| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 31% | 0% | $420,817,508 | 22,970,388 | 0% | EcoR1 Capital, LLC | 16 Nov 2025 | |
| MORGAN STANLEY | 5.8% | $50,973,512 | 4,055,172 | Morgan Stanley | 31 Mar 2025 | |||
| BIOTECHNOLOGY VALUE FUND L P | 5.2% | $67,271,988 | 3,938,641 | BVF PARTNERS L P/IL | 30 Sep 2025 | |||
| Redmile Group, LLC | 4.9% | -12% | $63,294,210 | -$7,598,499 | 3,705,750 | -11% | Redmile Group, LLC | 30 Sep 2025 |
| BlackRock, Inc. | 4.8% | $44,677,977 | 3,559,828 | BlackRock, Inc. | 30 Jun 2025 |
As of 30 Sep 2025, 181 institutional investors reported holding 73,699,594 shares of Zymeworks Inc. - Common Stock (ZYME). This represents 98% of the company’s total 74,822,111 outstanding shares.
The largest institutional shareholders of Zymeworks Inc. - Common Stock (ZYME) together control 87% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 31% | 22,970,388 | 0% | 19% | $392,334,227 |
| Rubric Capital Management LP | 6.3% | 4,710,551 | 0% | 1.1% | $80,456,211 |
| BlackRock, Inc. | 5.3% | 3,989,533 | +5.1% | 0% | $68,141,224 |
| MORGAN STANLEY | 5.3% | 3,984,585 | -4.6% | 0% | $68,056,714 |
| BVF INC/IL | 5.3% | 3,938,641 | -8.6% | 2.7% | $67,271,988 |
| Redmile Group, LLC | 5% | 3,705,750 | -11% | 6.2% | $63,294,210 |
| VANGUARD GROUP INC | 2.9% | 2,154,434 | -13% | 0% | $36,797,732 |
| PERCEPTIVE ADVISORS LLC | 2.8% | 2,090,663 | +64% | 1% | $35,708,524 |
| Vestal Point Capital, LP | 2.4% | 1,765,000 | +53% | 1.4% | $30,146,200 |
| UBS AM, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS LLC | 2.3% | 1,710,463 | -30% | 0.01% | $29,214,708 |
| Blackstone Inc. | 2.2% | 1,616,290 | -2.4% | 0.12% | $27,606,233 |
| DEUTSCHE BANK AG\ | 2.1% | 1,544,898 | +0.01% | 0.01% | $26,386,859 |
| Assenagon Asset Management S.A. | 1.8% | 1,326,774 | +169% | 0.03% | $22,661,300 |
| DIMENSIONAL FUND ADVISORS LP | 1.6% | 1,190,838 | -0.13% | 0% | $20,340,605 |
| Nextech Invest, Ltd. | 1.5% | 1,113,946 | 0% | 2.9% | $19,026,198 |
| MILLENNIUM MANAGEMENT LLC | 1.5% | 1,104,813 | +852% | 0.01% | $18,870,206 |
| TANG CAPITAL MANAGEMENT LLC | 1.5% | 1,100,000 | 0% | 0.72% | $18,788,000 |
| STATE STREET CORP | 1.4% | 1,081,189 | -0.67% | 0% | $18,466,708 |
| Prosight Management, LP | 1% | 749,611 | -43% | 3.1% | $12,803,356 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.91% | 678,636 | -3.8% | 0% | $11,590,695 |
| Nuveen, LLC | 0.76% | 565,385 | -14% | 0% | $9,656,776 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0.75% | 564,000 | +18% | 0.02% | $9,633,120 |
| GOLDMAN SACHS GROUP INC | 0.59% | 443,525 | +3.4% | 0% | $7,575,407 |
| RENAISSANCE TECHNOLOGIES LLC | 0.58% | 431,700 | -19% | 0.01% | $7,373,436 |
| JUPITER ASSET MANAGEMENT LTD | 0.47% | 350,660 | -5.1% | 0.05% | $5,989,273 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 665,992 | $17,535,294 | -$17,780,369 | $26.33 | 5 |
| 2025 Q3 | 73,699,594 | $1,258,820,490 | -$22,883,397 | $17.08 | 181 |
| 2025 Q2 | 75,621,323 | $949,023,010 | +$68,009,464 | $12.55 | 179 |
| 2025 Q1 | 70,389,436 | $838,494,320 | +$42,500,933 | $11.91 | 182 |
| 2024 Q4 | 66,481,090 | $973,230,925 | -$246,877 | $14.64 | 171 |
| 2024 Q3 | 66,502,275 | $834,701,900 | -$15,271,356 | $12.55 | 161 |
| 2024 Q2 | 68,183,439 | $580,274,097 | +$16,468,836 | $8.51 | 160 |
| 2024 Q1 | 67,744,225 | $712,627,244 | +$31,495,473 | $10.52 | 167 |
| 2023 Q4 | 64,825,365 | $673,552,112 | +$31,038,276 | $10.39 | 153 |
| 2023 Q3 | 62,318,186 | $395,187,634 | -$7,310,307 | $6.34 | 136 |
| 2023 Q2 | 63,418,288 | $547,948,381 | +$55,194,956 | $8.64 | 135 |
| 2023 Q1 | 56,707,830 | $512,639,046 | +$19,986,782 | $9.04 | 113 |
| 2022 Q4 | 55,146,033 | $433,446,373 | +$429,612,295 | $7.86 | 89 |
| 2022 Q3 | 78,394 | $482,000 | +$482,000 | $6.15 | 1 |