| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 15% | +13% | $12,946,856 | +$1,644,911 | 21,403,300 | +15% | T. Rowe Price Investment Management, Inc. | 30 Sep 2025 |
| Alyeska Investment Group, L.P. | 5.8% | $2,615,924 | 6,707,497 | Alyeska Investment Group, L.P. | 31 Dec 2024 | |||
| ALEXANDRIA REAL ESTATE EQUITIES, INC. | 4.3% | $1,755,000 | 6,500,000 | Alexandria Real Estate Equities, Inc. | 11 Dec 2025 | |||
| Propel Bio Management, LLC | 4.2% | $1,564,002 | 6,015,394 | Propel Bio Management, LLC | 29 Dec 2025 | |||
| Venrock Healthcare Capital Partners III, L.P. | 4.1% | -58% | $2,171,407 | -$2,432,661 | 5,567,709 | -53% | Venrock Healthcare Capital Partners III, L.P. | 31 Mar 2025 |
| BlackRock, Inc. | 3.7% | -54% | $1,003,183 | -$783,523 | 5,219,475 | -44% | BlackRock, Inc. | 30 Jun 2025 |
| VANGUARD GROUP INC | 3.3% | -34% | $1,473,225 | -$359,492 | 4,734,013 | -20% | The Vanguard Group | 30 Jun 2025 |
| Schonfeld Strategic Advisors LLC | 3.3% | -53% | $1,823,678 | -$1,596,482 | 4,676,097 | -47% | Schonfeld Strategic Advisors LLC | 31 Mar 2025 |
| PERCEPTIVE ADVISORS LLC | 2.4% | $1,115,400 | 2,860,000 | Perceptive Advisors LLC | 31 Dec 2024 | |||
| MORGAN STANLEY | 2.5% | -64% | $1,114,983 | -$2,323,072 | 2,858,931 | -68% | Morgan Stanley | 31 Jan 2025 |
| FRANKLIN RESOURCES INC | 1.7% | -70% | $781,326 | -$1,871,029 | 2,003,400 | -71% | Franklin Resources, Inc. | 31 Dec 2024 |
| JANUS HENDERSON GROUP PLC | 0% | -104% | $13,958 | -$4,706,957 | 35,791 | -100% | JANUS HENDERSON GROUP PLC | 31 Dec 2024 |
As of 31 Dec 2025, 50 institutional investors reported holding 58,883,039 shares of Applied Therapeutics, Inc. - Common Stock, par value $0.0001 per share (APLT). This represents 41% of the company’s total 143,223,667 outstanding shares.
The largest institutional shareholders of Applied Therapeutics, Inc. - Common Stock, par value $0.0001 per share (APLT) together control 40% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 15% | 21,747,844 | +1.6% | 0% | $2,175,000 |
| VANGUARD GROUP INC | 4.4% | 6,353,018 | +25% | 0% | $635,302 |
| Knoll Capital Management, LLC | 4.2% | 6,050,000 | -22% | 0.28% | $605,000 |
| DELTEC ASSET MANAGEMENT LLC | 2.7% | 3,847,449 | 0.06% | $384,745 | |
| BlackRock, Inc. | 2.3% | 3,251,462 | -15% | 0% | $325,146 |
| RENAISSANCE TECHNOLOGIES LLC | 1.9% | 2,706,156 | 0% | $270,616 | |
| Pathstone Holdings, LLC | 1.8% | 2,643,540 | 0% | 0% | $305,065 |
| JANE STREET GROUP, LLC | 1.5% | 2,087,404 | 0% | $208,740 | |
| GEODE CAPITAL MANAGEMENT, LLC | 1% | 1,492,903 | +17% | 0% | $149,330 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0.85% | 1,211,629 | -45% | 0% | $121,163 |
| MILLENNIUM MANAGEMENT LLC | 0.73% | 1,051,846 | -45% | 0% | $105,185 |
| UBS Group AG | 0.5% | 718,924 | -62% | 0% | $71,892 |
| DEUTSCHE BANK AG\ | 0.43% | 622,226 | 0% | 0% | $62,223 |
| Graham Capital Management, L.P. | 0.4% | 572,759 | 0% | $57,276 | |
| STATE STREET CORP | 0.39% | 558,178 | +7.6% | 0% | $55,818 |
| Virtu Financial LLC | 0.35% | 496,288 | +873% | 0% | $50,000 |
| Lynx1 Capital Management LP | 0.29% | 410,500 | 0.01% | $41,050 | |
| MARSHALL WACE, LLP | 0.24% | 337,389 | -87% | 0% | $33,739 |
| Hennion & Walsh Asset Management, Inc. | 0.23% | 327,137 | +16% | 0% | $32,714 |
| EQUITEC PROPRIETARY MARKETS, LLC | 0.21% | 300,600 | 0.14% | $30,060 | |
| Bank of New York Mellon Corp | 0.18% | 253,573 | +219% | 0% | $25,357 |
| NORTHERN TRUST CORP | 0.17% | 245,144 | +41% | 0% | $24,514 |
| Rockefeller Capital Management L.P. | 0.17% | 241,897 | -38% | 0% | $24,190 |
| GTS SECURITIES LLC | 0.14% | 200,009 | 0% | $20,001 | |
| MORGAN STANLEY | 0.12% | 178,474 | -75% | 0% | $17,847 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 58,883,039 | $5,929,909 | -$23,764,068 | $0.10 | 50 |
| 2025 Q3 | 94,763,328 | $57,199,408 | +$5,274,176 | $0.60 | 69 |
| 2025 Q2 | 88,058,885 | $27,371,087 | -$7,459,469 | $0.31 | 72 |
| 2025 Q1 | 106,044,815 | $51,845,704 | -$6,334,916 | $0.49 | 89 |
| 2024 Q4 | 115,065,005 | $98,537,797 | -$63,025,089 | $0.86 | 116 |
| 2024 Q3 | 112,721,874 | $960,819,113 | +$78,176,113 | $8.50 | 125 |
| 2024 Q2 | 103,226,978 | $481,702,267 | +$36,985,908 | $4.67 | 92 |
| 2024 Q1 | 93,958,967 | $638,614,949 | +$241,302,453 | $6.80 | 88 |
| 2023 Q4 | 61,449,532 | $205,844,085 | +$29,840,415 | $3.35 | 83 |
| 2023 Q3 | 42,970,428 | $106,996,842 | +$29,101,733 | $2.49 | 54 |
| 2023 Q2 | 31,465,661 | $40,275,555 | +$15,796,729 | $1.28 | 38 |
| 2023 Q1 | 19,276,965 | $15,634,509 | -$232,317 | $0.81 | 34 |
| 2022 Q4 | 19,679,561 | $15,064,959 | -$2,201,503 | $0.76 | 37 |
| 2022 Q3 | 22,671,560 | $21,085,673 | -$3,749,758 | $0.93 | 38 |
| 2022 Q2 | 26,706,667 | $25,318,845 | +$12,989,524 | $0.95 | 46 |
| 2022 Q1 | 12,347,239 | $26,037,310 | -$34,487,329 | $2.11 | 68 |
| 2021 Q4 | 14,922,342 | $133,548,279 | -$7,772,547 | $8.95 | 67 |
| 2021 Q3 | 15,108,904 | $250,903,236 | -$6,255,939 | $16.60 | 66 |
| 2021 Q2 | 15,367,633 | $319,342,764 | +$10,194,603 | $20.78 | 68 |
| 2021 Q1 | 14,854,223 | $278,593,752 | +$51,374,327 | $18.76 | 66 |
| 2020 Q4 | 12,104,777 | $266,428,658 | -$1,610,604 | $22.01 | 67 |
| 2020 Q3 | 12,195,771 | $253,182,315 | -$6,258,655 | $20.76 | 66 |
| 2020 Q2 | 11,427,491 | $412,583,649 | +$78,213,106 | $36.15 | 71 |
| 2020 Q1 | 9,645,977 | $315,329,165 | +$155,281,170 | $32.69 | 62 |
| 2019 Q4 | 4,991,742 | $136,175,281 | +$71,201,517 | $27.28 | 45 |
| 2019 Q3 | 2,395,520 | $26,326,659 | +$2,265,568 | $10.99 | 29 |
| 2019 Q2 | 2,195,975 | $18,095,000 | +$18,095,000 | $8.24 | 13 |