| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 11.32% | $52,456,043 | 4,857,041 | Eventide Asset Management, LLC | 31 Jan 2025 | |||
| Zone Healthcare Holdings, LLC | 9.9% | +25% | $85,717,590 | +$17,618,729 | 4,313,920 | +25.9% | Dapice Joshua J. | 30 Sep 2025 |
| Farallon Capital Partners, L.P. | 9.7% | $57,005,155 | 4,203,920 | Dapice Joshua J. | 30 Jun 2025 | |||
| Wellington Hadley Harbor Aggregator IV, L.P. | 9% | +31.4% | $42,137,269 | +$10,800,000 | 3,901,599 | +34.5% | Wellington Hadley Harbor Aggregator IV, L.P. | 31 Mar 2025 |
| WELLINGTON MANAGEMENT GROUP LLP | 9% | $42,137,269 | 3,901,599 | Wellington Management Group LLP | 31 Mar 2025 | |||
| Soleus BB SPV, LLC | 8.8% | $40,989,683 | 3,795,341 | Soleus Capital Management, L.P. | 31 Mar 2025 | |||
| MORGAN STANLEY | 8.6% | +25.7% | $74,305,196 | +$16,109,185 | 3,739,567 | +27.7% | Morgan Stanley | 30 Sep 2025 |
| Sands Capital Life Sciences Pulse Fund II, L.P. | 8.2% | +12.9% | $48,410,732 | +$5,636,946 | 3,570,113 | +13.2% | Sands Capital Life Sciences Pulse Fund II. L.P. | 30 Jun 2025 |
| RTW INVESTMENTS, LP | 7.6% | $35,638,585 | 3,299,869 | RTW Investments, LP | 31 Mar 2025 | |||
| BlackRock, Inc. | 6.4% | $55,215,708 | 2,778,764 | BlackRock, Inc. | 30 Sep 2025 | |||
| VANGUARD GROUP INC | 5.09% | $44,035,596 | 2,216,185 | The Vanguard Group | 30 Sep 2025 | |||
| PERCEPTIVE ADVISORS LLC | 3.68% | $21,609,324 | 1,593,608 | Perceptive Advisors LLC | 31 Mar 2025 | |||
| MILLENNIUM MANAGEMENT LLC | 1.8% | -70% | $15,835,993 | -$29,602,207 | 796,964 | -65.1% | Millennium Management LLC | 30 Sep 2025 |