Insider Trading & Ownership of PERCEPTIVE ADVISORS LLC

Location
New York, NY
Summary
The estimated value of insider holdings of PERCEPTIVE ADVISORS LLC is at least $926M dollars as of 23 Dec 2025. PERCEPTIVE ADVISORS LLC is the 10%+ Owner of Crinetics Pharmaceuticals, Inc. and owns shares of Crinetics Pharmaceuticals, Inc. (CRNX) stock worth about $200M. PERCEPTIVE ADVISORS LLC is the 10%+ Owner of VBI Vaccines Inc/BC and owns shares of VBI Vaccines Inc/BC stock worth about $137M. PERCEPTIVE ADVISORS LLC is the 10%+ Owner of SOLENO THERAPEUTICS INC and owns shares of SOLENO THERAPEUTICS INC (SLNO) stock worth about $112M. PERCEPTIVE ADVISORS LLC is the 10%+ Owner of ALBIREO PHARMA, INC. and owns shares of ALBIREO PHARMA, INC. stock worth about $85M. PERCEPTIVE ADVISORS LLC is the Director of Astria Therapeutics, Inc. and owns shares of Astria Therapeutics, Inc. (ATXS) stock worth about $67.2M. PERCEPTIVE ADVISORS LLC is the 10%+ Owner of ADMA BIOLOGICS, INC. and owns shares of ADMA BIOLOGICS, INC. (ADMA) stock worth about $59.9M. PERCEPTIVE ADVISORS LLC is the 10%+ Owner of Verrica Pharmaceuticals Inc. and owns shares of Verrica Pharmaceuticals Inc. (VRCA) stock worth about $51.4M. PERCEPTIVE ADVISORS LLC is the Director, 10%+ Owner of MeiraGTx Holdings plc and owns shares of MeiraGTx Holdings plc (MGTX) stock worth about $50.1M. PERCEPTIVE ADVISORS LLC is the Director, 10%+ Owner of Solid Biosciences Inc. and owns shares of Solid Biosciences Inc. (SLDB) stock worth about $47.7M. PERCEPTIVE ADVISORS LLC is the 10%+ Owner of Aldeyra Therapeutics, Inc. and owns shares of Aldeyra Therapeutics, Inc. (ALDX) stock worth about $27.8M. PERCEPTIVE ADVISORS LLC is the 10%+ Owner of Orchestra BioMed Holdings, Inc. and owns shares of Orchestra BioMed Holdings, Inc. (OBIO) stock worth about $18.7M. PERCEPTIVE ADVISORS LLC is the 10%+ Owner of AGILE THERAPEUTICS INC and owns shares of AGILE THERAPEUTICS INC stock worth about $18.4M. PERCEPTIVE ADVISORS LLC is the Director, 10%+ Owner of Athira Pharma, Inc. and owns shares of Athira Pharma, Inc. (ATHA) stock worth about $17.7M. PERCEPTIVE ADVISORS LLC is the 10%+ Owner of VYNE Therapeutics Inc. and owns shares of VYNE Therapeutics Inc. (VYNE) stock worth about $11.3M. PERCEPTIVE ADVISORS LLC is the Former 10% Owner of CARGO Therapeutics, Inc. and owns shares of CARGO Therapeutics, Inc. (CRGX) stock worth about $5M. PERCEPTIVE ADVISORS LLC is the 10%+ Owner of Acrivon Therapeutics, Inc. and owns shares of Acrivon Therapeutics, Inc. (ACRV) stock worth about $4.16M. PERCEPTIVE ADVISORS LLC is the Director, 10%+ Owner of Adagio Medical Holdings, Inc. and owns shares of Adagio Medical Holdings, Inc. (ADGM) stock worth about $3.51M. PERCEPTIVE ADVISORS LLC is the 10%+ Owner of Rain Therapeutics Inc. and owns shares of Rain Oncology Inc. stock worth about $3.01M. PERCEPTIVE ADVISORS LLC is the 10%+ Owner of IsoPlexis Corp and owns shares of IsoPlexis Corp stock worth about $2.97M. PERCEPTIVE ADVISORS LLC is the 10%+ Owner of CHEMBIO DIAGNOSTICS, INC. and owns shares of CHEMBIO DIAGNOSTICS, INC. stock worth about $1.65M. PERCEPTIVE ADVISORS LLC is the 10%+ Owner of Quotient Ltd and owns shares of Quotient Ltd stock worth about $636K. PERCEPTIVE ADVISORS LLC is the Director, 10%+ Owner of LianBio and owns shares of LianBio (LIANY) stock worth about $81.3K. PERCEPTIVE ADVISORS LLC is the 10%+ Owner of Lyra Therapeutics, Inc. and owns shares of Lyra Therapeutics, Inc. (LYRA) stock worth about $54.7K.
Signature
/s/ Joseph Edelman - for Perceptive Life Sciences Master Fund Ltd., By: Perceptive Advisors LLC, its investment manager, By: Joseph Edelman, its managing member
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Ownership of PERCEPTIVE ADVISORS LLC

Symbol Company Relationship Holdings Value Past Year Net Change Change % Report Period
CRNX Crinetics Pharmaceuticals, Inc. 10%+ Owner $200M 18 Apr 2022
VBIV VBI Vaccines Inc/BC 10%+ Owner $137M 04 Apr 2023
SLNO SOLENO THERAPEUTICS INC 10%+ Owner $112M 26 Sep 2023
ALBO ALBIREO PHARMA, INC. 10%+ Owner $85M 11 Oct 2022
ATXS Astria Therapeutics, Inc. Director $67.2M 01 Feb 2024
ADMA ADMA BIOLOGICS, INC. 10%+ Owner $59.9M 28 Sep 2021
VRCA Verrica Pharmaceuticals Inc. 10%+ Owner $51.4M 27 Dec 2023
MGTX MeiraGTx Holdings plc Director, 10%+ Owner $50.1M 12 Jun 2025
SLDB Solid Biosciences Inc. Director, 10%+ Owner $47.7M +$20.2M +73.2% 12 Jun 2025
ALDX Aldeyra Therapeutics, Inc. 10%+ Owner $27.8M 03 Apr 2025
OBIO Orchestra BioMed Holdings, Inc. 10%+ Owner $18.7M +$6.05M +47.9% 01 Aug 2025
AGRX AGILE THERAPEUTICS INC 10%+ Owner $18.4M 13 Oct 2021
ATHA Athira Pharma, Inc. Director, 10%+ Owner $17.7M 23 Dec 2025
VYNE VYNE Therapeutics Inc. 10%+ Owner $11.3M 16 Aug 2021
CRGX CARGO Therapeutics, Inc. Former 10% Owner $5M 14 Nov 2023
ACRV Acrivon Therapeutics, Inc. 10%+ Owner $4.16M -$3.76M -47.5% 30 Apr 2025
ADGM Adagio Medical Holdings, Inc. Director, 10%+ Owner $3.51M +$3.51M 20 Oct 2025
RAIN Rain Oncology Inc. 10%+ Owner $3.01M 07 Oct 2021
ISO IsoPlexis Corp 10%+ Owner $2.97M 12 Oct 2021
CEMI CHEMBIO DIAGNOSTICS, INC. 10%+ Owner $1.65M 04 Apr 2023
QTNT Quotient Ltd 10%+ Owner $636K 31 Oct 2022
LIANY LianBio Director, 10%+ Owner $81.3K 15 Feb 2024
LYRA Lyra Therapeutics, Inc. 10%+ Owner $54.7K -$527K -90.6% 11 Nov 2025
CERE Cerevel Therapeutics Holdings, Inc. Director $0 20 Feb 2024
LABP Landos Biopharma, Inc. 10%+ Owner 10 Jan 2023
LPTX LEAP THERAPEUTICS, INC. 10%+ Owner 24 Sep 2021
NAUT Nautilus Biotechnology, Inc. Director, 10%+ Owner 14 Jun 2024
VAPO VAPOTHERM INC 10%+ Owner 17 Jun 2024

Insider Transactions Reported by PERCEPTIVE ADVISORS LLC:

Sym Company Class Transaction % Value $ * Price $ Shares Shares After Date Ownership
* An asterisk sign (*) next to the price indicates that the price is likely invalid.