| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 12.3% | -0.83% | $146M | $12.2M | 2.76M | +9.1% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
| Point72 Asset Management, L.P. | 9.6% | +32.9% | $110M | $28.7M | 2.07M | +35.4% | Steven A. Cohen | 30 Sep 2025 |
| PERCEPTIVE ADVISORS LLC | 6.69% | +37.8% | $57.3M | $16M | 1.36M | +38.9% | Perceptive Advisors LLC | 15 Jul 2025 |
| Adage Capital Management, L.P. | 5.29% | -54.5% | $69.2M | -$56.7M | 1.31M | -45% | Adage Capital Management, L.P. | 31 Oct 2025 |
| Venrock Healthcare Capital Partners III, L.P. | 4.9% | -20% | $37.8M | -$6.47M | 1.02M | -14.6% | Venrock Healthcare Capital Partners III, L.P. | 31 Mar 2025 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4.8% | $53.2M | 1M | T. Rowe Price Associates, Inc. | 30 Sep 2025 | |||
| Cormorant Asset Management, LP | 4% | -46.5% | $53M | -$33.1M | 1M | -38.5% | Cormorant Asset Management, LP | 30 Sep 2025 |
| Soleus Capital Master Fund, L.P. | 4.6% | -8% | $40.7M | -$2.14M | 967K | -5.01% | Soleus Capital Master Fund, L.P. | 30 Jun 2025 |
| Capital Research Global Investors | 4.2% | $31.8M | 854K | Capital Research Global Investors | 31 Mar 2025 | |||
| MORGAN STANLEY | 2.9% | -55% | $32.8M | -$28.6M | 618K | -46.6% | Morgan Stanley | 30 Sep 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 24.7M | $1.31B | +$38.9M | $53.00 | 149 |
| 2025 Q2 | 24.2M | $1.02B | +$43.5M | $42.05 | 141 |
| 2025 Q1 | 23.4M | $886M | +$1.34M | $37.87 | 147 |
| 2024 Q4 | 21.7M | $1.67B | +$224M | $76.96 | 160 |
| 2024 Q3 | 18.9M | $1.09B | +$44M | $57.54 | 132 |
| 2024 Q2 | 18.4M | $762M | +$67.5M | $41.36 | 113 |
| 2024 Q1 | 15.9M | $971M | +$515M | $61.02 | 110 |
| 2023 Q4 | 7.56M | $168M | +$168M | $22.28 | 57 |