| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 10% | $274,137,801 | 30,871,374 | The Vanguard Group | 28 Nov 2025 | |||
| WELLINGTON MANAGEMENT GROUP LLP | 9.5% | $214,034,195 | 28,461,994 | Wellington Management Group LLP | 31 Dec 2024 | |||
| BlackRock, Inc. | 7.4% | -21% | $171,198,846 | -$38,641,761 | 22,765,804 | -18% | BlackRock, Inc. | 31 Mar 2025 |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 5.2% | +6% | $125,877,122 | +$9,421,352 | 15,974,254 | +8.1% | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 30 Sep 2025 |
| Avoro Capital Advisors LLC | 4.9% | -26% | $118,397,000 | -$43,143,000 | 15,025,000 | -27% | Avoro Capital Advisors LLC | 30 Sep 2025 |
| Redmile Group, LLC | 4.6% | $106,667,402 | 14,184,495 | Redmile Group, LLC | 31 Dec 2024 | |||
| PERCEPTIVE ADVISORS LLC | 2.4% | -66% | $43,290,927 | -$82,061,910 | 7,412,830 | -65% | Perceptive Advisors LLC | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| VANGUARD GROUP INC | 9.6% | 29,534,029 | +0.43% | 0% | $232,728,149 |
| WELLINGTON MANAGEMENT GROUP LLP | 9.3% | 28,628,829 | -1.7% | 0.04% | $225,595,173 |
| BlackRock, Inc. | 8.4% | 25,848,965 | -6.1% | 0% | $203,689,844 |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 5.1% | 15,749,240 | +7.6% | 0.32% | $124,104,011 |
| Avoro Capital Advisors LLC | 4.9% | 15,025,000 | -17% | 1.5% | $118,397,000 |
| MILLENNIUM MANAGEMENT LLC | 3.8% | 11,809,796 | +59% | 0.07% | $93,061,192 |
| STATE STREET CORP | 3.7% | 11,562,939 | -0.04% | 0% | $91,115,959 |
| Vestal Point Capital, LP | 3.2% | 9,750,000 | -18% | 3.5% | $76,830,000 |
| CITADEL ADVISORS LLC | 2.7% | 8,250,140 | +38% | 0.05% | $65,011,103 |
| Point72 Asset Management, L.P. | 2.3% | 7,156,557 | +118% | 0.12% | $56,393,679 |
| BANK OF AMERICA CORP /DE/ | 2.3% | 7,109,070 | +3.8% | 0% | $56,019,468 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.3% | 7,099,093 | +5.9% | 0% | $55,950,545 |
| Pictet Asset Management Holding SA | 2.2% | 6,788,164 | +74% | 0.05% | $53,619,642 |
| PERCEPTIVE ADVISORS LLC | 2.1% | 6,370,851 | -14% | 1.5% | $50,202,306 |
| Palo Alto Investors LP | 1.7% | 5,367,798 | -4.3% | 7.8% | $42,298,248 |
| Soleus Capital Management, L.P. | 1.5% | 4,690,000 | 2% | $36,957,200 | |
| Nuveen, LLC | 1.5% | 4,622,397 | +27% | 0.01% | $36,424,489 |
| MACQUARIE GROUP LTD | 1.5% | 4,560,810 | -41% | 0.04% | $35,939,000 |
| D. E. Shaw & Co., Inc. | 1.3% | 3,868,210 | -39% | 0.02% | $30,481,495 |
| GOLDMAN SACHS GROUP INC | 1.2% | 3,784,218 | -13% | 0% | $29,819,639 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1.2% | 3,708,738 | -0.48% | 0.01% | $29,224,855 |
| RICE HALL JAMES & ASSOCIATES, LLC | 1.1% | 3,434,717 | +24% | 1.5% | $27,065,570 |
| NORTHERN TRUST CORP | 1.1% | 3,337,375 | +8% | 0% | $26,298,515 |
| MORGAN STANLEY | 1% | 3,198,670 | -25% | 0% | $25,205,520 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.89% | 2,752,098 | +8% | 0% | $21,686,532 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 152,305 | $2,170,779 | -$22,496,708 | $14.24 | 6 |
| 2025 Q3 | 312,156,065 | $2,459,923,997 | -$41,517,408 | $7.88 | 282 |
| 2025 Q2 | 319,344,550 | $1,830,820,509 | +$26,198,234 | $5.73 | 269 |
| 2025 Q1 | 309,423,212 | $2,526,512,925 | +$26,438,324 | $8.16 | 281 |
| 2024 Q4 | 305,140,281 | $2,874,465,217 | -$56,740,355 | $9.42 | 286 |
| 2024 Q3 | 309,836,000 | $3,309,105,094 | -$75,379,629 | $10.68 | 289 |
| 2024 Q2 | 315,168,068 | $3,126,533,611 | -$75,738,128 | $9.92 | 256 |
| 2024 Q1 | 321,847,405 | $3,791,483,281 | +$26,707,749 | $11.78 | 253 |
| 2023 Q4 | 318,908,725 | $4,524,863,003 | +$261,463,996 | $14.19 | 226 |
| 2023 Q3 | 298,862,861 | $3,633,462,965 | -$93,168,939 | $12.16 | 228 |
| 2023 Q2 | 307,102,100 | $3,857,183,589 | +$125,609,285 | $12.56 | 212 |
| 2023 Q1 | 297,533,564 | $3,299,196,032 | +$66,985,676 | $11.09 | 222 |
| 2022 Q4 | 292,444,452 | $3,570,548,028 | +$6,804,421 | $12.21 | 225 |
| 2022 Q3 | 292,887,704 | $3,053,948,950 | -$136,712,515 | $10.44 | 218 |
| 2022 Q2 | 305,130,656 | $3,277,204,978 | +$27,959,920 | $10.74 | 197 |
| 2022 Q1 | 303,248,438 | $2,872,272,289 | +$16,415,995 | $9.47 | 199 |
| 2021 Q4 | 301,421,729 | $3,479,958,222 | +$96,361,873 | $11.55 | 215 |
| 2021 Q3 | 292,731,132 | $2,798,448,068 | +$153,922,424 | $9.55 | 223 |
| 2021 Q2 | 276,914,599 | $2,669,802,857 | +$6,810,492 | $9.64 | 222 |
| 2021 Q1 | 275,685,202 | $2,723,386,669 | -$230,544,914 | $9.88 | 241 |
| 2020 Q4 | 279,155,505 | $6,445,326,162 | +$41,955,777 | $23.09 | 267 |
| 2020 Q3 | 277,950,423 | $3,923,978,054 | -$60,291,396 | $14.12 | 241 |
| 2020 Q2 | 281,585,235 | $4,247,304,450 | +$7,015,222 | $15.08 | 217 |
| 2020 Q1 | 283,489,123 | $2,618,877,274 | +$72,473,358 | $9.24 | 194 |
| 2019 Q4 | 275,145,261 | $2,679,735,821 | +$17,027,225 | $9.74 | 211 |
| 2019 Q3 | 273,274,367 | $2,191,232,241 | +$7,544,973 | $8.02 | 195 |
| 2019 Q2 | 268,775,703 | $3,353,010,219 | +$246,345,026 | $12.48 | 202 |
| 2019 Q1 | 250,783,992 | $3,410,473,734 | +$284,627,731 | $13.60 | 198 |
| 2018 Q4 | 231,135,366 | $2,206,742,744 | +$14,137,230 | $9.58 | 182 |
| 2018 Q3 | 228,274,496 | $2,760,074,376 | -$4,704,604 | $12.09 | 198 |
| 2018 Q2 | 226,320,420 | $3,535,050,017 | +$30,838,151 | $15.62 | 196 |
| 2018 Q1 | 224,632,187 | $3,376,722,825 | +$286,532,653 | $15.04 | 198 |
| 2017 Q4 | 205,784,956 | $2,961,554,572 | +$69,146,321 | $14.39 | 181 |
| 2017 Q3 | 198,393,444 | $2,990,825,396 | +$373,880,068 | $15.08 | 183 |
| 2017 Q2 | 174,164,391 | $1,753,807,994 | +$127,263,729 | $10.07 | 138 |
| 2017 Q1 | 168,794,799 | $1,203,523,835 | +$168,107,989 | $7.13 | 128 |
| 2016 Q4 | 156,858,667 | $779,548,508 | +$23,503,784 | $4.97 | 130 |
| 2016 Q3 | 148,308,742 | $1,096,923,417 | +$112,419,698 | $7.40 | 134 |
| 2016 Q2 | 136,917,771 | $747,537,873 | -$24,940,455 | $5.46 | 124 |
| 2016 Q1 | 139,111,687 | $1,175,012,113 | +$7,378,238 | $8.45 | 126 |
| 2015 Q4 | 138,735,633 | $1,345,655,641 | +$33,592,548 | $9.70 | 136 |
| 2015 Q3 | 127,754,259 | $1,760,477,682 | +$206,267,066 | $13.99 | 144 |
| 2015 Q2 | 112,532,503 | $1,592,136,319 | +$450,570,258 | $14.15 | 137 |
| 2015 Q1 | 82,024,911 | $890,563,041 | +$47,434,297 | $10.88 | 122 |
| 2014 Q4 | 79,806,156 | $663,900,201 | +$233,293,757 | $8.32 | 109 |
| 2014 Q3 | 47,042,933 | $279,906,000 | +$43,116,058 | $5.95 | 94 |
| 2014 Q2 | 40,677,308 | $135,850,107 | +$27,231,794 | $3.34 | 60 |
| 2014 Q1 | 34,301,232 | $71,016,802 | -$323,725 | $2.07 | 67 |