| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Fairmount Funds Management LLC | 10% | $136,033,480 | 8,106,882 | Peter Evan Harwin | 15 Oct 2025 | |||
| BlackRock, Inc. | 6.6% | $59,323,024 | 3,962,635 | BlackRock, Inc. | 30 Jun 2025 | |||
| RTW INVESTMENTS, LP | 6.2% | $54,402,380 | 3,621,996 | RTW Investments, LP | 31 Dec 2024 | |||
| TANG CAPITAL MANAGEMENT LLC | 5.3% | $48,064,000 | 3,200,000 | TANG CAPITAL MANAGEMENT, LLC | 24 Apr 2025 | |||
| VANGUARD GROUP INC | 5.1% | $45,907,406 | 3,066,586 | The Vanguard Group | 30 Jun 2025 | |||
| Venrock Healthcare Capital Partners III, L.P. | 4.6% | $40,335,429 | 2,685,448 | Venrock Healthcare Capital Partners III, L.P. | 31 Dec 2024 | |||
| PERCEPTIVE ADVISORS LLC | 4.4% | -56% | $38,672,339 | -$185,961,697 | 2,574,723 | -80% | Perceptive Advisors LLC | 31 Dec 2024 |
As of 30 Sep 2025, 135 institutional investors reported holding 64,298,633 shares of Spyre Therapeutics, Inc. - Common Stock, $0.0001 par value (SYRE). This represents 79% of the company’s total 81,149,970 outstanding shares.
The largest institutional shareholders of Spyre Therapeutics, Inc. - Common Stock, $0.0001 par value (SYRE) together control 67% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 11% | 9,060,144 | +0.08% | 0.01% | $151,848,013 |
| Fairmount Funds Management LLC | 5% | 4,018,101 | 0% | 6.1% | $67,343,373 |
| BlackRock, Inc. | 4.9% | 3,982,744 | -0.61% | 0% | $66,750,788 |
| RTW INVESTMENTS, LP | 4.5% | 3,621,996 | 0% | 0.75% | $60,704,653 |
| TANG CAPITAL MANAGEMENT LLC | 3.9% | 3,200,000 | 0% | 2.1% | $53,632,000 |
| VANGUARD GROUP INC | 3.8% | 3,050,730 | -0.52% | 0% | $51,130,235 |
| VR ADVISER, LLC | 3.3% | 2,685,448 | 0% | 2.5% | $45,008,108 |
| BRAIDWELL LP | 3.2% | 2,578,404 | 0% | 1.3% | $43,214,051 |
| Capital International Investors | 2.9% | 2,392,541 | 0% | 0.01% | $40,098,987 |
| Driehaus Capital Management LLC | 2.5% | 2,060,375 | -1.2% | 0.25% | $34,531,885 |
| Commodore Capital LP | 2.4% | 1,988,084 | 0% | 1.6% | $33,320,288 |
| STATE STREET CORP | 2.2% | 1,785,206 | +12% | 0% | $29,920,053 |
| WELLINGTON MANAGEMENT GROUP LLP | 2% | 1,640,312 | +8.4% | 0% | $27,491,629 |
| Paradigm Biocapital Advisors LP | 1.8% | 1,467,266 | -22% | 0.73% | $24,591,378 |
| Affinity Asset Advisors, LLC | 1.7% | 1,419,299 | +134% | 2.2% | $23,787,451 |
| Jefferies Financial Group Inc. | 1.7% | 1,388,854 | 0% | 0.21% | $23,277,193 |
| PERCEPTIVE ADVISORS LLC | 1.5% | 1,229,445 | -20% | 0.6% | $20,605,498 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.5% | 1,225,153 | -0.17% | 0% | $20,536,009 |
| TCG Crossover Management, LLC | 1.4% | 1,100,582 | 0.91% | $18,445,754 | |
| Pictet Asset Management Holding SA | 1.3% | 1,036,218 | -4% | 0.02% | $17,367,014 |
| BAKER BROS. ADVISORS LP | 1.2% | 1,000,000 | +60% | 0.12% | $16,760,000 |
| FRANKLIN RESOURCES INC | 0.98% | 795,275 | 0% | 0% | $13,328,809 |
| Polar Capital Holdings Plc | 0.97% | 788,788 | +5.9% | 0.06% | $13,220,087 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0.76% | 620,620 | -33% | 0% | $10,402,000 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0.76% | 613,665 | 0% | 0.16% | $10,285,025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 46,584 | $1,526,375 | +$768,997 | $32.76 | 5 |
| 2025 Q3 | 64,298,633 | $1,077,601,498 | +$12,200,647 | $16.76 | 135 |
| 2025 Q2 | 63,624,754 | $952,552,077 | +$19,485,332 | $14.97 | 128 |
| 2025 Q1 | 62,108,053 | $1,004,204,799 | +$22,237,875 | $16.14 | 128 |
| 2024 Q4 | 59,883,954 | $1,394,038,124 | +$171,655,898 | $23.28 | 129 |
| 2024 Q3 | 51,375,323 | $1,511,815,633 | +$36,820,905 | $29.41 | 118 |
| 2024 Q2 | 50,382,939 | $1,184,222,119 | +$421,575,660 | $23.51 | 106 |
| 2024 Q1 | 31,640,426 | $1,196,964,043 | +$172,560,163 | $37.93 | 101 |
| 2023 Q4 | 28,010,905 | $600,997,673 | +$524,495,293 | $21.52 | 54 |
| 2023 Q3 | 3,257,983 | $39,909,852 | +$39,909,852 | $12.25 | 27 |