| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 12% | 25,383,077 | 0 | 25,383,077 | Kristin Mariani | Head of North America Compliance, CCO | |
| Janus Henderson Biotech Innovation Master Fund Ltd | 10% | 21,576,145 | 0 | 21,576,145 | Kristin Mariani | Head of North America Compliance, CCO |