PERCEPTIVE ADVISORS LLC

Holdings History for Spyre Therapeutics, Inc. - Common Stock, $0.0001 par value (SYRE)

Symbol: SYRE on Nasdaq
Investment type: Equity / Common Stock, $0.0001 par value
Latest Disclosed Shares Owned: 2,574,723 shares
Security Ownership %: 4.4%

Shares, Excluding Options vs Price

Value, Excluding Options

Perceptive Advisors LLC ownership in Spyre Therapeutics, Inc. Common Stock, $0.0001 par value (SYRE)

14 Feb 2025 - Perceptive Advisors LLC has filed an SCHEDULE 13G/A form with the Securities and Exchange Commission (SEC) disclosing ownership of 2,574,723 shares of Spyre Therapeutics, Inc. Common Stock, $0.0001 par value (SYRE). This represents 4.4% ownership of the company. This is the first filing by PERCEPTIVE ADVISORS LLC disclosing ownership of Spyre Therapeutics, Inc. Common Stock, $0.0001 par value (SYRE).

Reporting Name	Ownership %	Change	Value $	Shares owned	Change	Activity %	Price	Form	Report date	Filing time
Perceptive Advisors LLC	4.4%	-56%	$38,672,339	2,574,723	-10,019,488	-80%	$15.02	13G/A	31 Dec 2024	14 Feb 2025, 16:15

Holdings date	Weight	Change	Value $	Shares	Change	Activity %	Price	All Holders
30 Sep 2025	0.6%	-0.15%	$20,605,498	1,229,445	-300,000	-20%	$16.76	Q3 2025
30 Jun 2025	0.86%	-0.44%	$22,895,792	1,529,445	-783,827	-34%	$14.97	Q2 2025
31 Mar 2025	1.3%	-0.15%	$37,324,644	2,313,272	-261,451	-10%	$16.14	Q1 2025
31 Dec 2024	1.7%	-0.19%	$59,939,551	2,574,723	-297,824	-10%	$23.28	Q4 2024
30 Sep 2024	1.8%	-0.1%	$84,481,607	2,872,547	-158,471	-5.2%	$29.41	Q3 2024
30 Jun 2024	1.7%	+0.2%	$71,259,233	3,031,018	+474,339	+19%	$23.51	Q2 2024
31 Mar 2024	1.7%	-0.04%	$96,974,834	2,556,679	-50,000	-1.9%	$37.93	Q1 2024
31 Dec 2023	1.3%	+1.2%	$56,095,732	2,606,679	+2,525,563	+3114%	$21.52	Q4 2023
30 Sep 2023	0.03%	+0.03%	$993,671	81,116	+81,116	NEW	$12.25	Q3 2023

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.