Security Snapshot

Zymeworks Inc. - Common Stock, $0.00001 par value per share (ZYME) Institutional Ownership

CUSIP: 98985Y108

13F Institutional Holders and Ownership History from Q3 2022 to Q2 2026

Latest Period

Q2 2026

Institutions Reporting

202

Shares (Excl. Options)

68,308,834

Price

$26.14

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Latest holder snapshot 5 signals
Portfolio coverage rank
0%
Share change
-1,886,961
Value change
-$48,373,475
Number of holders
202
Issuer context Names, identifiers, and filing context for this profile. 3 identity fields
Shares outstanding
73,761,855
SEC-reported price per share
$23.36
Insider filing price
$23.36
13F Shares, Excluding Options vs Price
13F Value, Excluding Options
Total Investors

Key facts

  • ZYME - Zymeworks Inc. - Common Stock, $0.00001 par value per share is tracked under CUSIP 98985Y108.
  • 202 institutions reported positions in Q2 2026.
  • 7 significant owners is listed from Schedule 13D/13G reporting.

Change

  • Holder count moved from 210 to 202 between Q1 2026 and Q2 2026.
  • SEC-reported value moved from $1,760,015,725 to $1,784,641,822.

Research use

  • You can quickly see who holds this security, then open quarter and manager detail pages for full evidence.
  • 13F and Schedule 13D/13G sections are kept together so you can cross-check institutional and beneficial ownership context.

Evidence

Source: SEC Form 13F

Latest holder context comes from 202 institutions filings for Q2 2026.

Open SEC evidence

Security key

98985Y108

Latest holder period

Q2 2026

13F holders

202

13D/G owners

7

CIK / CUSIP context first

13D/G owners

Significant owners

Large-stake holder rows connected to Schedule 13D/G evidence.

Rows
7
Security
ZYME
Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
EcoR1 Capital, LLC 31% 0% $420,817,508 22,970,388 0% EcoR1 Capital, LLC 16 Nov 2025
Rubric Capital Management LP 9.5% +23% $175,280,000 +$31,300,000 7,000,000 +22% Rubric Capital Management LP 31 Mar 2026
PERCEPTIVE ADVISORS LLC 5.4% $99,527,035 3,974,579 Perceptive Advisors LLC 08 Apr 2026
BIOTECHNOLOGY VALUE FUND L P 5.2% $67,271,988 3,938,641 BVF PARTNERS L P/IL 30 Sep 2025
Redmile Group, LLC 4.9% -12% $63,294,210 -$7,598,499 3,705,750 -11% Redmile Group, LLC 30 Sep 2025
BlackRock, Inc. 4.8% $44,677,977 3,559,828 BlackRock, Inc. 30 Jun 2025
MORGAN STANLEY 3.4% -40% $67,062,249 -$40,886,430 2,519,243 -38% Morgan Stanley 31 Dec 2025

As of 30 Jun 2026, 202 institutional investors reported holding 68,308,834 shares of Zymeworks Inc. - Common Stock, $0.00001 par value per share (ZYME). This represents 93% of the company’s total 73,761,855 outstanding shares.

13F concentration

Top 25 institutional shareholders

Largest 13F positions for this security by reported shares and value.

Top holder share
81%
Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
EcoR1 Capital, LLC 31% 22,970,388 0% 30% $600,445,942
Rubric Capital Management LP 9.5% 7,000,000 0% 1.7% $182,980,000
BlackRock, Inc. 5.8% 4,251,030 -6.7% 0% $111,121,925
PERCEPTIVE ADVISORS LLC 5.7% 4,182,953 +19% 1.7% $109,342,391
BVF INC/IL 4.9% 3,649,142 -2.3% 2.4% $95,388,572
MORGAN STANLEY 3% 2,231,260 -10% 0% $58,325,141
BNP PARIBAS ASSET MANAGEMENT Holding S.A. 2.4% 1,781,116 -6.7% 0.05% $46,558,373
VANGUARD CAPITAL MANAGEMENT LLC 2.1% 1,558,998 -8.6% 0% $40,752,208
Assenagon Asset Management S.A. 1.7% 1,252,027 +72% 0.04% $32,727,986
Nextech Invest Ltd. 1.5% 1,113,946 0% 1.4% $29,118,548
STATE STREET CORP 1.5% 1,088,216 +7.6% 0% $28,445,966
DIMENSIONAL FUND ADVISORS LP 1.3% 994,955 -13% 0% $25,995,770
CITADEL ADVISORS LLC 1.2% 914,136 -21% 0.01% $23,895,516
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 1.2% 889,802 0.03% $23,259,000
FMR LLC 0.95% 702,568 +5.3% 0% $18,365,133
GEODE CAPITAL MANAGEMENT, LLC 0.94% 692,410 +4.9% 0% $18,099,012
Prosight Management, LP 0.91% 674,434 +25% 3% $17,629,705
Qube Research & Technologies Ltd 0.8% 593,590 +16% 0.02% $15,516,443
VANGUARD PORTFOLIO MANAGEMENT LLC 0.69% 510,032 +2% 0% $13,332,236
Redmile Group, LLC 0.67% 491,654 0% 0.86% $12,851,836
Capricorn Fund Managers Ltd 0.66% 486,529 -52% 1% $12,717,868
GOLDMAN SACHS GROUP INC 0.64% 470,822 -21% 0% $12,307,288
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.57% 418,497 -44% 0% $10,939,512
DEUTSCHE BANK AG\ 0.54% 397,190 -57% 0% $10,382,547
Hillsdale Investment Management Inc. 0.52% 382,922 +11% 0.23% $10,009,581

Quarter history

Institutional holders across reporting periods

Holder count, reported shares/value, and median price by quarter.

Periods
16
Latest
Q2 2026
Rows shown
1-16 of 16
Period 13F Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2026 Q2 68,308,834 $1,784,641,822 -$48,373,475 $26.14 202
2026 Q1 70,281,337 $1,760,015,725 -$36,278,385 $25.04 210
2025 Q4 71,450,392 $1,881,298,833 -$32,229,794 $26.33 208
2025 Q3 73,689,534 $1,258,648,393 -$22,925,180 $17.08 181
2025 Q2 75,621,323 $949,023,010 +$68,009,464 $12.55 179
2025 Q1 70,389,436 $838,494,320 +$42,500,933 $11.91 182
2024 Q4 66,481,090 $973,230,925 -$246,877 $14.64 171
2024 Q3 66,502,275 $834,701,900 -$15,271,356 $12.55 161
2024 Q2 68,183,439 $580,274,097 +$16,468,836 $8.51 160
2024 Q1 67,744,225 $712,627,244 +$31,495,473 $10.52 167
2023 Q4 64,825,365 $673,552,112 +$31,038,276 $10.39 153
2023 Q3 62,318,186 $395,187,634 -$7,310,307 $6.34 136
2023 Q2 63,418,288 $547,948,381 +$55,194,956 $8.64 135
2023 Q1 56,707,830 $512,639,046 +$19,986,782 $9.04 113
2022 Q4 55,146,033 $433,446,373 +$429,612,295 $7.86 89
2022 Q3 78,394 $482,000 +$482,000 $6.15 1
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