Security Snapshot

Zymeworks Inc. - Common Stock, $0.00001 par value per share (ZYME) Institutional Ownership

CUSIP: 98985Y108

13F Institutional Holders and Ownership History from Q3 2022 to Q1 2026

Latest Period

Q4 2025

Institutions Reporting

205

Shares (Excl. Options)

71,441,303

Price

$26.33

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Type / Class
Equity / Common Stock, $0.00001 par value per share
Symbol
ZYME on Nasdaq
Shares outstanding
73,603,315
Price per share
$25.04
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
71,441,303
Total reported value
$1,881,059,421
% of total 13F portfolios
0%
Share change
-2,172,328
Value change
-$32,229,794
Number of holders
205
Price from insider filings
$25.04
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

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Quick Takeaways

  • ZYME - Zymeworks Inc. - Common Stock, $0.00001 par value per share is tracked under CUSIP 98985Y108.
  • 205 institutions reported positions in Q4 2025.
  • 7 significant owners is listed from Schedule 13D/13G reporting.

What Changed

  • Holder count moved from 205 to 12 between Q4 2025 and Q1 2026.
  • Reported value moved from $1,881,059,421 to $3,489,826.

Why This Matters

  • You can quickly see who holds this security, then open quarter and manager detail pages for full evidence.
  • 13F and Schedule 13D/13G sections are kept together so you can cross-check institutional and beneficial ownership context.

Source Evidence

Source: SEC Form 13F

Latest holder context comes from 205 institutions filings for Q4 2025.

Open SEC Evidence

Investment Quick Answers

What is CUSIP 98985Y108?
CUSIP 98985Y108 identifies ZYME - Zymeworks Inc. - Common Stock, $0.00001 par value per share in SEC 13F datasets.

Where can I see the latest institutional holders?
Review the Q4 2025 holders report and the ownership history table below.

Significant Owners of Zymeworks Inc. - Common Stock, $0.00001 par value per share (ZYME) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
EcoR1 Capital, LLC 31% 0% $420,817,508 22,970,388 0% EcoR1 Capital, LLC 16 Nov 2025
Rubric Capital Management LP 7.7% $153,065,000 5,750,000 Rubric Capital Management LP 31 Dec 2025
PERCEPTIVE ADVISORS LLC 5.4% $99,527,035 3,974,579 Perceptive Advisors LLC 08 Apr 2026
BIOTECHNOLOGY VALUE FUND L P 5.2% $67,271,988 3,938,641 BVF PARTNERS L P/IL 30 Sep 2025
Redmile Group, LLC 4.9% -12% $63,294,210 -$7,598,499 3,705,750 -11% Redmile Group, LLC 30 Sep 2025
BlackRock, Inc. 4.8% $44,677,977 3,559,828 BlackRock, Inc. 30 Jun 2025
MORGAN STANLEY 3.4% -40% $67,062,249 -$40,886,430 2,519,243 -38% Morgan Stanley 31 Dec 2025

As of 31 Dec 2025, 205 institutional investors reported holding 71,441,303 shares of Zymeworks Inc. - Common Stock, $0.00001 par value per share (ZYME). This represents 97% of the company’s total 73,603,315 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of Zymeworks Inc. - Common Stock, $0.00001 par value per share (ZYME) together control 84% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
EcoR1 Capital, LLC 31% 22,970,388 0% 28% $604,810,316
Rubric Capital Management LP 7.8% 5,750,000 +22% 1.8% $151,397,500
BlackRock, Inc. 6.2% 4,595,548 +15% 0% $121,000,779
BVF INC/IL 5.4% 3,938,641 0% 3.5% $103,704,418
PERCEPTIVE ADVISORS LLC 4.4% 3,261,850 +56% 1.6% $85,884,511
MORGAN STANLEY 3.5% 2,593,080 -35% 0% $68,275,801
VANGUARD GROUP INC 3.2% 2,328,727 +8.1% 0% $61,315,382
BNP PARIBAS ASSET MANAGEMENT Holding S.A. 2.5% 1,822,048 0.06% $47,975,000
Siren, L.L.C. 2.3% 1,680,121 1.3% $44,237,586
DEUTSCHE BANK AG\ 2.2% 1,595,833 +3.3% 0.01% $42,018,282
DIMENSIONAL FUND ADVISORS LP 1.6% 1,159,215 -2.7% 0.01% $30,523,404
Nextech Invest, Ltd. 1.5% 1,113,946 0% 2.8% $29,330,198
STATE STREET CORP 1.4% 1,037,642 -4% 0% $27,321,114
Capricorn Fund Managers Ltd 1.4% 1,022,840 6.5% $26,931,377
Vestal Point Capital, LP 1.2% 865,000 -51% 0.84% $22,775,450
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.95% 700,002 +123% 0.01% $18,431,053
ADAGE CAPITAL PARTNERS GP, L.L.C. 0.9% 663,546 +18% 0.03% $17,471,166
Nuveen, LLC 0.88% 648,326 +15% 0% $17,070,424
GEODE CAPITAL MANAGEMENT, LLC 0.88% 647,970 -4.5% 0% $17,060,446
Assenagon Asset Management S.A. 0.88% 647,374 -51% 0.03% $17,045,357
FMR LLC 0.76% 560,086 +15839% 0% $14,747,059
Prosight Management, LP 0.72% 530,393 -29% 2.9% $13,965,248
Redmile Group, LLC 0.67% 491,654 -87% 0.95% $12,945,250
Qube Research & Technologies Ltd 0.64% 474,290 +86% 0.02% $12,488,056
ALGERT GLOBAL LLC 0.58% 423,646 +104% 0.17% $11,155,000

Institutional Holders of Zymeworks Inc. - Common Stock, $0.00001 par value per share (ZYME) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2026 Q1 139,368 $3,489,826 +$754,267 $25.04 12
2025 Q4 71,441,303 $1,881,059,421 -$32,229,794 $26.33 205
2025 Q3 73,689,534 $1,258,648,393 -$22,925,180 $17.08 181
2025 Q2 75,621,323 $949,023,010 +$68,009,464 $12.55 179
2025 Q1 70,389,436 $838,494,320 +$42,500,933 $11.91 182
2024 Q4 66,481,090 $973,230,925 -$246,877 $14.64 171
2024 Q3 66,502,275 $834,701,900 -$15,271,356 $12.55 161
2024 Q2 68,183,439 $580,274,097 +$16,468,836 $8.51 160
2024 Q1 67,744,225 $712,627,244 +$31,495,473 $10.52 167
2023 Q4 64,825,365 $673,552,112 +$31,038,276 $10.39 153
2023 Q3 62,318,186 $395,187,634 -$7,310,307 $6.34 136
2023 Q2 63,418,288 $547,948,381 +$55,194,956 $8.64 135
2023 Q1 56,707,830 $512,639,046 +$19,986,782 $9.04 113
2022 Q4 55,146,033 $433,446,373 +$429,612,295 $7.86 89
2022 Q3 78,394 $482,000 +$482,000 $6.15 1

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