| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 31% | 0% | $420,817,508 | 22,970,388 | 0% | EcoR1 Capital, LLC | 16 Nov 2025 | |
| Rubric Capital Management LP | 7.7% | $153,065,000 | 5,750,000 | Rubric Capital Management LP | 31 Dec 2025 | |||
| BIOTECHNOLOGY VALUE FUND L P | 5.2% | $67,271,988 | 3,938,641 | BVF PARTNERS L P/IL | 30 Sep 2025 | |||
| Redmile Group, LLC | 4.9% | -12% | $63,294,210 | -$7,598,499 | 3,705,750 | -11% | Redmile Group, LLC | 30 Sep 2025 |
| BlackRock, Inc. | 4.8% | $44,677,977 | 3,559,828 | BlackRock, Inc. | 30 Jun 2025 | |||
| MORGAN STANLEY | 3.4% | -40% | $67,062,249 | -$40,886,430 | 2,519,243 | -38% | Morgan Stanley | 31 Dec 2025 |
As of 31 Dec 2025, 202 institutional investors reported holding 71,402,110 shares of Zymeworks Inc. - Common Stock, $0.00001 par value per share (ZYME). This represents 95% of the company’s total 74,869,792 outstanding shares.
The largest institutional shareholders of Zymeworks Inc. - Common Stock, $0.00001 par value per share (ZYME) together control 82% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 31% | 22,970,388 | 0% | 28% | $604,810,316 |
| Rubric Capital Management LP | 7.7% | 5,750,000 | +22% | 1.8% | $151,397,500 |
| BlackRock, Inc. | 6.1% | 4,595,548 | +15% | 0% | $121,000,779 |
| BVF INC/IL | 5.3% | 3,938,641 | 0% | 3.5% | $103,704,418 |
| PERCEPTIVE ADVISORS LLC | 4.4% | 3,261,850 | +56% | 1.6% | $85,884,511 |
| MORGAN STANLEY | 3.5% | 2,593,080 | -35% | 0% | $68,275,801 |
| VANGUARD GROUP INC | 3.1% | 2,328,727 | +8.1% | 0% | $61,315,382 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 2.4% | 1,822,048 | 0.06% | $47,975,000 | |
| Siren, L.L.C. | 2.2% | 1,680,121 | 1.3% | $44,237,586 | |
| DEUTSCHE BANK AG\ | 2.1% | 1,595,833 | +3.3% | 0.01% | $42,018,282 |
| DIMENSIONAL FUND ADVISORS LP | 1.5% | 1,159,215 | -2.7% | 0.01% | $30,523,404 |
| Nextech Invest, Ltd. | 1.5% | 1,113,946 | 0% | 2.8% | $29,330,198 |
| STATE STREET CORP | 1.4% | 1,037,642 | -4% | 0% | $27,321,114 |
| Capricorn Fund Managers Ltd | 1.4% | 1,022,840 | 6.5% | $26,931,377 | |
| Vestal Point Capital, LP | 1.2% | 865,000 | -51% | 0.84% | $22,775,450 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0.93% | 700,002 | +123% | 0.01% | $18,431,053 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0.89% | 663,546 | +18% | 0.03% | $17,471,166 |
| Nuveen, LLC | 0.87% | 648,326 | +15% | 0% | $17,070,424 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.87% | 647,970 | -4.5% | 0% | $17,060,446 |
| Assenagon Asset Management S.A. | 0.86% | 647,374 | -51% | 0.03% | $17,045,357 |
| FMR LLC | 0.75% | 560,086 | +15839% | 0% | $14,747,059 |
| Prosight Management, LP | 0.71% | 530,393 | -29% | 2.9% | $13,965,248 |
| Redmile Group, LLC | 0.66% | 491,654 | -87% | 0.95% | $12,945,250 |
| Qube Research & Technologies Ltd | 0.63% | 474,290 | +86% | 0.02% | $12,488,056 |
| ALGERT GLOBAL LLC | 0.57% | 423,646 | +104% | 0.17% | $11,155,000 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 71,402,110 | $1,880,021,751 | -$31,723,026 | $26.33 | 202 |
| 2025 Q3 | 73,689,534 | $1,258,648,393 | -$22,924,668 | $17.08 | 181 |
| 2025 Q2 | 75,621,323 | $949,023,010 | +$68,009,464 | $12.55 | 179 |
| 2025 Q1 | 70,389,436 | $838,494,320 | +$42,500,933 | $11.91 | 182 |
| 2024 Q4 | 66,481,090 | $973,230,925 | -$246,877 | $14.64 | 171 |
| 2024 Q3 | 66,502,275 | $834,701,900 | -$15,271,356 | $12.55 | 161 |
| 2024 Q2 | 68,183,439 | $580,274,097 | +$16,468,836 | $8.51 | 160 |
| 2024 Q1 | 67,744,225 | $712,627,244 | +$31,495,473 | $10.52 | 167 |
| 2023 Q4 | 64,825,365 | $673,552,112 | +$31,038,276 | $10.39 | 153 |
| 2023 Q3 | 62,318,186 | $395,187,634 | -$7,310,307 | $6.34 | 136 |
| 2023 Q2 | 63,418,288 | $547,948,381 | +$55,194,956 | $8.64 | 135 |
| 2023 Q1 | 56,707,830 | $512,639,046 | +$19,986,782 | $9.04 | 113 |
| 2022 Q4 | 55,146,033 | $433,446,373 | +$429,612,295 | $7.86 | 89 |
| 2022 Q3 | 78,394 | $482,000 | +$482,000 | $6.15 | 1 |