Ensysce Biosciences, Inc. - Common Stock, par value $0.0001 per share (ENSC) Institutional Ownership

13F Institutional Holders and Ownership History from Q4 2024 to Q4 2025

Type / Class
Equity / Common Stock, par value $0.0001 per share
Symbol
ENSC on Nasdaq
Shares outstanding
2,371,778
Price per share
$0.91
All holders as of 30 Sep 2025
Q3 2025
Total 13F shares
351,699
Total reported value
$833,709
% of total 13F portfolios
0%
Share change
+172,546
Value change
+$409,291
Number of holders
17
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Ensysce Biosciences, Inc. - Common Stock, par value $0.0001 per share (ENSC) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
PERCEPTIVE ADVISORS LLC 3.7% $264,331 86,666 0% Perceptive Advisors LLC 31 Mar 2025
Adage Capital Management, L.P. 3.2% -43% $167,353 74,711 0% Adage Capital Management, L.P. 30 Jun 2025

As of 30 Sep 2025, 17 institutional investors reported holding 351,699 shares of Ensysce Biosciences, Inc. - Common Stock, par value $0.0001 per share (ENSC). This represents 15% of the company’s total 2,371,778 outstanding shares.

Top 19 Institutional Shareholders

The largest institutional shareholders of Ensysce Biosciences, Inc. - Common Stock, par value $0.0001 per share (ENSC) together control 15% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
PERCEPTIVE ADVISORS LLC 3.7% 86,666 0% 0.01% $205,398
ADAGE CAPITAL PARTNERS GP, L.L.C. 3.1% 74,711 0% 0% $177,065
DRW Securities, LLC 2.9% 69,145 0.01% $163,873
VANGUARD GROUP INC 1.5% 36,708 0% $86,998
RENAISSANCE TECHNOLOGIES LLC 0.66% 15,574 0% $36,910
CITADEL ADVISORS LLC 0.61% 14,518 0% $34,408
Virtu Financial LLC 0.6% 14,222 0% $34,000
GEODE CAPITAL MANAGEMENT, LLC 0.55% 13,030 +28% 0% $30,880
XTX Topco Ltd 0.46% 10,957 0% $25,968
TRU INDEPENDENCE ASSET MANAGEMENT 2, LLC 0.44% 10,500 0.02% $24,885
FNY Investment Advisers, LLC 0.13% 3,000 0% 0% $7,000
Tower Research Capital LLC (TRC) 0.06% 1,348 -1.5% 0% $3,195
UBS Group AG 0.03% 800 +126% 0% $1,896
SBI Securities Co., Ltd. 0.02% 418 -82% 0% $991
BlackRock, Inc. 0% 65 0% 0% $154
BANK OF AMERICA CORP /DE/ 0% 24 +26% 0% $57
ASSETMARK, INC 0% 13 0% $31
MORGAN STANLEY 0% 0 -100% $0
RAYMOND JAMES FINANCIAL INC 0% 0 -100% $0

Institutional Holders of Ensysce Biosciences, Inc. - Common Stock, par value $0.0001 per share (ENSC) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 104,169 $95,075 +$24,085 $0.92 7
2025 Q3 351,699 $833,709 +$409,291 $2.37 17
2025 Q2 179,153 $398,820 -$449,714 $2.23 11
2025 Q1 353,153 $903,390 +$543,275 $2.56 9
2024 Q4 140,823 $1,145,879 +$1,145,879 $8.14 8