| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 30.7% | 0% | $420,817,508 | 22,970,388 | 0% | EcoR1 Capital, LLC | 16 Nov 2025 | |
| MORGAN STANLEY | 5.8% | $50,973,512 | 4,055,172 | Morgan Stanley | 31 Mar 2025 | |||
| BIOTECHNOLOGY VALUE FUND L P | 5.2% | $67,271,988 | 3,938,641 | BVF PARTNERS L P/IL | 30 Sep 2025 | |||
| Redmile Group, LLC | 4.9% | -12% | $63,294,210 | -$7,598,499 | 3,705,750 | -11% | Redmile Group, LLC | 30 Sep 2025 |
| BlackRock, Inc. | 4.8% | $44,677,977 | 3,559,828 | BlackRock, Inc. | 30 Jun 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 73,699,594 | $1,258,820,490 | -$22,883,397 | $17.08 | 181 |
| 2025 Q2 | 75,621,323 | $949,023,010 | +$68,009,464 | $12.55 | 179 |
| 2025 Q1 | 70,389,436 | $838,494,320 | +$42,500,933 | $11.91 | 182 |
| 2024 Q4 | 66,481,090 | $973,230,925 | -$246,877 | $14.64 | 171 |
| 2024 Q3 | 66,502,275 | $834,701,900 | -$15,271,356 | $12.55 | 161 |
| 2024 Q2 | 68,183,439 | $580,274,097 | +$16,468,836 | $8.51 | 160 |
| 2024 Q1 | 67,744,225 | $712,627,244 | +$31,495,473 | $10.52 | 167 |
| 2023 Q4 | 64,825,365 | $673,552,112 | +$31,038,276 | $10.39 | 153 |
| 2023 Q3 | 62,318,186 | $395,187,634 | -$7,310,307 | $6.34 | 136 |
| 2023 Q2 | 63,418,288 | $547,948,381 | +$55,194,956 | $8.64 | 135 |
| 2023 Q1 | 56,707,830 | $512,639,046 | +$19,986,782 | $9.04 | 113 |
| 2022 Q4 | 55,146,033 | $433,446,373 | +$429,612,295 | $7.86 | 89 |
| 2022 Q3 | 78,394 | $482,000 | +$482,000 | $6.15 | 1 |