| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| SABBY MANAGEMENT, LLC | 9.9% | $628,817 | 175,158 | SABBY MANAGEMENT, LLC | 31 Dec 2025 |
As of 30 Sep 2025, 25 institutional investors reported holding 448,588 shares of Lyra Therapeutics, Inc. - Common Stock (LYRA). This represents 25% of the company’s total 1,769,273 outstanding shares.
The largest institutional shareholders of Lyra Therapeutics, Inc. - Common Stock (LYRA) together control 25% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 13% | 229,382 | -10% | 0.04% | $1,497,864 |
| SABBY MANAGEMENT, LLC | 7.2% | 127,624 | +1.5% | 4.3% | $832,874 |
| VANGUARD GROUP INC | 1.6% | 28,754 | -1.5% | 0% | $189,489 |
| Ikarian Capital, LLC | 1.2% | 21,161 | 0% | 0.03% | $139,452 |
| CITADEL ADVISORS LLC | 1.1% | 19,484 | 0% | $128,400 | |
| GEODE CAPITAL MANAGEMENT, LLC | 0.62% | 10,986 | 0% | 0% | $72,412 |
| UBS Group AG | 0.23% | 4,001 | +199950% | 0% | $26,111 |
| BlackRock, Inc. | 0.1% | 1,690 | 0% | 0% | $11,029 |
| ROYAL BANK OF CANADA | 0.07% | 1,325 | +20% | 0% | $9,000 |
| MORGAN STANLEY | 0.07% | 1,277 | -41% | 0% | $8,335 |
| CITIGROUP INC | 0.04% | 705 | -11% | 0% | $4,646 |
| Tower Research Capital LLC (TRC) | 0.03% | 534 | -64% | 0% | $3,485 |
| FMR LLC | 0.02% | 406 | -77% | 0% | $2,676 |
| Signature Resources Capital Management, LLC | 0.02% | 400 | 0% | 0% | $2,610 |
| EverSource Wealth Advisors, LLC | 0.02% | 345 | -3.6% | 0% | $2,251 |
| JONES FINANCIAL COMPANIES LLLP | 0.01% | 210 | +2000% | 0% | $1,359 |
| Fortitude Family Office, LLC | 0.01% | 96 | 0% | $627 | |
| SBI Securities Co., Ltd. | 0% | 80 | -5.9% | 0% | $522 |
| JPMORGAN CHASE & CO | 0% | 27 | -86% | 0% | $178 |
| COMERICA BANK | 0% | 23 | 0% | 0% | $150 |
| OSAIC HOLDINGS, INC. | 0% | 22 | 0% | $143 | |
| Wilmington Savings Fund Society, FSB | 0% | 20 | 0% | $131 | |
| BANK OF AMERICA CORP /DE/ | 0% | 18 | -100% | 0% | $117 |
| BNP PARIBAS FINANCIAL MARKETS | 0% | 16 | 0% | 0% | $104 |
| IFP Advisors, Inc | 0% | 2 | -67% | 0% | $13 |