| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 12.4% | +34.4% | $65.5M | $16.3M | 20.5M | +33.3% | FMR LLC | Oct 31, 2025 |
| Venrock Healthcare Capital Partners III, L.P. | 9.4% | +15% | $49.6M | $8.2M | 15.6M | +19.8% | Venrock Healthcare Capital Partners III, L.P. | Sep 30, 2025 |
| Longitude Capital Partners V, LLC | 7.3% | $8.19M | 11.5M | Longitude Capital Partners V, LLC | May 13, 2025 | |||
| TANG CAPITAL MANAGEMENT LLC | 7% | -17.5% | $27.4M | $10.8M | 11.1M | +64.7% | TANG CAPITAL MANAGEMENT, LLC | Jun 30, 2025 |
| PERCEPTIVE ADVISORS LLC | 5.9% | $22.5M | 9.68M | Perceptive Advisors LLC | Aug 14, 2025 | |||
| VANGUARD GROUP INC | 5.95% | $21.3M | 9.38M | The Vanguard Group | Jun 30, 2025 | |||
| ORBIMED ADVISORS LLC | 5.4% | $21M | 8.46M | OrbiMed Advisors LLC | Jun 30, 2025 | |||
| BIOTECHNOLOGY VALUE FUND L P | 3.5% | -47.1% | $17.3M | -$17.3M | 5.77M | -50% | BVF PARTNERS L P/IL | Jul 3, 2025 |
| Point72 Asset Management, L.P. | 2.5% | -52% | $13M | -$12.8M | 4.07M | -49.7% | Point72 Asset Management, L.P. | Sep 30, 2025 |
| Seven Fleet Partners LP | 0.2% | $268K | 377K | Seven Fleet Partners LP | May 13, 2025 | |||
| Seven Fleet Capital Management LP | 0.02% | $156K | 48.9K | Seven Fleet Master Fund LP | Sep 30, 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 137M | $438M | +$24.4M | $3.19 | 101 |
| 2025 Q2 | 133M | $303M | +$214M | $2.27 | 82 |
| 2025 Q1 | 45.2M | $28.7M | -$1.51M | $0.64 | 63 |
| 2024 Q4 | 46.7M | $48.1M | -$6.38M | $1.03 | 68 |
| 2024 Q3 | 51.2M | $60.4M | +$481K | $1.18 | 70 |
| 2024 Q2 | 50.7M | $61.9M | +$882K | $1.22 | 73 |
| 2024 Q1 | 44.3M | $96.6M | +$25.5M | $2.18 | 84 |
| 2023 Q4 | 32.6M | $50.6M | +$410K | $1.55 | 66 |
| 2023 Q3 | 32.4M | $41.8M | -$2.42M | $1.29 | 61 |
| 2023 Q2 | 34.1M | $58.7M | -$2.38M | $1.72 | 66 |
| 2023 Q1 | 35.6M | $53.8M | -$933K | $1.51 | 74 |
| 2022 Q4 | 36M | $120M | -$725K | $1.60 | 77 |
| 2022 Q3 | 36.3M | $52.6M | -$19M | $1.45 | 76 |
| 2022 Q2 | 45.6M | $83.4M | -$17.8M | $1.83 | 86 |
| 2022 Q1 | 53.7M | $143M | -$1.75M | $2.67 | 112 |
| 2021 Q4 | 54.3M | $235M | -$5.31M | $4.33 | 106 |
| 2021 Q3 | 54M | $275M | -$17.3M | $5.09 | 112 |
| 2021 Q2 | 56.7M | $359M | +$4.31M | $6.33 | 119 |
| 2021 Q1 | 54.6M | $422M | +$130M | $7.73 | 123 |
| 2020 Q4 | 38M | $249M | +$5.58M | $6.55 | 123 |
| 2020 Q3 | 36.8M | $245M | -$11.6M | $6.65 | 128 |
| 2020 Q2 | 37.8M | $315M | +$15.5M | $8.33 | 133 |
| 2020 Q1 | 36.1M | $277M | +$245K | $7.67 | 113 |
| 2019 Q4 | 36M | $299M | -$9.33M | $8.31 | 119 |
| 2019 Q3 | 35.8M | $264M | -$1.38M | $7.38 | 111 |
| 2019 Q2 | 35.6M | $400M | -$8.09M | $11.22 | 108 |
| 2019 Q1 | 36.9M | $397M | -$12.8M | $10.75 | 110 |
| 2018 Q4 | 37.8M | $570M | -$2.75M | $15.10 | 109 |
| 2018 Q3 | 37.8M | $697M | +$95.6M | $18.50 | 120 |
| 2018 Q2 | 32.3M | $739M | +$66.1M | $22.86 | 140 |
| 2018 Q1 | 28.6M | $814M | +$73.3M | $28.45 | 135 |
| 2017 Q4 | 30.1M | $637M | +$56M | $21.11 | 119 |
| 2017 Q3 | 24.2M | $441M | +$42M | $18.17 | 97 |
| 2017 Q2 | 22.1M | $343M | +$44.1M | $15.50 | 89 |
| 2017 Q1 | 19.2M | $332M | +$58.3M | $17.27 | 86 |
| 2016 Q4 | 16.9M | $185M | +$15M | $10.99 | 68 |
| 2016 Q3 | 19.7M | $243M | +$18.1M | $15.68 | 61 |
| 2016 Q2 | 18.8M | $149M | +$16M | $10.21 | 59 |
| 2016 Q1 | 17.7M | $228M | +$3.39M | $12.90 | 49 |
| 2015 Q4 | 12.5M | $258M | +$240M | $20.87 | 47 |