| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 15% | +39% | $198,938,502 | +$61,477,681 | 16,468,419 | +45% | FMR LLC | 31 Dec 2025 |
| PERCEPTIVE ADVISORS LLC | 8.2% | -6.7% | $121,662,640 | +$14,650,251 | 8,952,365 | +14% | Perceptive Advisors LLC | 30 Sep 2025 |
| BlackRock, Inc. | 7.1% | +32% | $94,027,246 | +$34,623,342 | 7,783,648 | +58% | BlackRock, Inc. | 31 Dec 2025 |
| TCG Crossover GP II, LLC | 5.7% | $74,863,306 | 6,243,812 | TCG Crossover GP II, LLC | 31 Dec 2025 | |||
| VANGUARD GROUP INC | 5.3% | +6.8% | $70,123,337 | +$6,416,437 | 5,804,912 | +10% | The Vanguard Group | 31 Dec 2025 |
| Commodore Capital LP | 5.1% | $89,213,500 | 5,650,000 | Commodore Capital LP | 10 Nov 2025 | |||
| Point72 Asset Management, L.P. | 2.6% | -54% | $38,074,233 | -$26,039,432 | 2,801,636 | -41% | Point72 Asset Management, L.P. | 30 Sep 2025 |
| Adage Capital Management, L.P. | 2.5% | -64% | $33,296,889 | -$48,436,878 | 2,777,055 | -59% | Adage Capital Management, L.P. | 31 Dec 2025 |
| Panacea Innovation Ltd | 2.6% | $11,792,000 | 2,200,000 | Panacea Venture Healthcare Fund II, L.P. | 31 Dec 2024 |
As of 31 Dec 2025, 178 institutional investors reported holding 112,308,316 shares of Amylyx Pharmaceuticals, Inc. - Common Stock, $0.0001 par value per share (AMLX). This represents 103% of the company’s total 109,540,561 outstanding shares.
The largest institutional shareholders of Amylyx Pharmaceuticals, Inc. - Common Stock, $0.0001 par value per share (AMLX) together control 85% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 15% | 16,518,419 | +45% | 0.01% | $199,542,502 |
| BlackRock, Inc. | 8.3% | 9,054,431 | +27% | 0% | $109,377,525 |
| PERCEPTIVE ADVISORS LLC | 7.6% | 8,284,882 | -7.5% | 1.8% | $100,081,375 |
| TCG Crossover Management, LLC | 5.7% | 6,243,812 | 0% | 2.5% | $75,425,249 |
| VANGUARD GROUP INC | 5.3% | 5,804,912 | +10% | 0% | $70,123,336 |
| Commodore Capital LP | 5.2% | 5,650,000 | +39% | 4.5% | $68,252,000 |
| Saturn V Capital Management LP | 4.1% | 4,496,487 | -2.4% | 10% | $54,317,563 |
| JANUS HENDERSON GROUP PLC | 4.1% | 4,465,872 | +76% | 0.02% | $53,992,392 |
| First Light Asset Management, LLC | 3.1% | 3,355,539 | -0.01% | 3.1% | $40,534,911 |
| Driehaus Capital Management LLC | 2.8% | 3,109,503 | +28% | 0.26% | $37,562,796 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2.5% | 2,777,055 | -59% | 0.05% | $33,546,824 |
| GOLDMAN SACHS GROUP INC | 2.4% | 2,613,221 | +30% | 0% | $31,567,709 |
| MORGAN STANLEY | 2.2% | 2,359,824 | +21% | 0% | $28,506,673 |
| GEODE CAPITAL MANAGEMENT, LLC | 2% | 2,165,534 | +20% | 0% | $26,163,536 |
| Almitas Capital LLC | 1.9% | 2,122,597 | 0% | 5.6% | $25,640,972 |
| STATE STREET CORP | 1.9% | 2,069,884 | +28% | 0% | $25,004,199 |
| GREAT POINT PARTNERS LLC | 1.6% | 1,750,000 | +2.9% | 6.9% | $21,140,000 |
| 683 Capital Management, LLC | 1.5% | 1,650,000 | -6.2% | 1.7% | $19,932,000 |
| EVENTIDE ASSET MANAGEMENT, LLC | 1.4% | 1,513,148 | +0.04% | 0.29% | $18,278,773 |
| BANK OF AMERICA CORP /DE/ | 1.2% | 1,336,010 | +211% | 0% | $16,139,001 |
| DEUTSCHE BANK AG\ | 1.2% | 1,333,236 | -2.4% | 0.01% | $16,105,491 |
| FRANKLIN RESOURCES INC | 1.1% | 1,200,096 | 0% | $14,497,160 | |
| Connor, Clark & Lunn Investment Management Ltd. | 0.92% | 1,004,021 | -9.3% | 0.03% | $12,128,574 |
| Logos Global Management LP | 0.87% | 950,000 | -34% | 0.76% | $11,476,000 |
| NORTHERN TRUST CORP | 0.86% | 937,764 | +14% | 0% | $11,328,189 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 112,308,316 | $1,356,738,139 | +$21,421,387 | $12.08 | 178 |
| 2025 Q3 | 109,720,694 | $1,491,122,082 | +$396,029,872 | $13.59 | 168 |
| 2025 Q2 | 81,690,006 | $523,632,250 | +$57,316,535 | $6.41 | 131 |
| 2025 Q1 | 73,877,500 | $261,528,744 | +$85,099,354 | $3.54 | 134 |
| 2024 Q4 | 49,784,011 | $188,180,501 | +$19,458,443 | $3.78 | 120 |
| 2024 Q3 | 43,406,257 | $140,608,833 | +$5,128,506 | $3.24 | 107 |
| 2024 Q2 | 43,632,024 | $82,904,189 | -$16,885,307 | $1.90 | 115 |
| 2024 Q1 | 49,485,594 | $140,539,742 | -$234,955,037 | $2.84 | 138 |
| 2023 Q4 | 60,281,638 | $887,348,868 | -$11,902,243 | $14.72 | 177 |
| 2023 Q3 | 58,927,724 | $1,078,966,869 | +$84,065,478 | $18.31 | 168 |
| 2023 Q2 | 54,545,075 | $1,176,653,052 | +$56,163,167 | $21.57 | 153 |
| 2023 Q1 | 51,372,917 | $1,507,231,117 | +$73,671,274 | $29.34 | 145 |
| 2022 Q4 | 48,572,530 | $1,794,757,212 | +$422,522,242 | $36.95 | 131 |
| 2022 Q3 | 36,858,311 | $1,037,561,470 | +$315,174,073 | $28.15 | 90 |
| 2022 Q2 | 26,621,859 | $512,910,346 | +$65,322,870 | $19.26 | 74 |
| 2022 Q1 | 23,420,880 | $299,935,403 | +$299,912,422 | $12.85 | 72 |