| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Medicxi IV LP | 16.9% | $19,446,240 | 22,352,000 | Medicxi IV GP Limited | 27 Dec 2024 | |||
| Deep Track Capital, LP | 9.87% | $12,280,920 | 14,116,000 | Deep Track Capital, LP | 23 Dec 2024 | |||
| Redmile Group, LLC | 9.9% | $12,121,231 | 13,932,449 | Redmile Group, LLC | 31 Dec 2024 | |||
| TCG Crossover GP II, LLC | 9.99% | $11,478,006 | 13,193,110 | TCG Crossover GP II, LLC | 27 Dec 2024 | |||
| Foresite Capital Fund VI LP | 9.3% | $10,875,000 | 12,500,000 | Foresite Capital Fund VI, L.P. | 23 Dec 2024 | |||
| RTW INVESTMENTS, LP | 8.9% | $10,234,680 | 11,764,000 | RTW Investments, LP | 31 Mar 2025 | |||
| VANGUARD GROUP INC | 6.27% | +2% | $7,202,554 | +$4,651,367 | 8,278,798 | +1.8% | The Vanguard Group | 31 Mar 2025 |
| PERCEPTIVE ADVISORS LLC | 4.5% | $5,115,600 | 5,880,000 | Perceptive Advisors LLC | 31 Dec 2024 | |||
| BlackRock, Inc. | 1.7% | $2,006,761 | 2,306,622 | BlackRock, Inc. | 31 Mar 2025 | |||
| COLUMN GROUP II, LP | 4.9% | $1,395,126 | 1,603,593 | Peter Svennilson | 23 Dec 2024 | |||
| ORBIMED ADVISORS LLC | 6.6% | -33% | $28,023,878 | -$310,734,477 | 1,086,618 | -91.7% | ORBIMED ADVISORS LLC | 30 Sep 2025 |
| FMR LLC | 0.4% | $418,041 | 480,507 | FMR LLC | 31 Jan 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 2,972,512 | $76,661,084 | +$42,075,407 | $25.79 | 3 |
| 2025 Q2 | 1,341,050 | $10,728,400 | -$158,903,455 | $8 | 2 |
| 2025 Q1 | 131,135,934 | $159,984,594 | +$4,424,695 | $1.22 | 89 |
| 2024 Q4 | 126,888,838 | $199,480,129 | +$130,912,564 | $1.58 | 89 |
| 2024 Q3 | 29,799,656 | $59,894,847 | -$5,399,235 | $2.01 | 92 |
| 2024 Q2 | 31,808,667 | $97,015,342 | -$20,514,565 | $3.05 | 100 |
| 2024 Q1 | 31,957,297 | $286,976,309 | -$135,887,644 | $8.98 | 120 |
| 2023 Q4 | 34,982,104 | $869,312,485 | +$6,735,986 | $24.85 | 108 |
| 2023 Q3 | 34,763,427 | $577,769,050 | +$11,319,522 | $16.62 | 96 |
| 2023 Q2 | 34,050,266 | $636,743,238 | +$14,411,769 | $18.7 | 97 |
| 2023 Q1 | 33,297,098 | $610,504,496 | +$19,762,513 | $18.35 | 104 |
| 2022 Q4 | 32,051,948 | $634,583,743 | +$67,138,151 | $19.8 | 92 |
| 2022 Q3 | 29,977,976 | $705,685,698 | -$6,718,488 | $24.06 | 96 |
| 2022 Q2 | 29,739,176 | $542,744,027 | +$30,137,398 | $18.25 | 83 |
| 2022 Q1 | 28,022,792 | $616,047,645 | -$11,376,493 | $21.99 | 82 |
| 2021 Q4 | 26,299,986 | $965,984,248 | +$58,612,650 | $36.73 | 96 |
| 2021 Q3 | 24,839,747 | $731,027,543 | +$65,328,555 | $31.05 | 104 |
| 2021 Q2 | 26,596,757 | $845,609,249 | +$179,542,242 | $31.79 | 107 |
| 2021 Q1 | 20,992,943 | $466,036,000 | +$14,749,147 | $22.2 | 77 |
| 2020 Q4 | 20,445,788 | $403,803,000 | +$1,193,976 | $19.75 | 80 |
| 2020 Q3 | 16,829,467 | $541,869,734 | +$65,277,706 | $32.2 | 66 |
| 2020 Q2 | 14,821,430 | $430,109,022 | +$93,891,523 | $29.02 | 52 |
| 2020 Q1 | 11,682,494 | $247,909,000 | +$53,863,363 | $21.27 | 37 |
| 2019 Q4 | 2,361,079 | $64,437,000 | +$64,437,000 | $27.61 | 25 |