISORS LP | 6.3% | $564,862,864 | 1,753,198 | Baker Bros. Advisors LP | 31 Mar 2026 | |||
| VANGUARD CAPITAL MANAGEMENT LLC | 5.1% | $457,291,677 | 1,419,323 | Vanguard Capital Management | 31 Mar 2026 | |||
| Venrock Healthcare Capital Partners III, L.P. | 4.9% | -20% | $37,813,688 | -$6,466,960 | 1,016,497 | -15% | Venrock Healthcare Capital Partners III, L.P. | 31 Mar 2025 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4.8% | $53,187,885 | 1,003,545 | T. Rowe Price Associates, Inc. | 30 Sep 2025 | |||
| Cormorant Asset Management, LP | 4% | -46% | $53,000,000 | -$33,125,000 | 1,000,000 | -38% | Cormorant Asset Management, LP | 30 Sep 2025 |
| Soleus Capital Master Fund, L.P. | 4.6% | -8% | $40,651,514 | -$2,144,555 | 966,740 | -5% | Soleus Capital Master Fund, L.P. | 30 Jun 2025 |
| Adage Capital Management, L.P. | 3.8% | -29% | $278,444,535 | -$98,033,194 | 965,313 | -26% | Adage Capital Management, L.P. | 31 Dec 2025 |
| Capital Research Global Investors | 4.2% | $31,759,351 | 853,746 | Capital Research Global Investors | 31 Mar 2025 | |||
| MORGAN STANLEY | 2.9% | -55% | $32,752,940 | -$28,575,480 | 617,980 | -47% | Morgan Stanley | 30 Sep 2025 |
As of 31 Mar 2026, 286 institutional investors reported holding 31,790,708 shares of Praxis Precision Medicines, Inc. - Common Stock, par value $0.0001 per share (PRAX). This represents 114% of the company’s total 27,828,540 outstanding shares.
13F concentration
Top 25 institutional shareholders
Largest 13F positions for this security by reported shares and value.
Top holder share
94%
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 12% | 3,458,863 | +6.8% | 0.53% | $1,113,513,848 |
| Orbis Allan Gray Ltd | 8.9% | 2,472,480 | +97% | 3.4% | $796,608,331 |
| BlackRock, Inc. | 8.4% | 2,324,929 | +12% | 0.01% | $749,068,873 |
| FMR LLC | 7.8% | 2,160,943 | +59% | 0.04% | $696,234,295 |
| PERCEPTIVE ADVISORS LLC | 7.3% | 2,035,986 | +2% | 13% | $655,974,329 |
| BAKER BROS. ADVISORS LP | 6.3% | 1,753,198 | +56% | 3.2% | $564,862,864 |
| VANGUARD CAPITAL MANAGEMENT LLC | 4.4% | 1,221,944 | 0% | 0.01% | $393,698,137 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3.5% | 963,351 | +6.6% | 3.7% | $310,382,059 |
| Driehaus Capital Management LLC | 3.4% | 949,225 | +1.7% | 2.2% | $305,830,803 |
| Cormorant Asset Management, LP | 3.2% | 885,500 | -6.8% | 14% | $285,299,245 |
| STATE STREET CORP | 3.2% | 884,238 | +0.23% | 0.01% | $284,892,641 |
| MORGAN STANLEY | 3% | 833,491 | -6.3% | 0.02% | $268,542,583 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2.9% | 815,739 | -15% | 0.41% | $262,822,948 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2.7% | 756,748 | 0% | 0.01% | $243,816,638 |
| GOLDMAN SACHS GROUP INC | 2.6% | 710,734 | -0.76% | 0.03% | $228,991,387 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.3% | 650,904 | +16% | 0.01% | $209,753,715 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.3% | 630,852 | -20% | 0.02% | $203,255,000 |
| BANK OF AMERICA CORP /DE/ | 1.9% | 534,604 | +2.3% | 0.01% | $172,244,063 |
| RA CAPITAL MANAGEMENT, L.P. | 1.3% | 373,787 | 0% | 1.3% | $120,430,434 |
| Hood River Capital Management LLC | 1.3% | 358,618 | +24% | 1.2% | $115,543,133 |
| Vivo Capital, LLC | 1.2% | 338,895 | +3% | 9.1% | $109,188,580 |
| Soleus Capital Management, L.P. | 1.2% | 330,517 | -8.9% | 4.3% | $106,489,272 |
| Pictet Asset Management Holding SA | 1% | 286,644 | +19% | 0.1% | $91,427,530 |
| Logos Global Management LP | 1% | 285,000 | -24% | 4.7% | $91,824,150 |
| FRANKLIN RESOURCES INC | 0.99% | 276,123 | -22% | 0.02% | $88,964,185 |
Quarter history
Institutional holders across reporting periods
Holder count, reported shares/value, and median price by quarter.
Periods
10
Latest
Q1 2026
Rows shown
1-10 of 10
| Period | 13F Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2026 Q1 | 31,790,708 | $10,235,783,925 | +$502,335,027 | $322.19 | 286 |
| 2025 Q4 | 29,469,044 | $8,685,917,153 | +$1,516,158,099 | $294.74 | 248 |
| 2025 Q3 | 24,666,145 | $1,307,300,657 | +$38,898,368 | $53.00 | 150 |
| 2025 Q2 | 24,151,627 | $1,015,573,040 | +$43,479,424 | $42.05 | 141 |
| 2025 Q1 | 23,362,159 | $886,031,367 | +$1,335,704 | $37.87 | 147 |
| 2024 Q4 | 21,720,756 | $1,671,718,000 | +$223,523,316 | $76.96 | 160 |
| 2024 Q3 | 18,868,572 | $1,091,231,093 | +$44,014,289 | $57.54 | 132 |
| 2024 Q2 | 18,424,832 | $762,133,327 | +$67,529,667 | $41.36 | 113 |
| 2024 Q1 | 15,918,361 | $971,295,549 | +$514,747,070 | $61.02 | 110 |
| 2023 Q4 | 7,555,380 | $168,332,336 | +$168,332,336 | $22.28 | 57 |