Latest Period
Q4 2025
- Info
- Insider Trading
- Financials
- Holders
Security Snapshot
Praxis Precision Medicines, Inc. - Common Stock (PRAX) Institutional Ownership
CUSIP: 74006W207
13F Institutional Holders and Ownership History from Q4 2023 to Q1 2026
Institutions Reporting
247
Shares (Excl. Options)
29,469,040
Price
$294.74
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- Type / Class
- Equity / Common Stock
- Symbol
- PRAX on Nasdaq
- Shares outstanding
- 25,726,377
- Price per share
- $322.19
- All holders as of 31 Dec 2025
- Q4 2025
- Total 13F shares
- 29,469,040
- Total reported value
- $8,685,915,974
- % of total 13F portfolios
- 0.02%
- Share change
- +4,707,059
- Value change
- +$1,516,157,215
- Number of holders
- 247
- Price from insider filings
- $322.19
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors
Quick Takeaways
- PRAX - Praxis Precision Medicines, Inc. - Common Stock is tracked under CUSIP 74006W207.
- 247 institutions reported positions in Q4 2025.
- 12 significant owners is listed from Schedule 13D/13G reporting.
What Changed
- Holder count moved from 247 to 12 between Q4 2025 and Q1 2026.
- Reported value moved from $8,685,915,974 to $9,475,930.
Why This Matters
- You can quickly see who holds this security, then open quarter and manager detail pages for full evidence.
- 13F and Schedule 13D/13G sections are kept together so you can cross-check institutional and beneficial ownership context.
Source Evidence
Source: SEC Form 13F
Open SEC Evidence
Latest holder context comes from 247 institutions filings for Q4 2025.
Investment Quick Answers
What is CUSIP 74006W207?
CUSIP 74006W207 identifies PRAX - Praxis Precision Medicines, Inc. - Common Stock in SEC 13F datasets.
Where can I see the latest institutional holders?
Review the Q4 2025 holders report and the ownership history table below.
Continue With The Right Next Step
- Latest 13F filings - identify new institutional portfolio moves.
- Latest Schedule 13D/13G reports - cross-check beneficial ownership events.
- All institutional ownership pages - compare nearby CUSIPs and holder concentration.
Recent Quarterly Holder Reports
Open recent reporting periods for CUSIP 74006W207:
Significant Owners of Praxis Precision Medicines, Inc. - Common Stock (PRAX) based on Schedule 13D/G filings
| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 12% | -0.83% | $146,484,527 | +$12,214,062 | 2,763,859 | +9.1% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
| PERCEPTIVE ADVISORS LLC | 7.2% | +7.3% | $575,742,162 | +$182,728,171 | 1,995,986 | +46% | Perceptive Advisors LLC | 31 Dec 2025 |
| Point72 Asset Management, L.P. | 6.1% | -35% | $452,667,181 | -$145,274,958 | 1,569,309 | -24% | Steven A. Cohen | 31 Dec 2025 |
| FMR LLC | 5.4% | $398,864,288 | 1,353,275 | FMR LLC | 31 Dec 2025 | |||
| ORBIS INVESTMENT MANAGEMENT LTD | 5% | $361,304,682 | 1,252,573 | ORBIS INVESTMENT MANAGEMENT LTD | 31 Dec 2025 | |||
| Venrock Healthcare Capital Partners III, L.P. | 4.9% | -20% | $37,813,688 | -$6,466,960 | 1,016,497 | -15% | Venrock Healthcare Capital Partners III, L.P. | 31 Mar 2025 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4.8% | $53,187,885 | 1,003,545 | T. Rowe Price Associates, Inc. | 30 Sep 2025 | |||
| Cormorant Asset Management, LP | 4% | -46% | $53,000,000 | -$33,125,000 | 1,000,000 | -38% | Cormorant Asset Management, LP | 30 Sep 2025 |
| Soleus Capital Master Fund, L.P. | 4.6% | -8% | $40,651,514 | -$2,144,555 | 966,740 | -5% | Soleus Capital Master Fund, L.P. | 30 Jun 2025 |
| Adage Capital Management, L.P. | 3.8% | -29% | $278,444,535 | -$98,033,194 | 965,313 | -26% | Adage Capital Management, L.P. | 31 Dec 2025 |
| Capital Research Global Investors | 4.2% | $31,759,351 | 853,746 | Capital Research Global Investors | 31 Mar 2025 | |||
| MORGAN STANLEY | 2.9% | -55% | $32,752,940 | -$28,575,480 | 617,980 | -47% | Morgan Stanley | 30 Sep 2025 |
As of 31 Dec 2025, 247 institutional investors reported holding 29,469,040 shares of Praxis Precision Medicines, Inc. - Common Stock (PRAX). This represents 115% of the company’s total 25,726,377 outstanding shares.
Top 25 Institutional Shareholders
The largest institutional shareholders of Praxis Precision Medicines, Inc. - Common Stock (PRAX) together control 93% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 13% | 3,240,086 | +17% | 0.43% | $954,833,974 |
| BlackRock, Inc. | 8.1% | 2,078,500 | +15% | 0.01% | $612,617,092 |
| PERCEPTIVE ADVISORS LLC | 7.8% | 1,995,986 | +28% | 11% | $588,296,914 |
| VANGUARD GROUP INC | 5.7% | 1,460,933 | +15% | 0.01% | $430,595,392 |
| FMR LLC | 5.3% | 1,358,675 | +3044% | 0.02% | $400,455,884 |
| Orbis Allan Gray Ltd | 4.9% | 1,255,162 | 1.6% | $369,946,448 | |
| BAKER BROS. ADVISORS LP | 4.4% | 1,126,488 | +63% | 1.9% | $332,021,073 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3.8% | 965,313 | -59% | 0.43% | $284,516,354 |
| Cormorant Asset Management, LP | 3.7% | 950,000 | -5% | 16% | $280,003,000 |
| Driehaus Capital Management LLC | 3.6% | 933,061 | +86% | 1.9% | $275,010,399 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3.5% | 903,351 | +7.4% | 3.4% | $266,253,674 |
| MORGAN STANLEY | 3.5% | 889,889 | +38% | 0.02% | $262,286,289 |
| STATE STREET CORP | 3.4% | 882,215 | -2.7% | 0.01% | $260,024,049 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.1% | 785,987 | -22% | 0.02% | $231,662,000 |
| GOLDMAN SACHS GROUP INC | 2.8% | 716,184 | +21% | 0.03% | $211,088,072 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.2% | 562,379 | +23% | 0.01% | $165,783,193 |
| BARCLAYS PLC | 2.1% | 530,751 | +593% | 0.06% | $156,433,549 |
| BANK OF AMERICA CORP /DE/ | 2% | 522,763 | +8.3% | 0.01% | $154,079,168 |
| Point72 Asset Management, L.P. | 1.9% | 492,346 | -67% | 0.23% | $145,114,060 |
| Assenagon Asset Management S.A. | 1.6% | 408,787 | -0.24% | 0.18% | $120,485,880 |
| Logos Global Management LP | 1.5% | 375,000 | +200% | 7.4% | $110,527,500 |
| RA CAPITAL MANAGEMENT, L.P. | 1.5% | 373,787 | 1.1% | $110,169,980 | |
| Soleus Capital Management, L.P. | 1.4% | 362,966 | -58% | 4.5% | $106,980,599 |
| FRANKLIN RESOURCES INC | 1.4% | 356,074 | +13% | 0.03% | $104,949,253 |
| Vivo Capital, LLC | 1.3% | 328,895 | +65% | 6.3% | $96,938,512 |
Institutional Holders of Praxis Precision Medicines, Inc. - Common Stock (PRAX) across Reporting Periods
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2026 Q1 | 29,442 | $9,475,930 | -$1,631,143 | $322.19 | 12 |
| 2025 Q4 | 29,469,040 | $8,685,915,974 | +$1,516,157,215 | $294.74 | 247 |
| 2025 Q3 | 24,666,145 | $1,307,300,657 | +$38,898,368 | $53.00 | 150 |
| 2025 Q2 | 24,151,627 | $1,015,573,040 | +$43,479,424 | $42.05 | 141 |
| 2025 Q1 | 23,362,159 | $886,031,367 | +$1,335,704 | $37.87 | 147 |
| 2024 Q4 | 21,720,756 | $1,671,718,000 | +$223,523,316 | $76.96 | 160 |
| 2024 Q3 | 18,868,572 | $1,091,231,093 | +$44,014,289 | $57.54 | 132 |
| 2024 Q2 | 18,424,832 | $762,133,327 | +$67,529,667 | $41.36 | 113 |
| 2024 Q1 | 15,918,361 | $971,295,549 | +$514,747,070 | $61.02 | 110 |
| 2023 Q4 | 7,555,380 | $168,332,336 | +$168,332,336 | $22.28 | 57 |