| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| GENERAL ATLANTIC, L.P. | 8.4% | $278,656,049 | 6,796,489 | General Atlantic, L.P. | 31 Mar 2025 | |||
| JANUS HENDERSON GROUP PLC | 7.9% | -6.7% | $298,188,881 | -$21,757,757 | 6,280,305 | -6.8% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
| RTW INVESTMENTS, LP | 7.3% | -25% | $304,707,219 | -$51,180,398 | 5,873,308 | -14% | RTW Investments, LP | 30 Jun 2025 |
| Deep Track Capital, LP | 5.5% | $208,910,680 | 4,400,000 | Deep Track Capital, LP | 30 Sep 2025 | |||
| WELLINGTON MANAGEMENT GROUP LLP | 5.3% | +25% | $201,878,360 | +$39,974,124 | 4,251,861 | +25% | Wellington Management Group LLP | 30 Sep 2025 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4.8% | $180,902,408 | 3,810,076 | T. Rowe Price Associates, Inc. | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 7.9% | 6,280,305 | -6.8% | 0.14% | $298,242,505 |
| GENERAL ATLANTIC, L.P. | 7.2% | 5,733,989 | 0% | 8.2% | $272,249,798 |
| BlackRock, Inc. | 7.2% | 5,702,634 | -1.3% | 0% | $270,761,064 |
| RTW INVESTMENTS, LP | 6.9% | 5,477,561 | 0% | 3.2% | $260,074,596 |
| VANGUARD GROUP INC | 5.7% | 4,526,920 | -0.06% | 0% | $214,938,161 |
| WELLINGTON MANAGEMENT GROUP LLP | 5.4% | 4,251,861 | +25% | 0.04% | $201,878,361 |
| Deep Track Capital, LP | 5% | 4,000,978 | +31% | 5.3% | $189,966,435 |
| Avoro Capital Advisors LLC | 5% | 3,955,555 | +13% | 2.4% | $187,809,751 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4.8% | 3,809,859 | -16% | 0.02% | $180,893,000 |
| STATE STREET CORP | 4.3% | 3,414,306 | +24% | 0.01% | $162,111,249 |
| Bellevue Group AG | 3% | 2,389,314 | +20% | 2.4% | $113,444,628 |
| ALKEON CAPITAL MANAGEMENT LLC | 2.3% | 1,850,934 | 0% | 0.4% | $87,882,346 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.2% | 1,785,586 | +3.7% | 0.01% | $84,792,838 |
| ALLIANCEBERNSTEIN L.P. | 2.1% | 1,689,629 | +10% | 0.03% | $80,223,585 |
| Point72 Asset Management, L.P. | 2.1% | 1,663,339 | -39% | 0.17% | $78,975,351 |
| BANK OF AMERICA CORP /DE/ | 1.6% | 1,297,438 | -1.7% | 0% | $61,602,356 |
| MARSHALL WACE, LLP | 1.5% | 1,217,044 | -14% | 0.06% | $57,785,250 |
| Logos Global Management LP | 1.5% | 1,200,000 | 0% | 5.6% | $56,976,000 |
| PERCEPTIVE ADVISORS LLC | 1.4% | 1,135,766 | +24% | 1.6% | $53,926,170 |
| FMR LLC | 1.4% | 1,079,657 | +16% | 0% | $51,262,104 |
| Polar Capital Holdings Plc | 1.3% | 1,058,776 | 0.24% | $50,270,684 | |
| Holocene Advisors, LP | 1.3% | 1,055,186 | -1.9% | 0.12% | $50,100,231 |
| Pictet Asset Management Holding SA | 1.2% | 926,441 | -6.1% | 0.04% | $43,997,202 |
| GOLDMAN SACHS GROUP INC | 1.1% | 855,766 | +12% | 0.01% | $40,631,770 |
| DIMENSIONAL FUND ADVISORS LP | 1% | 810,568 | +41% | 0.01% | $38,486,653 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 0 | $0 | -$858,331 | 0 | |
| 2025 Q3 | 91,445,783 | $4,342,086,695 | -$45,117,892 | $47.48 | 259 |
| 2025 Q2 | 92,131,681 | $4,916,497,064 | +$352,115,121 | $53.36 | 253 |
| 2025 Q1 | 86,154,634 | $3,503,843,061 | +$531,433,647 | $40.48 | 238 |
| 2024 Q4 | 74,174,925 | $2,063,406,098 | -$8,506,883 | $27.82 | 188 |
| 2024 Q3 | 73,002,070 | $2,094,264,742 | +$38,454,830 | $28.69 | 167 |
| 2024 Q2 | 71,810,586 | $1,684,723,283 | -$32,810,693 | $23.46 | 152 |
| 2024 Q1 | 73,087,900 | $1,845,988,959 | +$363,844,050 | $25.26 | 171 |
| 2023 Q4 | 58,426,478 | $1,364,286,476 | -$103,406,827 | $23.35 | 153 |
| 2023 Q3 | 56,757,185 | $2,870,716,263 | +$69,098,588 | $50.58 | 178 |
| 2023 Q2 | 56,372,656 | $2,631,606,875 | +$394,199,729 | $46.69 | 156 |
| 2023 Q1 | 48,070,649 | $1,839,011,256 | -$64,149,034 | $38.26 | 155 |
| 2022 Q4 | 48,581,649 | $2,661,931,733 | +$138,143,044 | $54.80 | 159 |
| 2022 Q3 | 46,589,695 | $1,586,331,269 | +$490,029,839 | $34.05 | 142 |
| 2022 Q2 | 34,862,359 | $329,587,739 | -$12,722,696 | $9.45 | 107 |
| 2022 Q1 | 35,141,546 | $498,682,069 | -$2,941,499 | $14.19 | 98 |
| 2021 Q4 | 35,317,227 | $746,760,550 | +$3,654,957 | $21.15 | 96 |
| 2021 Q3 | 27,981,387 | $625,678,377 | +$7,096,019 | $22.35 | 102 |
| 2021 Q2 | 27,584,397 | $684,200,429 | -$121,336,833 | $24.81 | 94 |
| 2021 Q1 | 31,507,544 | $913,643,371 | +$20,106,775 | $29.01 | 109 |
| 2020 Q4 | 30,844,129 | $813,955,792 | +$45,233,337 | $25.80 | 94 |
| 2020 Q3 | 28,988,756 | $892,491,434 | +$220,301,852 | $30.79 | 103 |
| 2020 Q2 | 21,827,155 | $543,916,299 | -$2,246,835 | $24.92 | 75 |
| 2020 Q1 | 22,025,386 | $466,923,796 | +$63,234,074 | $21.20 | 66 |
| 2019 Q4 | 19,000,379 | $421,605,474 | +$18,157,481 | $22.19 | 57 |
| 2019 Q3 | 12,742,598 | $288,264,741 | +$54,821,814 | $22.75 | 54 |
| 2019 Q2 | 10,674,595 | $204,526,000 | +$204,526,000 | $19.15 | 48 |