| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 12% | +34% | $65,458,695 | +$16,344,817 | 20,519,967 | +33% | FMR LLC | 31 Oct 2025 |
| Venrock Healthcare Capital Partners III, L.P. | 9.4% | +15% | $49,641,185 | +$8,195,110 | 15,561,500 | +20% | Venrock Healthcare Capital Partners III, L.P. | 30 Sep 2025 |
| Longitude Capital Partners V, LLC | 7.3% | $8,192,307 | 11,538,461 | Longitude Capital Partners V, LLC | 13 May 2025 | |||
| TANG CAPITAL MANAGEMENT LLC | 7% | -18% | $27,442,842 | +$10,782,636 | 11,065,662 | +65% | TANG CAPITAL MANAGEMENT, LLC | 30 Jun 2025 |
| PERCEPTIVE ADVISORS LLC | 5.9% | $22,458,029 | 9,680,185 | Perceptive Advisors LLC | 14 Aug 2025 | |||
| VANGUARD GROUP INC | 6% | $21,292,132 | 9,379,794 | The Vanguard Group | 30 Jun 2025 | |||
| ORBIMED ADVISORS LLC | 5.4% | $20,984,520 | 8,461,500 | OrbiMed Advisors LLC | 30 Jun 2025 | |||
| BIOTECHNOLOGY VALUE FUND L P | 3.5% | -47% | $17,250,001 | -$17,250,001 | 5,769,231 | -50% | BVF PARTNERS L P/IL | 03 Jul 2025 |
| Point72 Asset Management, L.P. | 2.5% | -52% | $12,978,754 | -$12,811,193 | 4,068,575 | -50% | Point72 Asset Management, L.P. | 30 Sep 2025 |
| Seven Fleet Partners LP | 0.2% | $267,784 | 377,161 | Seven Fleet Partners LP | 13 May 2025 | |||
| Seven Fleet Capital Management LP | 0.02% | $155,985 | 48,898 | Seven Fleet Master Fund LP | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| VR ADVISER, LLC | 9.4% | 15,561,500 | +11% | 2.8% | $49,641,185 |
| FMR LLC | 9.3% | 15,396,200 | +67% | 0% | $49,113,878 |
| TANG CAPITAL MANAGEMENT LLC | 6.7% | 11,065,662 | 0% | 1.4% | $35,299,462 |
| PERCEPTIVE ADVISORS LLC | 5.8% | 9,680,185 | +38% | 0.9% | $30,879,790 |
| VANGUARD GROUP INC | 5.4% | 8,947,807 | -4.6% | 0% | $28,543,505 |
| ORBIMED ADVISORS LLC | 5.1% | 8,461,500 | 0% | 0.65% | $26,992,185 |
| Commodore Capital LP | 4.6% | 7,692,300 | 0% | 1.2% | $24,538,437 |
| BAKER BROS. ADVISORS LP | 2.6% | 4,250,826 | +22% | 0.1% | $13,560,135 |
| Point72 Asset Management, L.P. | 2.5% | 4,068,575 | -50% | 0.03% | $12,978,754 |
| ADAR1 Capital Management, LLC | 2.4% | 4,045,414 | +31% | 1.3% | $12,904,871 |
| Balyasny Asset Management L.P. | 2.4% | 3,913,081 | +37% | 0.03% | $12,482,728 |
| Kynam Capital Management, LP | 2.2% | 3,646,503 | +69% | 0.87% | $11,632,345 |
| RTW INVESTMENTS, LP | 2.1% | 3,461,500 | 0% | 0.14% | $11,042,185 |
| Ikarian Capital, LLC | 2% | 3,372,616 | 2.4% | $10,758,645 | |
| Vivo Capital, LLC | 1.7% | 2,884,615 | -50% | 0.74% | $9,201,922 |
| RA CAPITAL MANAGEMENT, L.P. | 1.6% | 2,661,331 | 0% | 0.1% | $8,489,646 |
| RENAISSANCE TECHNOLOGIES LLC | 1.5% | 2,545,260 | +37% | 0.01% | $8,119,379 |
| BlackRock, Inc. | 1.4% | 2,381,912 | -0.27% | 0% | $7,598,299 |
| Woodline Partners LP | 1.4% | 2,337,005 | +0% | 0.04% | $7,455,046 |
| CITADEL ADVISORS LLC | 1.1% | 1,800,435 | +2006% | 0% | $5,743,387 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.95% | 1,569,298 | -10% | 0% | $5,008,010 |
| MILLENNIUM MANAGEMENT LLC | 0.84% | 1,386,863 | +494% | 0% | $4,424,093 |
| Financial Engines Advisors L.L.C. | 0.83% | 1,381,357 | 0.01% | $4,406,529 | |
| BOOTHBAY FUND MANAGEMENT, LLC | 0.75% | 1,237,057 | 0.1% | $3,946,212 | |
| MARSHALL WACE, LLP | 0.67% | 1,104,993 | -53% | 0% | $3,524,928 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 645,805 | $2,750,885 | -$358,774 | $4.26 | 2 |
| 2025 Q3 | 137,376,737 | $438,231,708 | +$24,416,720 | $3.19 | 101 |
| 2025 Q2 | 133,305,109 | $302,602,132 | +$213,797,054 | $2.27 | 82 |
| 2025 Q1 | 45,180,958 | $28,723,084 | -$1,507,772 | $0.64 | 63 |
| 2024 Q4 | 46,714,805 | $48,111,898 | -$6,381,441 | $1.03 | 68 |
| 2024 Q3 | 51,193,741 | $60,427,306 | +$480,690 | $1.18 | 69 |
| 2024 Q2 | 50,687,257 | $61,863,474 | +$334,609 | $1.22 | 73 |
| 2024 Q1 | 44,548,308 | $97,118,414 | +$26,024,246 | $2.18 | 85 |
| 2023 Q4 | 32,640,376 | $50,592,909 | +$410,206 | $1.55 | 66 |
| 2023 Q3 | 32,393,313 | $41,785,804 | -$2,418,556 | $1.29 | 61 |
| 2023 Q2 | 34,120,916 | $58,688,106 | -$2,378,087 | $1.72 | 66 |
| 2023 Q1 | 35,594,054 | $53,751,153 | -$933,381 | $1.51 | 74 |
| 2022 Q4 | 35,979,014 | $120,192,376 | -$724,794 | $1.60 | 77 |
| 2022 Q3 | 36,281,610 | $52,604,898 | -$18,986,577 | $1.45 | 76 |
| 2022 Q2 | 45,579,430 | $83,410,352 | -$17,825,825 | $1.83 | 86 |
| 2022 Q1 | 53,661,262 | $143,355,949 | -$1,754,233 | $2.67 | 112 |
| 2021 Q4 | 54,342,875 | $235,299,521 | -$5,313,006 | $4.33 | 106 |
| 2021 Q3 | 53,978,233 | $274,775,521 | -$17,338,127 | $5.09 | 111 |
| 2021 Q2 | 56,688,576 | $358,879,555 | +$4,313,452 | $6.33 | 119 |
| 2021 Q1 | 54,613,642 | $422,156,729 | +$130,257,296 | $7.73 | 123 |
| 2020 Q4 | 37,995,365 | $248,881,255 | +$5,576,359 | $6.55 | 123 |
| 2020 Q3 | 36,841,081 | $245,069,950 | -$11,639,890 | $6.65 | 128 |
| 2020 Q2 | 37,758,348 | $314,514,192 | +$15,532,613 | $8.33 | 133 |
| 2020 Q1 | 36,087,916 | $276,879,388 | +$244,869 | $7.67 | 113 |
| 2019 Q4 | 36,001,618 | $299,160,261 | -$9,333,104 | $8.31 | 119 |
| 2019 Q3 | 35,837,109 | $264,433,175 | -$1,377,891 | $7.38 | 111 |
| 2019 Q2 | 35,647,194 | $399,598,509 | -$8,094,164 | $11.22 | 108 |
| 2019 Q1 | 36,897,584 | $396,629,592 | -$12,805,896 | $10.75 | 110 |
| 2018 Q4 | 37,768,617 | $569,884,178 | -$2,745,916 | $15.10 | 108 |
| 2018 Q3 | 37,780,542 | $697,391,587 | +$95,602,749 | $18.50 | 119 |
| 2018 Q2 | 32,308,752 | $738,633,935 | +$66,042,910 | $22.86 | 139 |
| 2018 Q1 | 28,622,740 | $814,197,912 | +$73,379,749 | $28.45 | 136 |
| 2017 Q4 | 30,146,848 | $636,945,631 | +$56,049,834 | $21.11 | 119 |
| 2017 Q3 | 24,242,512 | $440,733,363 | +$42,038,227 | $18.17 | 97 |
| 2017 Q2 | 22,105,676 | $342,719,825 | +$44,092,931 | $15.50 | 89 |
| 2017 Q1 | 19,204,130 | $331,600,145 | +$58,337,064 | $17.27 | 86 |
| 2016 Q4 | 16,857,707 | $185,279,386 | +$14,954,410 | $10.99 | 68 |
| 2016 Q3 | 19,725,140 | $242,759,481 | +$18,076,577 | $15.68 | 61 |
| 2016 Q2 | 18,845,409 | $149,178,103 | +$16,034,432 | $10.21 | 59 |
| 2016 Q1 | 12,778,869 | $164,816,000 | +$3,379,204 | $12.90 | 47 |
| 2015 Q4 | 12,469,279 | $258,260,359 | +$239,918,359 | $20.87 | 47 |