Significant Ownership of PERCEPTIVE ADVISORS LLC

Signature - Title
/s/ Joseph Edelman - Joseph Edelman, Managing Member
Location
New York, NY
Summary
This page shows a list of all the recent SCHEDULE 13D/G filings made by PERCEPTIVE ADVISORS LLC.

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Significant Ownership of PERCEPTIVE ADVISORS LLC

Sym Company Class Ownership Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
ADGM Adagio Medical Holdings, Inc. Common Stock, par value $0.0001 per share 58% $14,555,572 15,321,655 0% Perceptive Advisors LLC 31 Dec 2025
ATHA LeonaBio, Inc. Common Stock, $0.0001 par value 20% $13,052,440 -$68,291 1,859,322 -0.52% Perceptive Advisors LLC 16 Jan 2026
LYRA Lyra Therapeutics, Inc. Common Stock, $0.001 par value 16% $22,174 255,750 Perceptive Advisors LLC 12 Aug 2025
MGTX MeiraGTx Holdings plc Ordinary Shares, nominal value $0.00003881 per share 13% $85,934,055 10,441,562 Perceptive Advisors LLC 31 Dec 2025
SLDB Solid Biosciences Inc. Common Stock, $0.001 par value per share 13% $82,945,717 +$238,392 11,969,079 +0.29% Perceptive Advisors LLC 09 Mar 2026
NAUT Nautilus Biotechnology, Inc. Common Stock, $0.0001 par value per share 10% $11,149,148 +$192,185 12,815,113 +1.8% Perceptive Advisors LLC 20 Jun 2025
ANRO Alto Neuroscience, Inc. Common Stock, $0.0001 par value per share 10% $53,623,911 +$20,798,926 3,249,934 +63% Perceptive Advisors LLC 31 Dec 2025
ENGN enGene Holdings Inc. Common Shares 10% $47,123,411 6,770,605 Perceptive Advisors LLC 11 Nov 2025
PALI PALISADE BIO, INC. Common Stock, $0.01 par value 10% $29,184,225 +$5,677,630 15,200,117 +24% Perceptive Advisors LLC 31 Dec 2025
IKT INHIBIKASE THERAPEUTICS, INC. Common Stock, $0.001 par value 10% $25,633,286 12,816,643 Perceptive Advisors LLC 31 Dec 2025
IRD Opus Genetics, Inc. Common Stock, $0.0001 par value per share 10% $14,420,050 +$5,353,943 7,174,154 +59% Perceptive Advisors LLC 31 Dec 2025
OBIO Orchestra BioMed Holdings, Inc. Common Stock, par value $0.0001 per share 10% $14,085,110 5,679,480 Perceptive Advisors LLC 30 Sep 2025
TRAW Traws Pharma, Inc. Common Stock, par value $0.01 per share 10% $1,641,628 +$632,468 886,887 +63% Perceptive Advisors LLC 30 Sep 2025
NVNO enVVeno Medical Corporation Common Stock, $0.00001 par value 10% $737,465 2,048,515 Perceptive Advisors LLC 31 Dec 2025
TRIB Trinity Biotech plc Class A Ordinary Shares, $0.0001 par value per share 9.9% $1,158,595,827 -$28,350,022 1,463,058,248 -2.4% Perceptive Advisors LLC 22 Jan 2026
OM Outset Medical, Inc. Common Stock, $0.001 par value per share 9.5% $32,688,000 5,625,000 Perceptive Advisors LLC 08 Jan 2025
TENX Tenax Therapeutics, Inc. Common Stock, $0.0001 par value per share 9.1% $8,568,085 +$1,958,998 569,308 +30% Perceptive Advisors LLC 31 Dec 2025
AMLX Amylyx Pharmaceuticals, Inc. Common Stock, $0.0001 par value per share 8.2% $121,662,640 +$14,650,251 8,952,365 +14% Perceptive Advisors LLC 30 Sep 2025
IVVD INVIVYD, INC. Common Stock, $0.0001 par value per share 7.9% $40,738,260 21,785,166 Perceptive Advisors LLC 18 Nov 2025
XFOR X4 PHARMACEUTICALS, INC. Common Stock, par value $0.001 per share 7.6% $20,980,760 6,064,680 Perceptive Advisors LLC 27 Oct 2025
SABS SAB BIOTHERAPEUTICS, INC. Common Stock, $0.0001 par value per share 7.3% $13,088,916 3,471,861 Perceptive Advisors LLC 14 Jan 2026
PRAX Praxis Precision Medicines, Inc. Common Stock, par value $0.0001 per share 7.2% $575,742,162 +$182,728,171 1,995,986 +46% Perceptive Advisors LLC 31 Dec 2025
ALDX Aldeyra Therapeutics, Inc. Common Stock, par value $0.001 per share 7% $17,286,660 -$4,281,484 4,185,632 -20% Perceptive Advisors LLC 31 Dec 2025
CELC Celcuity Inc. Common Stock, $0.001 par value per share 6.8% $329,324,442 +$51,021,529 3,160,200 +18% Perceptive Advisors LLC 31 Dec 2025
RYTM Rhythm Pharmaceuticals, Inc. Common Stock, $0.001 par value per share 6.8% $284,913,835 4,423,441 Perceptive Advisors LLC 31 Mar 2025
OM Outset Medical, Inc. Common Stock, $0.001 par value per share 6.7% $14,028,758 1,208,334 Perceptive Advisors LLC 31 Mar 2025
EDSA EDESA BIOTECH, INC. Common Shares, without par value 6.7% $551,974 563,239 Perceptive Advisors LLC 09 Mar 2026
CTMX CytomX Therapeutics, Inc. Common Stock, $0.00001 par value per share 5.9% $22,458,029 9,680,185 Perceptive Advisors LLC 14 Aug 2025
RLAY RELAY THERAPEUTICS, INC. Common Stock, par value $0.001 per share 5.3% $81,821,108 9,404,725 Perceptive Advisors LLC 12 Mar 2026
BDSX Biodesix, Inc. Common Stock, par value $0.001 per share 5.1% $4,374,112 +$570,000 7,673,880 +15% Perceptive Advisors LLC 12 May 2025
IVA Inventiva S.A. Ordinary shares, nominal value euro 0.01 per share 5% $42,246,764 +$10,098,434 7,300,666 +31% Perceptive Advisors LLC 30 Sep 2025
TVTX TRAVERE THERAPEUTICS, INC. Common Stock, par value $0.0001 per share 4.8% $124,537,820 -$17,973,533 4,278,180 -13% Perceptive Advisors LLC 31 Dec 2025
AVR Anteris Technologies Global Corp. Common Stock, par value $0.0001 per share 4.7% $5,933,852 -$2,557,348 1,705,130 -30% Perceptive Advisors LLC 30 Jun 2025
DRUG Bright Minds Biosciences Inc. Common Shares, without par value 4.6% $40,171,019 +$414,952 449,290 +1% Perceptive Advisors LLC 31 Dec 2025
ACLX Arcellx, Inc. Common Stock, par value $0.001 per share 4.5% $162,432,900 -$29,397,733 2,478,000 -15% Perceptive Advisors LLC 30 Jun 2025
RAPT RAPT Therapeutics, Inc. Common Stock, $0.0001 par value per share 4.5% $5,115,600 5,880,000 Perceptive Advisors LLC 31 Dec 2024
EWTX Edgewise Therapeutics, Inc. Common Stock, par value $0.0001 per share 4.4% $60,458,535 -$22,875,429 4,639,949 -27% Perceptive Advisors LLC 30 Jun 2025
SYRE Spyre Therapeutics, Inc. Common Stock, $0.0001 par value per share 4.4% $38,672,339 -$185,961,697 2,574,723 -80% Perceptive Advisors LLC 31 Dec 2024
AORT ARTIVION, INC. Common Stock, $0.01 par value 4.3% $85,526,800 2,020,000 Perceptive Advisors LLC 30 Sep 2025
IOVA Iovance Biotherapeutics, Inc. Common Stock, par value $0.000041666 per share 3.8% $45,599,285 -$33,120,382 12,808,788 -42% Perceptive Advisors LLC 31 Mar 2025
EOLS Evolus, Inc. Common Stock, $0.00001 par value per share 3.8% $23,461,512 -$15,682,755 2,474,843 -40% Perceptive Advisors LLC 30 Jun 2025
ENSC Ensysce Biosciences, Inc. Common Stock, par value $0.0001 per share 3.7% $264,331 86,666 0% Perceptive Advisors LLC 31 Mar 2025
BBNX Beta Bionics, Inc. Common Stock, $0.0001 par value per share 3.7% $21,609,324 1,593,608 Perceptive Advisors LLC 31 Mar 2025
CTNM Contineum Therapeutics, Inc. Class A Common Stock, par value $0.001 per share 3.2% $2,776,959 -$2,944,799 699,486 -51% Perceptive Advisors LLC 30 Jun 2025
CRGX CARGO Therapeutics, Inc. Common Stock, $0.001 par value per share 2.5% $5,420,850 1,170,810 Perceptive Advisors LLC 23 Apr 2025
FBRX Forte Biosciences, Inc. Common Stock, par value $0.001 per share 2.5% $1,209,840 163,935 Perceptive Advisors LLC 31 Dec 2024
FOLD Amicus Therapeutics, Inc. Common Stock, par value $0.01 per share 2.4% $43,290,927 -$82,061,910 7,412,830 -65% Perceptive Advisors LLC 30 Jun 2025
APLT Applied Therapeutics, Inc. Common Stock, $0.0001 par value per share 2.4% $1,115,400 2,860,000 Perceptive Advisors LLC 31 Dec 2024
SRZN Surrozen, Inc. Common Stock, $0.0001 par value per share 1.9% $1,669,993 166,666 0% Perceptive Advisors LLC 31 Mar 2025
VRCA Verrica Pharmaceuticals, Inc. Common Stock, $0.0001 par value per share 1.6% $725,926 -$1,592,338 1,481,481 -69% Perceptive Advisors LLC 31 Mar 2025
VRNA Verona Pharma plc Ordinary shares, nominal value GBP 0.05 per share 0% $0 -$587,715,036 0 -100% Perceptive Advisors LLC 30 Sep 2025
TIL Instil Bio, Inc. Common Stock, par value $0.000001 per share 0% $0 0 Perceptive Advisors LLC 31 Mar 2025
ATXS Astria Therapeutics, Inc. Common Stock, par value $0.001 per share 0% $0 -$82,494,542 0 -100% Perceptive Advisors LLC 26 Jan 2026
ACRV Acrivon Therapeutics, Inc. Common Stock, par value $0.001 per share 0% $0 -$3,600,801 0 -100% Perceptive Advisors LLC 02 Jun 2025
KALA KALA BIO, Inc. Common Stock, par value $0.001 per share 0% $0 -$831,712 0 -100% Perceptive Advisors LLC 30 Sep 2025
LYRA Lyra Therapeutics, Inc. Common Stock, $0.001 par value 0% $0 -$595,704 0 -100% Perceptive Advisors LLC 21 Nov 2025
OKUR OnKure Therapeutics, Inc. Common Stock, par value $0.0001 per share $0 0 Perceptive Advisors LLC 30 Jun 2025

Schedules 13D/G Reported by PERCEPTIVE ADVISORS LLC:

Sym Target Class Ownership Change Current Shares Change Value Reporting name Form Report Period Filing Date
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

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