Spyre Therapeutics, Inc. - Common Stock, $0.0001 par value (SYRE)

Historical Holders from Q3 2023 to Q3 2025

Symbol
SYRE on Nasdaq
Type / Class
Equity / Common Stock, $0.0001 par value
Shares outstanding
81,149,970
All holders as of 30 Sep 2025
Q3 2025
Total 13F shares, excl. options
64,298,633
Holdings value
$1,077,601,498
% of all portfolios
0%
Number of holders
135
Number of buys
63
Number of sells
-57
Average buys %
+0%
Average sells %
-0%
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Spyre Therapeutics, Inc. - Common Stock, $0.0001 par value (SYRE)

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
Fairmount Funds Management LLC 9.99% $136,033,480 8,106,882 Peter Evan Harwin 15 Oct 2025
BlackRock, Inc. 6.6% $59,323,024 3,962,635 BlackRock, Inc. 30 Jun 2025
RTW INVESTMENTS, LP 6.2% $54,402,380 3,621,996 RTW Investments, LP 31 Dec 2024
TANG CAPITAL MANAGEMENT LLC 5.3% $48,064,000 3,200,000 TANG CAPITAL MANAGEMENT, LLC 24 Apr 2025
VANGUARD GROUP INC 5.08% $45,907,406 3,066,586 The Vanguard Group 30 Jun 2025
Venrock Healthcare Capital Partners III, L.P. 4.6% $40,335,429 2,685,448 Venrock Healthcare Capital Partners III, L.P. 31 Dec 2024
PERCEPTIVE ADVISORS LLC 4.4% -56% $38,672,339 -$185,961,697 2,574,723 -79.6% Perceptive Advisors LLC 31 Dec 2024

Institutional Holders of Spyre Therapeutics, Inc. - Common Stock, $0.0001 par value (SYRE)

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price Investors
2025 Q3 64,298,633 $1,077,601,498 +$12,200,647 $16.76 135
2025 Q2 63,624,754 $952,552,077 +$19,485,332 $14.97 128
2025 Q1 62,108,053 $1,004,204,799 +$22,237,875 $16.14 128
2024 Q4 59,883,954 $1,394,038,124 +$171,655,898 $23.28 129
2024 Q3 51,375,323 $1,511,815,633 +$36,820,905 $29.41 118
2024 Q2 50,382,939 $1,184,222,119 +$421,575,660 $23.51 106
2024 Q1 31,640,426 $1,196,964,043 +$172,560,163 $37.93 101
2023 Q4 28,010,905 $600,997,673 +$524,495,293 $21.52 54
2023 Q3 3,257,983 $39,909,852 +$39,909,852 $12.25 27