Security Snapshot

Definium Therapeutics, Inc. - Common Shares, no par value per share (DFTX) Institutional Ownership

CUSIP: 24477V105

13F Institutional Holders and Ownership History from Q4 2025 to Q2 2026

Latest Period

Q2 2026

Institutions Reporting

356

Shares (Excl. Options)

112,873,991

Price

$47.04

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Latest holder snapshot 5 signals
Portfolio coverage rank
0.01%
Share change
+32,800,078
Value change
+$1,632,500,660
Number of holders
356
Issuer context Names, identifiers, and filing context for this profile. 2 identity fields
Shares outstanding
133,888,889
SEC-reported price per share
$42.16
13F Shares, Excluding Options vs Price
13F Value, Excluding Options
Total Investors

Key facts

  • DFTX - Definium Therapeutics, Inc. - Common Shares, no par value per share is tracked under CUSIP 24477V105.
  • 356 institutions reported positions in Q2 2026.
  • 4 significant owners is listed from Schedule 13D/13G reporting.

Change

  • Holder count moved from 244 to 356 between Q1 2026 and Q2 2026.
  • SEC-reported value moved from $1,474,447,042 to $5,309,052,281.

Research use

  • You can quickly see who holds this security, then open quarter and manager detail pages for full evidence.
  • 13F and Schedule 13D/13G sections are kept together so you can cross-check institutional and beneficial ownership context.

Evidence

Source: SEC Form 13F

Latest holder context comes from 356 institutions filings for Q2 2026.

Open SEC evidence

Security key

24477V105

Latest holder period

Q2 2026

13F holders

356

13D/G owners

4

CIK / CUSIP context first

13D/G owners

Significant owners

Large-stake holder rows connected to Schedule 13D/G evidence.

Rows
4
Security
DFTX
Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
DRIEHAUS CAPITAL MANAGEMENT LLC 5.4% -18% $298,796,297 +$13,447,430 6,845,276 +4.7% DRIEHAUS CAPITAL MANAGEMENT LLC 30 Jun 2026
Avoro Capital Advisors LLC 5.1% 5,000,000 Avoro Capital Advisors LLC 31 Dec 2025
Deep Track Capital, LP 3% -42% $66,750,000 -$59,553,015 3,000,000 -47% Deep Track Capital, LP 31 Mar 2026
Commodore Capital LP 1.8% -77% $105,196,500 -$219,069,529 2,410,000 -68% Commodore Capital LP 30 Jun 2026

As of 30 Jun 2026, 356 institutional investors reported holding 112,873,991 shares of Definium Therapeutics, Inc. - Common Shares, no par value per share (DFTX). This represents 84% of the company’s total 133,888,889 outstanding shares.

13F concentration

Top 25 institutional shareholders

Largest 13F positions for this security by reported shares and value.

Top holder share
61%
Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
BlackRock, Inc. 8.4% 11,232,834 +32% 0.01% $528,392,511
Avoro Capital Advisors LLC 5.4% 7,188,888 +44% 3% $338,165,292
Driehaus Capital Management LLC 5.1% 6,845,276 +16% 1.9% $322,001,783
Jupiter Topco LLC 4.2% 5,615,645 0% 0.11% $264,002,611
Capital World Investors 4% 5,367,723 0.03% $252,497,690
FMR LLC 3.5% 4,752,921 +163% 0.01% $223,577,402
PRICE T ROWE ASSOCIATES INC /MD/ 3.5% 4,652,032 +6546% 0.02% $218,833,000
GEODE CAPITAL MANAGEMENT, LLC 2.7% 3,644,813 +46% 0.01% $171,482,802
STATE STREET CORP 2.3% 3,065,390 +24% 0% $144,195,946
Capital International Investors 2.2% 2,963,410 0.03% $139,398,806
Octagon Capital Advisors LP 2.2% 2,950,000 +21% 13% $138,768,000
WELLINGTON MANAGEMENT GROUP LLP 2.2% 2,949,734 +126% 0.02% $138,755,487
Deep Track Capital, LP 2.1% 2,750,000 -8.3% 1.9% $129,360,000
Commodore Capital LP 1.5% 2,000,000 0% 5.6% $94,080,000
GOLDMAN SACHS GROUP INC 1.3% 1,800,852 +7.5% 0.01% $84,712,079
CITADEL ADVISORS LLC 1.3% 1,688,587 +27% 0.05% $79,431,133
VANGUARD PORTFOLIO MANAGEMENT LLC 1.2% 1,648,426 +89% 0% $77,541,959
RA CAPITAL MANAGEMENT, L.P. 1.1% 1,500,000 0.61% $70,560,000
VANGUARD CAPITAL MANAGEMENT LLC 1.1% 1,486,454 +36% 0% $69,922,796
Siren, L.L.C. 1.1% 1,419,493 +54% 1.4% $66,772,951
MARSHALL WACE, LLP 0.97% 1,298,946 +8.2% 0.05% $61,102,420
NORTHERN TRUST CORP 0.87% 1,169,238 +46% 0.01% $55,000,956
AMERIPRISE FINANCIAL INC 0.86% 1,148,363 +19% 0.01% $54,018,997
Nuveen, LLC 0.83% 1,105,314 +58% 0.01% $51,993,971
CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.81% 1,083,576 +34% 0.01% $50,971,415

Quarter history

Institutional holders across reporting periods

Holder count, reported shares/value, and median price by quarter.

Periods
3
Latest
Q2 2026
Rows shown
1-3 of 3
Period 13F Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2026 Q2 112,873,991 $5,309,052,281 +$1,632,500,660 $47.04 356
2026 Q1 78,036,684 $1,474,447,042 +$1,211,067,091 $18.90 244
2025 Q4 11,252,538 $150,679,840 +$150,673,017 $13.39 8
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