| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 15% | +13% | $12,946,856 | +$1,644,911 | 21,403,300 | +15% | T. Rowe Price Investment Management, Inc. | 30 Sep 2025 |
| Vestal Point Capital, LP | 9.9% | $4,485,000 | 11,500,000 | Vestal Point Capital, LP | 31 Dec 2024 | |||
| Alyeska Investment Group, L.P. | 5.8% | $2,615,924 | 6,707,497 | Alyeska Investment Group, L.P. | 31 Dec 2024 | |||
| ALEXANDRIA REAL ESTATE EQUITIES, INC. | 4.3% | $1,755,000 | 6,500,000 | Alexandria Real Estate Equities, Inc. | 11 Dec 2025 | |||
| Propel Bio Management, LLC | 4.2% | $1,564,002 | 6,015,394 | Propel Bio Management, LLC | 29 Dec 2025 | |||
| Venrock Healthcare Capital Partners III, L.P. | 4.1% | -58% | $2,171,407 | -$2,432,661 | 5,567,709 | -53% | Venrock Healthcare Capital Partners III, L.P. | 31 Mar 2025 |
| BlackRock, Inc. | 3.7% | -54% | $1,003,183 | -$783,523 | 5,219,475 | -44% | BlackRock, Inc. | 30 Jun 2025 |
| VANGUARD GROUP INC | 3.3% | -34% | $1,473,225 | -$359,492 | 4,734,013 | -20% | The Vanguard Group | 30 Jun 2025 |
| Schonfeld Strategic Advisors LLC | 3.3% | -53% | $1,823,678 | -$1,596,482 | 4,676,097 | -47% | Schonfeld Strategic Advisors LLC | 31 Mar 2025 |
| PERCEPTIVE ADVISORS LLC | 2.4% | $1,115,400 | 2,860,000 | Perceptive Advisors LLC | 31 Dec 2024 | |||
| MORGAN STANLEY | 2.5% | -64% | $1,114,983 | -$2,323,072 | 2,858,931 | -68% | Morgan Stanley | 31 Jan 2025 |
| FRANKLIN RESOURCES INC | 1.7% | -70% | $781,326 | -$1,871,029 | 2,003,400 | -71% | Franklin Resources, Inc. | 31 Dec 2024 |
| JANUS HENDERSON GROUP PLC | 0% | -104% | $13,958 | -$4,706,957 | 35,791 | -100% | JANUS HENDERSON GROUP PLC | 31 Dec 2024 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 15% | 21,403,300 | +15% | 0.01% | $12,842,000 |
| Vestal Point Capital, LP | 9.9% | 14,250,000 | +24% | 0.39% | $8,619,825 |
| Propel Bio Management, LLC | 7.9% | 11,285,420 | 0% | 6.8% | $6,826,551 |
| Knoll Capital Management, LLC | 5.4% | 7,799,687 | 0% | 2.5% | $4,711,010 |
| VANGUARD GROUP INC | 3.6% | 5,102,689 | +7.8% | 0% | $3,087,126 |
| Simplify Asset Management Inc. | 3.1% | 4,487,505 | 0% | 0.06% | $2,714,492 |
| BlackRock, Inc. | 2.7% | 3,843,733 | -26% | 0% | $2,325,074 |
| PNC Financial Services Group, Inc. | 2% | 2,901,184 | 0% | $1,755,216 | |
| Pathstone Holdings, LLC | 1.8% | 2,643,540 | 0% | 0.01% | $1,599,077 |
| MARSHALL WACE, LLP | 1.8% | 2,542,688 | +65% | 0% | $1,525,612 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.5% | 2,211,629 | +83% | 0% | $1,337,814 |
| Rock Springs Capital Management LP | 1.4% | 2,075,991 | 0% | 0.07% | $1,255,767 |
| FRANKLIN RESOURCES INC | 1.4% | 2,003,338 | 0% | 0% | $1,211,819 |
| MILLENNIUM MANAGEMENT LLC | 1.3% | 1,907,214 | -1.9% | 0% | $1,153,674 |
| UBS Group AG | 1.3% | 1,905,625 | +129% | 0% | $1,152,903 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.89% | 1,278,156 | +32% | 0% | $773,417 |
| Qube Research & Technologies Ltd | 0.81% | 1,167,269 | -36% | 0% | $706,081 |
| MORGAN STANLEY | 0.5% | 713,314 | +108% | 0% | $431,484 |
| Hudson Bay Capital Management LP | 0.47% | 673,764 | 0% | $407,560 | |
| DEUTSCHE BANK AG\ | 0.43% | 622,226 | -0% | 0% | $379,558 |
| STATE STREET CORP | 0.36% | 518,518 | +47% | 0% | $313,652 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0.33% | 477,157 | -19% | 0% | $288,632 |
| Rockefeller Capital Management L.P. | 0.27% | 391,897 | 0% | $237,058 | |
| Hennion & Walsh Asset Management, Inc. | 0.2% | 282,848 | -1.8% | 0.01% | $171,095 |
| Birchview Capital, LP | 0.16% | 225,000 | -20% | 0.1% | $136,103 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 41,748 | $4,000 | +$2,428 | $0.0958 | 1 |
| 2025 Q3 | 94,763,328 | $57,199,408 | +$5,274,176 | $0.6049 | 69 |
| 2025 Q2 | 88,058,885 | $27,371,087 | -$7,459,469 | $0.3111 | 72 |
| 2025 Q1 | 106,044,815 | $51,845,704 | -$6,334,916 | $0.4889 | 89 |
| 2024 Q4 | 115,065,005 | $98,537,797 | -$63,025,089 | $0.8562 | 116 |
| 2024 Q3 | 112,721,874 | $960,819,113 | +$78,176,113 | $8.50 | 125 |
| 2024 Q2 | 103,226,978 | $481,702,267 | +$36,985,908 | $4.67 | 92 |
| 2024 Q1 | 93,958,967 | $638,614,949 | +$241,302,453 | $6.80 | 88 |
| 2023 Q4 | 61,449,532 | $205,844,085 | +$29,840,415 | $3.35 | 83 |
| 2023 Q3 | 42,970,428 | $106,996,842 | +$29,101,733 | $2.49 | 54 |
| 2023 Q2 | 31,465,661 | $40,275,555 | +$15,796,729 | $1.28 | 38 |
| 2023 Q1 | 19,276,965 | $15,634,509 | -$232,317 | $0.8111 | 34 |
| 2022 Q4 | 19,679,561 | $15,064,959 | -$2,201,503 | $0.7600 | 37 |
| 2022 Q3 | 22,671,560 | $21,085,673 | -$3,749,758 | $0.9301 | 38 |
| 2022 Q2 | 26,706,667 | $25,318,845 | +$12,989,524 | $0.9481 | 46 |
| 2022 Q1 | 12,347,239 | $26,037,310 | -$34,487,329 | $2.11 | 68 |
| 2021 Q4 | 14,922,342 | $133,548,279 | -$7,772,547 | $8.95 | 67 |
| 2021 Q3 | 15,108,904 | $250,903,236 | -$6,255,939 | $16.60 | 66 |
| 2021 Q2 | 15,367,633 | $319,342,764 | +$10,194,603 | $20.78 | 68 |
| 2021 Q1 | 14,854,223 | $278,593,752 | +$51,374,327 | $18.76 | 66 |
| 2020 Q4 | 12,104,777 | $266,428,658 | -$1,610,604 | $22.01 | 67 |
| 2020 Q3 | 12,195,771 | $253,182,315 | -$6,258,655 | $20.76 | 66 |
| 2020 Q2 | 11,427,491 | $412,583,649 | +$78,213,106 | $36.15 | 71 |
| 2020 Q1 | 9,645,977 | $315,329,165 | +$155,281,170 | $32.69 | 62 |
| 2019 Q4 | 4,991,742 | $136,175,281 | +$71,201,517 | $27.28 | 45 |
| 2019 Q3 | 2,395,520 | $26,326,659 | +$2,265,568 | $10.99 | 29 |
| 2019 Q2 | 2,195,975 | $18,095,000 | +$18,095,000 | $8.24 | 13 |