| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 10% | $47,123,411 | 6,770,605 | Perceptive Advisors LLC | 11 Nov 2025 | |||
| Venrock Healthcare Capital Partners III, L.P. | 9.9% | $20,185,656 | 5,046,414 | Venrock Healthcare Capital Partners III, L.P. | 31 Dec 2024 | |||
| Kynam Capital Management, LP | 9.8% | $19,976,360 | 4,994,090 | Kynam Capital Management, LP | 31 Dec 2024 | |||
| Deep Track Capital, LP | 6.7% | +58% | $30,048,631 | +$14,462,734 | 4,317,332 | +93% | Deep Track Capital, LP | 11 Nov 2025 |
| Fonds de solidarite des travailleurs et des travailleuses du Quebec | 4.5% | $8,119,004 | 2,029,751 | Fonds de solidarite des travailleurs et des travailleuses du Quebec | 30 Sep 2024 | |||
| Adage Capital Management, L.P. | 3% | $6,115,072 | 1,528,768 | Adage Capital Management, L.P. | 31 Dec 2024 | |||
| BIOTECHNOLOGY VALUE FUND L P | 1.8% | -68% | $3,781,608 | -$8,424,148 | 945,402 | -69% | BVF PARTNERS L P/IL | 27 Jan 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FCPM III SERVICES B.V. | 15% | 9,632,561 | 0% | 13% | $65,790,391 |
| VR ADVISER, LLC | 7.8% | 5,046,414 | 0% | 1.9% | $34,467,008 |
| Kynam Capital Management, LP | 7.7% | 4,994,090 | 0% | 2.5% | $34,109,635 |
| Blue Owl Capital Holdings LP | 5.1% | 3,278,106 | -12% | 7% | $22,389,464 |
| Cormorant Asset Management, LP | 3.6% | 2,323,595 | 0% | 1.1% | $15,870,154 |
| BRAIDWELL LP | 3.5% | 2,266,319 | 0.46% | $15,478,959 | |
| Deep Track Capital, LP | 3.5% | 2,239,353 | -51% | 0.43% | $15,294,781 |
| PERCEPTIVE ADVISORS LLC | 3.2% | 2,097,236 | 0.42% | $14,324,122 | |
| Point72 Asset Management, L.P. | 1.9% | 1,208,399 | +0.01% | 0.02% | $8,253,366 |
| Frazier Life Sciences Management, L.P. | 1.8% | 1,157,380 | 0.24% | $7,904,905 | |
| FRANKLIN RESOURCES INC | 1.6% | 1,038,000 | 0% | 0% | $7,089,540 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.5% | 1,000,000 | 0% | 0.01% | $6,830,000 |
| SR One Capital Management, LP | 1.2% | 747,750 | 0% | 0.74% | $5,107,133 |
| BANK OF AMERICA CORP /DE/ | 1% | 647,192 | -68% | 0% | $4,420,321 |
| MPM BIOIMPACT LLC | 0.82% | 530,299 | 0.59% | $3,621,942 | |
| Omega Fund Management, LLC | 0.82% | 526,357 | 0% | 1.6% | $3,595,018 |
| SPHERA FUNDS MANAGEMENT LTD. | 0.78% | 504,409 | 0% | 0.82% | $3,445,113 |
| MORGAN STANLEY | 0.67% | 435,291 | +23% | 0% | $2,973,037 |
| Vestal Point Capital, LP | 0.57% | 370,000 | 0% | 0.11% | $2,527,100 |
| MARSHALL WACE, LLP | 0.53% | 343,928 | 0% | 0% | $2,349,028 |
| GOLDMAN SACHS GROUP INC | 0.23% | 147,602 | -84% | 0% | $1,008,122 |
| Affinity Asset Advisors, LLC | 0.12% | 77,000 | 0% | 0.05% | $525,910 |
| CITADEL ADVISORS LLC | 0.09% | 58,370 | +153% | 0% | $398,667 |
| NORTHERN TRUST CORP | 0.05% | 30,295 | -8.3% | 0% | $206,915 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.04% | 29,018 | 0% | 0% | $198,192 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 40,868,497 | $279,131,773 | +$5,402,489 | 683% | 38 |
| 2025 Q2 | 40,420,485 | $147,130,372 | -$1,920,470 | 364% | 37 |
| 2025 Q1 | 40,941,351 | $183,416,794 | -$6,334,706 | 448% | 31 |
| 2024 Q4 | 41,304,528 | $274,675,480 | +$47,869,542 | 665% | 34 |
| 2024 Q3 | 34,293,391 | $227,693,885 | +$6,723,051 | 660% | 30 |
| 2024 Q2 | 32,608,601 | $307,109,469 | -$7,912,013 | 943% | 30 |
| 2024 Q1 | 31,657,538 | $536,055,932 | +$295,887,521 | 1,695% | 31 |
| 2023 Q4 | 14,187,864 | $130,941,207 | +$50,843,719 | 923% | 11 |